Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)
Website using assistance : Leihong Wu (11019004@zju.edu.cn)
Coronary Heart Disease Research Platform
Description: CD4 molecule
Entrez Gene ID: 920
SwissProt Acc Number: P01730
RefSeq: NM_000616
It was supported literatures to be a novel CHD related gene:..The data suggest that CD4+T lymphocytes infiltrating cardiac tissue may play a pathogenic role in dilated cardiomyopathy..
From PMID: 16418801, in Journal J Clin Immunol. , 2006There were 59 potential papers with CD4 and CHD.
| PMID | Title | Journals | Details |
|---|---|---|---|
| 23984974 | Plasma Monocyte Chemoattractant Protein-1 and Tumor Necrosis Factor-alpha Levels Predict the Presence of Coronary Artery Calcium in HIV-Infected Individuals Independent of Traditional Cardiovascular Risk Factors. | AIDS research and human retroviruses | More Details |
| 23945252 | Progression of carotid intima-media thickness and coronary artery calcium over 6 years in an HIV-infected cohort. | Journal of acquired immune deficiency syndromes (1999) | More Details |
| 24045547 | Small-dense LDL cholesterol/large-buoyant LDL cholesterol ratio as an excellent marker for indicating lipodystrophy in HIV-infected patients. | American journal of clinical pathology | More Details |
| 24275676 | Initiation of antiretroviral therapy at high CD4 cell counts: does it reduce the risk of cardiovascular disease? | Current opinion in HIV and AIDS | More Details |
| 23324657 | Increased coronary atherosclerotic plaque vulnerability by coronary computed tomography angiography in HIV-infected men. | "AIDS (London, England)" | More Details |
| 23688675 | T-helper type 1 bias in healthy people is associated with cytomegalovirus serology and atherosclerosis: the multi-ethnic study of atherosclerosis. | Journal of the American Heart Association | More Details |
| 23322918 | The biological effects of individual-level PM(2.5) exposure on systemic immunity and inflammatory response in traffic policemen. | Occupational and environmental medicine | More Details |
| 23842128 | Associations between immune depression and cardiovascular events in HIV infection. | "AIDS (London, England)" | More Details |
| 23349927 | "Psychological factors, including alexithymia, in the prediction of cardiovascular risk in HIV infected patients: results of a cohort study." | PloS one | More Details |
| 24265555 | Vitamin D deficiency is associated with development of subclinical coronary artery disease in HIV-infected African American cocaine users with low Framingham-defined cardiovascular risk. | Vascular health and risk management | More Details |
| 22809446 | Which leukocyte subsets predict cardiovascular mortality? From the LUdwigshafen RIsk and Cardiovascular Health (LURIC) Study. | Atherosclerosis | More Details |
| 23146484 | Correlation of immunological markers with graft vasculopathy development in heart transplantation. | Transplantation proceedings | More Details |
| 22481166 | Vitamin D deficiency is associated with the development of subclinical coronary artery disease in African Americans with HIV infection: a preliminary study. | Journal of investigative medicine : the official publication of the American | More Details |
| 22820791 | Arterial inflammation in patients with HIV. | JAMA : the journal of the American Medical Association | More Details |
| 22193234 | Local and systemic cellular immunity in early renal artery atherosclerosis. | Clinical journal of the American Society of Nephrology : CJASN | More Details |
| 22048682 | Contribution of the human immunodeficiency virus/acquired immunodeficiency syndrome epidemic to de novo presentations of heart disease in the Heart of Soweto Study cohort. | European heart journal | More Details |
| 22396788 | Lymphocyte subpopulations in lymph nodes and peripheral blood: a comparison between patients with stable angina and acute coronary syndrome. | PloS one | More Details |
| 23180454 | Impact of immunodepression and moderate alcohol consumption on coronary and other arterial disease events in an 11-year cohort of HIV-infected patients on antiretroviral therapy. | BMJ open | More Details |
| 21251186 | Fatty liver disease is associated with underlying cardiovascular disease in HIV-infected persons(*). | HIV medicine | More Details |
| 21889313 | Chlamydia pneumoniae heat shock protein 60 is associated with apoptotic signaling pathway in human atheromatous plaques of coronary artery disease patients. | Journal of cardiology | More Details |
| 21839249 | Assessment of immunological markers as mediators of graft vasculopathy development in heart transplantation. | Transplantation proceedings | More Details |
| 21712519 | The risk of incident coronary heart disease among veterans with and without HIV and hepatitis C. | Circulation. Cardiovascular quality and outcomes | More Details |
| 21195379 | Clinically significant incidental findings among human immunodeficiency virus-infected men during computed tomography for determination of coronary artery calcium. | The American journal of cardiology | More Details |
| 22055099 | Interleukin-16 deficiency suppresses the development of chronic rejection in murine cardiac transplantation model. | The Journal of heart and lung transplantation : the official publication of the | More Details |
| 21288058 | Cost effectiveness of atazanavir-ritonavir versus lopinavir-ritonavir in treatment-naive human immunodeficiency virus-infected patients in the United States. | Journal of medical economics | More Details |
| 20131226 | Cardiovascular disease in patients with inflammatory rheumatic disease is associated with up-regulation of markers of inflammation in cardiac microvessels and cardiomyocytes. | Arthritis and rheumatism | More Details |
| 20543654 | Initiation of antiretroviral therapy at higher nadir CD4+ T-cell counts is associated with reduced arterial stiffness in HIV-infected individuals. | "AIDS (London, England)" | More Details |
| 20635253 | One year survival of HIV-infected veterans with CD4 < 100 cells/mm3: data from a veteran cohort. | AIDS care | More Details |
| 19996940 | Increased prevalence of subclinical coronary atherosclerosis detected by coronary computed tomography angiography in HIV-infected men. | "AIDS (London, England)" | More Details |
| 21048535 | The indirect alloimmune response causes microvascular endothelial dysfunction-a possible role for alloantibody. | Transplantation | More Details |
| 18427358 | Plasma lipid-dependent and -independent effects of dietary soy protein and social status on atherogenesis in premenopausal monkeys: implications for postmenopausal atherosclerosis burden. | "Menopause (New York, N.Y.)" | More Details |
| 18418233 | Subclinic atherosclerosis and cardiovascular risk factors in HIV-infected children: PERI study. | Coronary artery disease | More Details |
| 19059114 | CXCL12 induction of inducible nitric oxide synthase in human CD8 T cells. | The Journal of heart and lung transplantation : the official publication of the | More Details |
| 18393684 | Human cord blood mononuclear cells decrease cytokines and inflammatory cells in acute myocardial infarction. | Stem cells and development | More Details |
| 18923695 | Dyslipidemia and cardiovascular disease risk factor management in HIV-1-infected subjects treated with HAART in the Spanish VACH cohort. | The open AIDS journal | More Details |
| 17998494 | Cystatin C level as a marker of kidney function in human immunodeficiency virus infection: the FRAM study. | Archives of internal medicine | More Details |
| 17414708 | "Riboflavin-mediated reduction of oxidant injury, rejection, and vasculopathy after cardiac allotransplantation." | Transplantation | More Details |
| 17261328 | Frequency of naturally-occurring regulatory T cells is reduced in patients with ST-segment elevation myocardial infarction. | Thrombosis research | More Details |
| 16983590 | "Infectious agents, inflammation, and growth factors: how do they interact in the progression or stabilization of mild human atherosclerotic lesions?" | Annals of vascular surgery | More Details |
| 17015794 | T-cell immunity to subclinical cytomegalovirus infection reduces cardiac allograft disease. | Circulation | More Details |
| 17015796 | The chemokine and chemokine receptor profile of infiltrating cells in the wall of arteries with cardiac allograft vasculopathy is indicative of a memory T-helper 1 response. | Circulation | More Details |
| 16954132 | Altered status of CD4(+)CD25(+) regulatory T cells in patients with acute coronary syndromes. | European heart journal | More Details |
| 16601227 | T cell recognition and killing of vascular smooth muscle cells in acute coronary syndrome. | Circulation research | More Details |
| 16424368 | Interleukin 12 induces T-cell recruitment into the atherosclerotic plaque. | Circulation research | More Details |
| 16925217 | Initial experience with bariatric surgery in asymptomatic human immunodeficiency virus-infected patients. | Surgery for obesity and related diseases : official journal of the American | More Details |
| 15585311 | Altered trafficking of CD8+ memory T cells after implantation of rapamycin-eluting stents in patients with coronary artery disease. | Immunology letters | More Details |
| 16297172 | The immune responses to human and microbial heat shock proteins in periodontal disease with and without coronary heart disease. | Clinical and experimental immunology | More Details |
| 15093715 | Characterization of two populations of human coronary artery endothelial cells(1). | The Journal of surgical research | More Details |
| 15255036 | "Cardiac, aortic, and pulmonary arteriopathy in HIV-infected children: the Prospective P2C2 HIV Multicenter Study." | Pediatric and developmental pathology : the official journal of the Society for | More Details |
| 15023877 | Progression of atherosclerosis as assessed by carotid intima-media thickness in patients with HIV infection. | Circulation | More Details |
| 12736856 | "[HIV-infection, HAART (highly-active antiretroviral therapy) and hyperlipidemia]." | Deutsche medizinische Wochenschrift (1946) | More Details |
| 12819520 | Cardiovascular disease risk factors in HIV patients--association with antiretroviral therapy. Results from the DAD study. | "AIDS (London, England)" | More Details |
| 12739013 | Coronary artery disease in HIV infected patients. | Intensive care medicine | More Details |
| 12816883 | De novo expression of killer immunoglobulin-like receptors and signaling proteins regulates the cytotoxic function of CD4 T cells in acute coronary syndromes. | Circulation research | More Details |
| 12821825 | Lipid profiles associated with antiretroviral drug choices. | Current opinion in infectious diseases | More Details |
| 12368204 | The role of MIG/CXCL9 in cardiac allograft vasculopathy. | The American journal of pathology | More Details |
| 11863225 | Fatal cytotoxic T-cell proliferation in chronic active Epstein-Barr virus infection in childhood. | American journal of clinical pathology | More Details |
| 11528596 | CD8 T lymphocytes and macrophages infiltrate coronary artery aneurysms in acute Kawasaki disease. | The Journal of infectious diseases | More Details |
| 11504923 | HIV envelope gp120 activates human arterial smooth muscle cells. | Proceedings of the National Academy of Sciences of the United States of America | More Details |
NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.
There were totally 96 unique genes interacted with CD4. Show PPI network
| Gene name | Interaction type | reference PMID | CHD relation |
|---|---|---|---|
| UNC119 | Affinity Capture-Western | 14757743 | No |
| SPG21 | Affinity Capture-Western | 11113139|11113139 | No |
| PIP | Reconstituted Complex | 10820003 | No |
| CCR5 | Affinity Capture-Western | 10816381 | CHD related |
| CXCR4 | Affinity Capture-Western | 10816381|15660419 | CHD related |
| LCK | Affinity Capture-Western | 12007789|11854499|15047060|16888650|11854499,8104794 | No |
| IL16 | Reconstituted Complex | 7910967 | No |
| BTRC | Affinity Capture-Western | 9660940 | No |
| CD81 | Affinity Capture-Western | 7636191 | No |
| CD82 | Affinity Capture-Western | 7636191 | No |
| KCNAB2 | Affinity Capture-Western | 12893943 | No |
| SYK | Affinity Capture-Western | 7539035 | No |
| ZAP70 | Affinity Capture-Western | 7539035 | No |
| UBC | Affinity Capture-Western | 17937819|16497223|20442859|20974815|17686993|22090097 | No |
| EPS15 | Affinity Capture-Western | 16497223 | No |
| nef | FRET | 20179761|8599760 | No |
| vpu | FRET | 20179761|20442859|22090097 | No |
| LRPPRC | Affinity Capture-MS | 15047060 | No |
| EIF3C | Affinity Capture-MS | 15047060 | No |
| TNPO1 | Affinity Capture-MS | 15047060 | No |
| KPNB1 | Affinity Capture-MS | 15047060 | No |
| EIF3B | Affinity Capture-MS | 15047060 | No |
| HSP90AA1 | Affinity Capture-MS | 15047060 | CHD related |
| MME | Affinity Capture-MS | 15047060 | No |
| HSP90AB1 | Affinity Capture-MS | 15047060 | CHD related |
| SSRP1 | Affinity Capture-MS | 15047060 | No |
| ANXA6 | Affinity Capture-MS | 15047060 | No |
| NCL | Affinity Capture-MS | 15047060 | No |
| DDX3X | Affinity Capture-MS | 15047060 | No |
| HSPA8 | Affinity Capture-MS | 15047060 | CHD related |
| DDX5 | Affinity Capture-MS | 15047060 | No |
| FARSB | Affinity Capture-MS | 15047060 | No |
| EIF3D | Affinity Capture-MS | 15047060 | No |
| HSPD1 | Affinity Capture-MS | 15047060 | CHD related |
| ATP5A1 | Affinity Capture-MS | 15047060 | No |
| CD4 | Affinity Capture-MS | 15047060|12444132 | CHD related |
| VIM | Affinity Capture-MS | 15047060 | CHD related |
| TUBB | Affinity Capture-MS | 15047060 | No |
| HNRNPH1 | Affinity Capture-MS | 15047060 | No |
| ENO1 | Affinity Capture-MS | 15047060 | CHD related |
| EIF4A2 | Affinity Capture-MS | 15047060 | No |
| GNAI2 | Affinity Capture-MS | 15047060 | No |
| ANXA1 | Affinity Capture-MS | 15047060 | CHD related |
| HNRNPA1 | Affinity Capture-MS | 15047060 | No |
| ANXA2 | Affinity Capture-MS | 15047060 | No |
| HNRNPD | Affinity Capture-MS | 15047060 | No |
| VDAC2 | Affinity Capture-MS | 15047060 | No |
| HNRNPA2B1 | Affinity Capture-MS | 15047060 | No |
| EIF3I | Affinity Capture-MS | 15047060 | No |
| GAPDH | Affinity Capture-MS | 15047060 | No |
| RPLP0 | Affinity Capture-MS | 15047060 | No |
| RPSA | Affinity Capture-MS | 15047060 | No |
| NPM1 | Affinity Capture-MS | 15047060 | No |
| VDAC1 | Affinity Capture-MS | 15047060 | No |
| VDAC3 | Affinity Capture-MS | 15047060 | No |
| PHB | Affinity Capture-MS | 15047060 | No |
| RPL7 | Affinity Capture-MS | 15047060 | No |
| DHRS2 | Affinity Capture-MS | 15047060 | No |
| EEF1B2 | Affinity Capture-MS | 15047060 | No |
| RPS9 | Affinity Capture-MS | 15047060 | No |
| RPL18 | Affinity Capture-MS | 15047060 | No |
| MYL12A | Affinity Capture-MS | 15047060 | No |
| RPS10 | Affinity Capture-MS | 15047060 | No |
| RPS19 | Affinity Capture-MS | 15047060 | No |
| RPL22 | Affinity Capture-MS | 15047060 | No |
| RPS12 | Affinity Capture-MS | 15047060 | No |
| RPLP1 | Affinity Capture-MS | 15047060 | No |
| STUB1 | Affinity Capture-Western | 20974815 | No |
| NR3C1 | Affinity Capture-Western | 16888650 | CHD related |
| HGS | Affinity Capture-Western | 17686993 | No |
| VCP | Affinity Capture-Western | 22090097 | No |
| CD44 | in vitro | 7539755 | CHD related |
| CD38 | in vitro | 7539755 | CHD related |
| PIK3R1 | in vitro | 8246987 | CHD related |
| CD28 | in vitro | 7539755 | CHD related |
| CTSD | in vitro | 11581410 | No |
| TNFRSF10A | in vivo | 7650480 | No |
| HLA-DQB1 | in vitro | 11535811 | No |
| TFRC | in vivo | 14705953 | No |
| HLA-DPA1 | in vivo | 12899833 | No |
| FCGR3A | in vitro | 11756173 | CHD related |
| IL2RA | in vitro | 7539755 | CHD related |
| CD53 | in vitro | 7539755 | No |
| CD5 | in vitro | 7539755 | No |
| PTPRC | FRET | 1834739 | CHD related |
| LGALS1 | Affinity Capture-Western | 10490978 | No |
| env | Reconstituted Complex | 1605591|2076345|15321703|2461565 | No |
| MAPK14 | Biochemical Activity | 20530479 | CHD related |
| CD2 | in vitro | 7539755 | No |
| DPP4 | in vitro | 7539755 | CHD related |
| CXCL12 | in vitro | 10600606 | CHD related |
| LAT | in vivo | 10562325 | No |
| SELL | in vitro | 7539755 | CHD related |
| PI4KA | in vitro | 8246987 | No |
| HLA-DQA2 | in vitro | 11535811 | No |
| MARCH4 | in vitro | 14722266 | No |
| Status | DrubBank ID | Name | Indication | ATC Code |
|---|---|---|---|---|
| approved | DB00098 | Antithymocyte globulin | For prevention of renal transplant rejection |