How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: CD4

    Description: CD4 molecule

    Entrez Gene ID: 920

    SwissProt Acc Number: P01730

    RefSeq: NM_000616

    It was supported literatures to be a novel CHD related gene:

    ..The data suggest that CD4+T lymphocytes infiltrating cardiac tissue may play a pathogenic role in dilated cardiomyopathy..

    From PMID: 16418801, in Journal J Clin Immunol. , 2006


    There were 59 potential papers with CD4 and CHD.

    23984974 Plasma Monocyte Chemoattractant Protein-1 and Tumor Necrosis Factor-alpha Levels Predict the Presence of Coronary Artery Calcium in HIV-Infected Individuals Independent of Traditional Cardiovascular Risk Factors.AIDS research and human retrovirusesMore Details
    23945252 Progression of carotid intima-media thickness and coronary artery calcium over 6 years in an HIV-infected cohort.Journal of acquired immune deficiency syndromes (1999)More Details
    24045547 Small-dense LDL cholesterol/large-buoyant LDL cholesterol ratio as an excellent marker for indicating lipodystrophy in HIV-infected patients.American journal of clinical pathologyMore Details
    24275676 Initiation of antiretroviral therapy at high CD4 cell counts: does it reduce the risk of cardiovascular disease?Current opinion in HIV and AIDSMore Details
    23324657 Increased coronary atherosclerotic plaque vulnerability by coronary computed tomography angiography in HIV-infected men."AIDS (London, England)"More Details
    23688675 T-helper type 1 bias in healthy people is associated with cytomegalovirus serology and atherosclerosis: the multi-ethnic study of atherosclerosis.Journal of the American Heart AssociationMore Details
    23322918 The biological effects of individual-level PM(2.5) exposure on systemic immunity and inflammatory response in traffic policemen.Occupational and environmental medicineMore Details
    23842128 Associations between immune depression and cardiovascular events in HIV infection."AIDS (London, England)"More Details
    23349927 "Psychological factors, including alexithymia, in the prediction of cardiovascular risk in HIV infected patients: results of a cohort study."PloS oneMore Details
    24265555 Vitamin D deficiency is associated with development of subclinical coronary artery disease in HIV-infected African American cocaine users with low Framingham-defined cardiovascular risk.Vascular health and risk managementMore Details
    22809446 Which leukocyte subsets predict cardiovascular mortality? From the LUdwigshafen RIsk and Cardiovascular Health (LURIC) Study.AtherosclerosisMore Details
    23146484 Correlation of immunological markers with graft vasculopathy development in heart transplantation.Transplantation proceedingsMore Details
    22481166 Vitamin D deficiency is associated with the development of subclinical coronary artery disease in African Americans with HIV infection: a preliminary study.Journal of investigative medicine : the official publication of the AmericanMore Details
    22820791 Arterial inflammation in patients with HIV.JAMA : the journal of the American Medical AssociationMore Details
    22193234 Local and systemic cellular immunity in early renal artery atherosclerosis.Clinical journal of the American Society of Nephrology : CJASNMore Details
    22048682 Contribution of the human immunodeficiency virus/acquired immunodeficiency syndrome epidemic to de novo presentations of heart disease in the Heart of Soweto Study cohort.European heart journalMore Details
    22396788 Lymphocyte subpopulations in lymph nodes and peripheral blood: a comparison between patients with stable angina and acute coronary syndrome.PloS oneMore Details
    23180454 Impact of immunodepression and moderate alcohol consumption on coronary and other arterial disease events in an 11-year cohort of HIV-infected patients on antiretroviral therapy.BMJ openMore Details
    21251186 Fatty liver disease is associated with underlying cardiovascular disease in HIV-infected persons(*).HIV medicineMore Details
    21889313 Chlamydia pneumoniae heat shock protein 60 is associated with apoptotic signaling pathway in human atheromatous plaques of coronary artery disease patients.Journal of cardiologyMore Details
    21839249 Assessment of immunological markers as mediators of graft vasculopathy development in heart transplantation.Transplantation proceedingsMore Details
    21712519 The risk of incident coronary heart disease among veterans with and without HIV and hepatitis C.Circulation. Cardiovascular quality and outcomesMore Details
    21195379 Clinically significant incidental findings among human immunodeficiency virus-infected men during computed tomography for determination of coronary artery calcium.The American journal of cardiologyMore Details
    22055099 Interleukin-16 deficiency suppresses the development of chronic rejection in murine cardiac transplantation model.The Journal of heart and lung transplantation : the official publication of theMore Details
    21288058 Cost effectiveness of atazanavir-ritonavir versus lopinavir-ritonavir in treatment-naive human immunodeficiency virus-infected patients in the United States.Journal of medical economicsMore Details
    20131226 Cardiovascular disease in patients with inflammatory rheumatic disease is associated with up-regulation of markers of inflammation in cardiac microvessels and cardiomyocytes.Arthritis and rheumatismMore Details
    20543654 Initiation of antiretroviral therapy at higher nadir CD4+ T-cell counts is associated with reduced arterial stiffness in HIV-infected individuals."AIDS (London, England)"More Details
    20635253 One year survival of HIV-infected veterans with CD4 < 100 cells/mm3: data from a veteran cohort.AIDS careMore Details
    19996940 Increased prevalence of subclinical coronary atherosclerosis detected by coronary computed tomography angiography in HIV-infected men."AIDS (London, England)"More Details
    21048535 The indirect alloimmune response causes microvascular endothelial dysfunction-a possible role for alloantibody.TransplantationMore Details
    18427358 Plasma lipid-dependent and -independent effects of dietary soy protein and social status on atherogenesis in premenopausal monkeys: implications for postmenopausal atherosclerosis burden."Menopause (New York, N.Y.)"More Details
    18418233 Subclinic atherosclerosis and cardiovascular risk factors in HIV-infected children: PERI study.Coronary artery diseaseMore Details
    19059114 CXCL12 induction of inducible nitric oxide synthase in human CD8 T cells.The Journal of heart and lung transplantation : the official publication of theMore Details
    18393684 Human cord blood mononuclear cells decrease cytokines and inflammatory cells in acute myocardial infarction.Stem cells and developmentMore Details
    18923695 Dyslipidemia and cardiovascular disease risk factor management in HIV-1-infected subjects treated with HAART in the Spanish VACH cohort.The open AIDS journalMore Details
    17998494 Cystatin C level as a marker of kidney function in human immunodeficiency virus infection: the FRAM study.Archives of internal medicineMore Details
    17414708 "Riboflavin-mediated reduction of oxidant injury, rejection, and vasculopathy after cardiac allotransplantation."TransplantationMore Details
    17261328 Frequency of naturally-occurring regulatory T cells is reduced in patients with ST-segment elevation myocardial infarction.Thrombosis researchMore Details
    16983590 "Infectious agents, inflammation, and growth factors: how do they interact in the progression or stabilization of mild human atherosclerotic lesions?"Annals of vascular surgeryMore Details
    17015794 T-cell immunity to subclinical cytomegalovirus infection reduces cardiac allograft disease.CirculationMore Details
    17015796 The chemokine and chemokine receptor profile of infiltrating cells in the wall of arteries with cardiac allograft vasculopathy is indicative of a memory T-helper 1 response.CirculationMore Details
    16954132 Altered status of CD4(+)CD25(+) regulatory T cells in patients with acute coronary syndromes.European heart journalMore Details
    16601227 T cell recognition and killing of vascular smooth muscle cells in acute coronary syndrome.Circulation researchMore Details
    16424368 Interleukin 12 induces T-cell recruitment into the atherosclerotic plaque.Circulation researchMore Details
    16925217 Initial experience with bariatric surgery in asymptomatic human immunodeficiency virus-infected patients.Surgery for obesity and related diseases : official journal of the AmericanMore Details
    15585311 Altered trafficking of CD8+ memory T cells after implantation of rapamycin-eluting stents in patients with coronary artery disease.Immunology lettersMore Details
    16297172 The immune responses to human and microbial heat shock proteins in periodontal disease with and without coronary heart disease.Clinical and experimental immunologyMore Details
    15093715 Characterization of two populations of human coronary artery endothelial cells(1).The Journal of surgical researchMore Details
    15255036 "Cardiac, aortic, and pulmonary arteriopathy in HIV-infected children: the Prospective P2C2 HIV Multicenter Study."Pediatric and developmental pathology : the official journal of the Society forMore Details
    15023877 Progression of atherosclerosis as assessed by carotid intima-media thickness in patients with HIV infection.CirculationMore Details
    12736856 "[HIV-infection, HAART (highly-active antiretroviral therapy) and hyperlipidemia]."Deutsche medizinische Wochenschrift (1946)More Details
    12819520 Cardiovascular disease risk factors in HIV patients--association with antiretroviral therapy. Results from the DAD study."AIDS (London, England)"More Details
    12739013 Coronary artery disease in HIV infected patients.Intensive care medicineMore Details
    12816883 De novo expression of killer immunoglobulin-like receptors and signaling proteins regulates the cytotoxic function of CD4 T cells in acute coronary syndromes.Circulation researchMore Details
    12821825 Lipid profiles associated with antiretroviral drug choices.Current opinion in infectious diseasesMore Details
    12368204 The role of MIG/CXCL9 in cardiac allograft vasculopathy.The American journal of pathologyMore Details
    11863225 Fatal cytotoxic T-cell proliferation in chronic active Epstein-Barr virus infection in childhood.American journal of clinical pathologyMore Details
    11528596 CD8 T lymphocytes and macrophages infiltrate coronary artery aneurysms in acute Kawasaki disease.The Journal of infectious diseasesMore Details
    11504923 HIV envelope gp120 activates human arterial smooth muscle cells.Proceedings of the National Academy of Sciences of the United States of AmericaMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 96 unique genes interacted with CD4. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    UNC119 Affinity Capture-Western14757743 No
    SPG21 Affinity Capture-Western11113139|11113139 No
    PIP Reconstituted Complex10820003 No
    CCR5 Affinity Capture-Western10816381 CHD related
    CXCR4 Affinity Capture-Western10816381|15660419 CHD related
    LCK Affinity Capture-Western12007789|11854499|15047060|16888650|11854499,8104794 No
    IL16 Reconstituted Complex7910967 No
    BTRC Affinity Capture-Western9660940 No
    CD81 Affinity Capture-Western7636191 No
    CD82 Affinity Capture-Western7636191 No
    KCNAB2 Affinity Capture-Western12893943 No
    SYK Affinity Capture-Western7539035 No
    ZAP70 Affinity Capture-Western7539035 No
    UBC Affinity Capture-Western17937819|16497223|20442859|20974815|17686993|22090097 No
    EPS15 Affinity Capture-Western16497223 No
    nef FRET20179761|8599760 No
    vpu FRET20179761|20442859|22090097 No
    LRPPRC Affinity Capture-MS15047060 No
    EIF3C Affinity Capture-MS15047060 No
    TNPO1 Affinity Capture-MS15047060 No
    KPNB1 Affinity Capture-MS15047060 No
    EIF3B Affinity Capture-MS15047060 No
    HSP90AA1 Affinity Capture-MS15047060 CHD related
    MME Affinity Capture-MS15047060 No
    HSP90AB1 Affinity Capture-MS15047060 CHD related
    SSRP1 Affinity Capture-MS15047060 No
    ANXA6 Affinity Capture-MS15047060 No
    NCL Affinity Capture-MS15047060 No
    DDX3X Affinity Capture-MS15047060 No
    HSPA8 Affinity Capture-MS15047060 CHD related
    DDX5 Affinity Capture-MS15047060 No
    FARSB Affinity Capture-MS15047060 No
    EIF3D Affinity Capture-MS15047060 No
    HSPD1 Affinity Capture-MS15047060 CHD related
    ATP5A1 Affinity Capture-MS15047060 No
    CD4 Affinity Capture-MS15047060|12444132 CHD related
    VIM Affinity Capture-MS15047060 CHD related
    TUBB Affinity Capture-MS15047060 No
    HNRNPH1 Affinity Capture-MS15047060 No
    ENO1 Affinity Capture-MS15047060 CHD related
    EIF4A2 Affinity Capture-MS15047060 No
    GNAI2 Affinity Capture-MS15047060 No
    ANXA1 Affinity Capture-MS15047060 CHD related
    HNRNPA1 Affinity Capture-MS15047060 No
    ANXA2 Affinity Capture-MS15047060 No
    HNRNPD Affinity Capture-MS15047060 No
    VDAC2 Affinity Capture-MS15047060 No
    HNRNPA2B1 Affinity Capture-MS15047060 No
    EIF3I Affinity Capture-MS15047060 No
    GAPDH Affinity Capture-MS15047060 No
    RPLP0 Affinity Capture-MS15047060 No
    RPSA Affinity Capture-MS15047060 No
    NPM1 Affinity Capture-MS15047060 No
    VDAC1 Affinity Capture-MS15047060 No
    VDAC3 Affinity Capture-MS15047060 No
    PHB Affinity Capture-MS15047060 No
    RPL7 Affinity Capture-MS15047060 No
    DHRS2 Affinity Capture-MS15047060 No
    EEF1B2 Affinity Capture-MS15047060 No
    RPS9 Affinity Capture-MS15047060 No
    RPL18 Affinity Capture-MS15047060 No
    MYL12A Affinity Capture-MS15047060 No
    RPS10 Affinity Capture-MS15047060 No
    RPS19 Affinity Capture-MS15047060 No
    RPL22 Affinity Capture-MS15047060 No
    RPS12 Affinity Capture-MS15047060 No
    RPLP1 Affinity Capture-MS15047060 No
    STUB1 Affinity Capture-Western20974815 No
    NR3C1 Affinity Capture-Western16888650 CHD related
    HGS Affinity Capture-Western17686993 No
    VCP Affinity Capture-Western22090097 No
    CD44 in vitro7539755 CHD related
    CD38 in vitro7539755 CHD related
    PIK3R1 in vitro8246987 CHD related
    CD28 in vitro7539755 CHD related
    CTSD in vitro11581410 No
    TNFRSF10A in vivo7650480 No
    HLA-DQB1 in vitro11535811 No
    TFRC in vivo14705953 No
    HLA-DPA1 in vivo12899833 No
    FCGR3A in vitro11756173 CHD related
    IL2RA in vitro7539755 CHD related
    CD53 in vitro7539755 No
    CD5 in vitro7539755 No
    PTPRC FRET1834739 CHD related
    LGALS1 Affinity Capture-Western10490978 No
    env Reconstituted Complex1605591|2076345|15321703|2461565 No
    MAPK14 Biochemical Activity20530479 CHD related
    CD2 in vitro7539755 No
    DPP4 in vitro7539755 CHD related
    CXCL12 in vitro10600606 CHD related
    LAT in vivo10562325 No
    SELL in vitro7539755 CHD related
    PI4KA in vitro8246987 No
    HLA-DQA2 in vitro11535811 No
    MARCH4 in vitro14722266 No

    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB00098Antithymocyte globulinFor prevention of renal transplant rejection