How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: CD40

    Description: "CD40 molecule, TNF receptor superfamily member 5"

    Entrez Gene ID: 958

    SwissProt Acc Number: P25942

    RefSeq: NM_001250

    It was suspected to be CHD related:

    ..Increased serum concentrations of Soluble CD40 Ligand as a prognostic marker in patients with Acute Coronary Syndrome...

    From PMID: 23105840, in Journal Indian J Clin Biochem. , 2009


    There were 143 potential papers with CD40 and CHD.

    24026779 Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis.European heart journalMore Details
    24162006 Management of Kawasaki disease.Archives of disease in childhoodMore Details
    23954880 Single nucleotide polymorphism of CD40 in the 5'-untranslated region is associated with ischemic stroke.GeneMore Details
    23664202 Increased lysophosphatidic acid levels in culprit coronary arteries of patients with acute coronary syndrome.AtherosclerosisMore Details
    23086579 Type 2 diabetes as a modifier of fibrin clot properties in patients with coronary artery disease.Journal of thrombosis and thrombolysisMore Details
    23070634 Increased circulating soluble CD40 levels in patients with slow coronary flow phenomenon: an observational study.Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiologyMore Details
    23918902 Association between endothelial nitric oxide synthase gene polymorphism (-786T>C) and interleukin-6 in acute coronary syndrome.Human & experimental toxicologyMore Details
    23983803 The Effect of Sodium Tanshinone IIA Sulfate and Simvastatin on Elevated Serum Levels of Inflammatory Markers in Patients with Coronary Heart Disease: A Study Protocol for a Randomized Controlled Trial.Evidence-based complementary and alternative medicine : eCAMMore Details
    24117069 Anti-inflammatory effects of danshen on human vascular endothelial cells in culture.The American journal of Chinese medicineMore Details
    24071458 "Effect of omega-3 fatty acid supplementation on endothelial function, endogenous fibrinolysis and platelet activation in patients with a previous myocardial infarction: a randomised controlled trial."BMJ openMore Details
    22607887 Inflammatory and thrombotic markers in patients with ST-elevation myocardial infarction treated with thrombolysis and early PCI: a NORDISTEMI substudy.Thrombosis researchMore Details
    22809446 Which leukocyte subsets predict cardiovascular mortality? From the LUdwigshafen RIsk and Cardiovascular Health (LURIC) Study.AtherosclerosisMore Details
    21529993 CD40 ligand: a neo-inflammatory molecule in vascular diseases.ImmunobiologyMore Details
    22505696 Polymorphisms of the genes encoding CD40 and growth differentiation factor 15 and in the 9p21.3 region in patients with rheumatoid arthritis and cardiovascular disease.The Journal of rheumatologyMore Details
    22476993 Correlations between coronary plaque tissue composition assessed by virtual histology and blood levels of biomarkers for coronary artery disease.Yonsei medical journalMore Details
    21999662 Pentoxifylline decreases soluble CD40 ligand concentration and CD40 gene expression in coronary artery disease patients.Immunopharmacology and immunotoxicologyMore Details
    21334753 Pleiotropic effects of ezetimibe/simvastatin vs. high dose simvastatin.International journal of cardiologyMore Details
    22306248 Number of microparticles generated during acute myocardial infarction and stable angina correlates with platelet activation.Archives of medical researchMore Details
    22187234 Effects of combination therapy with celecoxib and doxycycline on neointimal hyperplasia and inflammatory biomarkers in coronary artery disease patients treated with bare metal stents.Yonsei medical journalMore Details
    22102482 Change of coronary flow velocity during the cold pressor test is related to endothelial markers in subjects with chest pain and a normal coronary angiogram.Clinical cardiologyMore Details
    22113625 Accelerated atherosclerosis in systemic lupus erythematosus: role of proinflammatory cytokines and therapeutic approaches.Current allergy and asthma reportsMore Details
    23095175 "Intracoronary monocyte chemoattractant protein 1 and vascular endothelial growth factor levels are associated with necrotic core, calcium and fibrous tissue atherosclerotic plaque components: an intracoronary ultrasound radiofrequency study."CardiologyMore Details
    22645426 CD40 Gene polymorphisms associated with susceptibility and coronary artery lesions of Kawasaki disease in the Taiwanese population.TheScientificWorldJournalMore Details
    21795297 "Effect of clopidogrel withdrawal on platelet reactivity and vascular inflammatory biomarkers 1 year after drug-eluting stent implantation: results of the prospective, single-centre CESSATION study."Heart (British Cardiac Society)More Details
    21741885 Vascular response to coronary artery stenting in mature and juvenile swine.Cardiovascular revascularization medicine : including molecular interventionsMore Details
    21855573 Soluble markers of inflammation are associated with Framingham scores in HIV-infected patients on suppressive antiretroviral therapy.The Journal of infectionMore Details
    21570531 "Peripheral artery disease, biomarkers, and darapladib."American heart journalMore Details
    21488132 Elevated soluble CD40 ligand in diabetic patients with painless myocardial infarction."BioFactors (Oxford, England)"More Details
    21414532 Composition of coronary thrombus in acute myocardial infarction.Journal of the American College of CardiologyMore Details
    20978895 Plasma concentrations of soluble CD40 ligand in smokers with acute myocardial infarction: a pilot study.Heart and vesselsMore Details
    21091218 The CD40 gene polymorphism rs1883832 is associated with risk of acute coronary syndrome in a Chinese case-control study.DNA and cell biologyMore Details
    21505504 Association of endothelial and oxidative stress with metabolic syndrome and subclinical atherosclerosis: multi-ethnic study of atherosclerosis.European journal of clinical nutritionMore Details
    20373128 Inflammatory response to percutaneous coronary intervention in stable coronary artery disease.Journal of thrombosis and thrombolysisMore Details
    21084403 Inflammatory and oxidative stress markers after intravenous insulin in percutaneous coronary intervention with stent in type 2 diabetes mellitus: a randomized controlled trial.The Journal of clinical endocrinology and metabolismMore Details
    22137075 Platelet reactivity in patients with chronic kidney disease receiving adjunctive cilostazol compared with a high-maintenance dose of clopidogrel: results of the effect of platelet inhibition according to clopidogrel dose in patients with chronic kidney disease (PIANO-2 CKD) randomized study.American heart journalMore Details
    21561895 Increased thrombin generation and platelet activation are associated with deficiency in high molecular weight multimers of von Willebrand factor in patients with moderate-to-severe aortic stenosis.Heart (British Cardiac Society)More Details
    21489606 Moderate consumption of red wine and human platelet responsiveness.Thrombosis researchMore Details
    21244217 The CD40-CD40L system in cardiovascular disease.Annals of medicineMore Details
    20137882 A common polymorphism in CD40 Kozak sequence (-1C/T) is associated with acute coronary syndrome.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieMore Details
    20552594 The relationship between CD40 gene polymorphism and unstable coronary atherosclerotic plaques.Clinical cardiologyMore Details
    20420893 Buyang Huanwu decoction ameliorates coronary heart disease with Qi deficiency and blood stasis syndrome by reducing CRP and CD40 in rats.Journal of ethnopharmacologyMore Details
    21742271 From atherosclerosis to acute coronary syndromes: the role of soluble CD40 ligand.Trends in cardiovascular medicineMore Details
    20456428 Association between serum levels of soluble CD40/CD40 ligand and organ damage in hypertensive patients.Clinical and experimental pharmacology & physiologyMore Details
    20304868 Levels of sCD40 ligand in chronic and acute coronary syndromes and its relation to angiographic extent of coronary arterial narrowing.AngiologyMore Details
    20394040 Changes in inflammatory biomarkers in patients treated with ticagrelor or clopidogrel.Clinical cardiologyMore Details
    19171469 "Markers of inflammation, thrombosis and endothelial activation correlate with carotid IMT regression in stable coronary disease after atorvastatin treatment.""Nutrition, metabolism, and cardiovascular diseases : NMCD"More Details
    19806256 The tumour necrosis factor superfamily ligand APRIL (TNFSF13) is released upon platelet activation and expressed in atherosclerosis.Thrombosis and haemostasisMore Details
    19380134 Intracoronary versus intravenous abciximab administration in patients with ST-elevation myocardial infarction undergoing thrombus aspiration during primary percutaneous coronary intervention--effects on soluble CD40 ligand concentrations.AtherosclerosisMore Details
    19700470 "Effect of irbesartan and enalapril in non-ST elevation acute coronary syndrome: results of the randomized, double-blind ARCHIPELAGO study."European heart journalMore Details
    19776136 Effect of cocoa powder on the modulation of inflammatory biomarkers in patients at high risk of cardiovascular disease.The American journal of clinical nutritionMore Details
    19732763 C-reactive protein but not soluble CD40 ligand and homocysteine is associated to common atherosclerotic risk factors in a cohort of coronary artery disease patients.Clinical biochemistryMore Details
    19477372 Inflammatory biomarkers in coronary artery disease.Journal of cardiologyMore Details
    19171341 Effect of aortic valve stenosis on haemostasis is independent from vascular atherosclerotic burden.AtherosclerosisMore Details
    18554599 "Polycystic ovary syndrome is associated with elevated plasma soluble CD40 ligand, a marker of coronary artery disease."Fertility and sterilityMore Details
    18445609 Association of angiotensin-converting enzyme gene 2350G>A polymorphism with myocardial infarction in a Chinese population.Clinical and applied thrombosis/hemostasis : official journal of theMore Details
    23105840 Increased serum concentrations of Soluble CD40 Ligand as a prognostic marker in patients with Acute Coronary Syndrome.Indian journal of clinical biochemistry : IJCBMore Details
    19101224 Prognostic value of a multimarker approach for patients presenting to hospital with acute chest pain.The American journal of cardiologyMore Details
    18931343 Systemic blood coagulation activation in acute coronary syndromes.BloodMore Details
    19656553 The role of platelets CD40 ligand (CD154) in acute coronary syndromes.Thrombosis researchMore Details
    19679244 The CD40/CD40 ligand system: linking inflammation with atherothrombosis.Journal of the American College of CardiologyMore Details
    18384393 "A rapid flow cytometric technique for the detection of platelet-monocyte complexes, activated platelets and platelet-derived microparticles."International journal of laboratory hematologyMore Details
    18511434 AP-1 and STAT-1 decoy oligodeoxynucleotides attenuate transplant vasculopathy in rat cardiac allografts.Cardiovascular researchMore Details
    18641098 "Soluble CD40 ligand, platelet surface CD40 ligand, and total platelet CD40 ligand in atrial fibrillation: relationship to soluble P-selectin, stroke risk factors, and risk factor intervention."ChestMore Details
    18481160 Genetic polymorphisms in the CD40 ligand gene and Kawasaki disease.Journal of clinical immunologyMore Details
    18781600 "Clinical implications of elevated serum interleukin-6, soluble CD40 ligand, metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 in patients with acute ST-segment elevation myocardial infarction."Clinical cardiologyMore Details
    18339606 Concurrent evaluation of novel cardiac biomarkers in acute coronary syndrome: myeloperoxidase and soluble CD40 ligand and the risk of recurrent ischaemic events in TACTICS-TIMI 18.European heart journalMore Details
    18574391 "Effect of clopidogrel on adhesion molecules, hemostasis, and fibrinolysis in coronary heart disease."Journal of cardiovascular pharmacologyMore Details
    18184662 Prognostic value of plasma soluble CD40 ligand in patients with chronic non-valvular atrial fibrillation."Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal "More Details
    17306806 Independent prognostic value of C-reactive protein and coronary artery disease extent in patients affected by unstable angina.AtherosclerosisMore Details
    19019166 Elevated circulating levels of soluble CD-40 ligand in haemodialysis patients with symptomatic coronary heart disease."Nephrology (Carlton, Vic.)"More Details
    19034329 Atorvastatin decreases elevated soluble CD40L in subjects at high cardiovascular risk. Atorvastatin on inflammatory markers study: a substudy of ACTFAST.Kidney international. SupplementMore Details
    18487475 "Hyperglycemia is associated with enhanced thrombin formation, platelet activation, and fibrin clot resistance to lysis in patients with acute coronary syndrome."Diabetes careMore Details
    18436114 "The effect of darapladib on plasma lipoprotein-associated phospholipase A2 activity and cardiovascular biomarkers in patients with stable coronary heart disease or coronary heart disease risk equivalent: the results of a multicenter, randomized, double-blind, placebo-controlled study."Journal of the American College of CardiologyMore Details
    18392332 Time course of prothrombotic and proinflammatory substance release after intracoronary stent implantation.Thrombosis and haemostasisMore Details
    18054068 Is soluble CD40 ligand a mediator of angiogenesis in patients with coronary artery disease?Thrombosis researchMore Details
    17726321 Soluble CD40 ligand as a predictor of coronary artery disease and long-term clinical outcomes in stable patients undergoing coronary angiography.CardiologyMore Details
    17984379 "Spontaneous atherothrombosis and medial degradation in Apoe-/-, Npc1-/- mice."CirculationMore Details
    17925605 "Monocyte-derived dendritic cells of patients with coronary artery disease show an increased expression of costimulatory molecules CD40, CD80 and CD86 in vitro."Coronary artery diseaseMore Details
    17908707 Platelet activation in coronary artery disease: intracardiac vs peripheral venous levels and the effects of angioplasty.ChestMore Details
    17384009 Multiple biomarker use for detection of adverse events in patients presenting with symptoms suggestive of acute coronary syndrome.Clinical chemistryMore Details
    17221325 Effects of low osmolar contrast (iomeprol) on haemorheology and platelet activation in patients with coronary artery disease.Journal of thrombosis and thrombolysisMore Details
    17495016 Increased plasma concentrations of soluble CD40 ligand in acute coronary syndrome depend on in vitro platelet activation.Clinical chemistryMore Details
    16494885 CD40-CD154 expression in calcified and non-calcified coronary lesions of patients with chronic renal failure.AtherosclerosisMore Details
    17326063 Transcoronary concentration gradient of sCD40L and hsCRP in patients with coronary heart disease.Clinical cardiologyMore Details
    17434456 Depression and inflammation in patients with coronary heart disease: findings from the Heart and Soul Study.Biological psychiatryMore Details
    17645592 Homocysteine-lowering therapy does not affect inflammatory markers of atherosclerosis in patients with stable coronary artery disease.Journal of internal medicineMore Details
    17371489 Indices of platelet activation and the stability of coronary artery disease.Journal of thrombosis and haemostasis : JTHMore Details
    17337289 Influence of sample type on soluble CD40 ligand assessment in patients with acute coronary syndromes.Thrombosis researchMore Details
    17521712 Soluble CD40 ligand:interleukin-10 ratio predicts in-hospital adverse events in patients with ST-segment elevation myocardial infarction.Thrombosis researchMore Details
    17365991 High plasma levels of CD40 are associated with low coenzyme Q and vitamin E content of low-density lipoprotein in healthy men.Scandinavian journal of clinical and laboratory investigationMore Details
    16376442 Soluble CD40 ligand and interleukin-6 in the coronary circulation after acute myocardial infarction.International journal of cardiologyMore Details
    17009241 The -786C/T single-nucleotide polymorphism in the promoter of the gene for endothelial nitric oxide synthase: insensitivity to physiologic stimuli as a risk factor for rheumatoid arthritis.Arthritis and rheumatismMore Details
    17056326 Humoral and cellular factors responsible for coronary collateral formation.The American journal of cardiologyMore Details
    16961584 The potential role of antiplatelet agents in modulating inflammatory markers in atherothrombosis.Journal of thrombosis and haemostasis : JTHMore Details
    16527885 Influence of sample type and storage conditions on soluble CD40 ligand assessment.Clinical chemistryMore Details
    16503253 CD40 ligand and risk of ischemic stroke or coronary events in patients with chronic coronary heart disease.International journal of cardiologyMore Details
    16246439 Anti-inflammatory and metabolic effects of candesartan in hypertensive patients.International journal of cardiologyMore Details
    16504636 Variants of the CD40 gene but not of the CD40L gene are associated with coronary artery calcification in the Diabetes Heart Study (DHS).American heart journalMore Details
    16860169 Randomized comparison of the effects of ASA plus clopidogrel versus ASA alone on early platelet activation in acute coronary syndromes with elevated high-sensitivity C-reactive protein and soluble CD40 ligand levels.Clinical therapeuticsMore Details
    16690490 Risk factor analysis of plasma cytokines in patients with coronary artery disease by a multiplexed fluorescent immunoassay.American journal of clinical pathologyMore Details
    16360159 "Is there more than C-reactive protein and fibrinogen? The prognostic value of soluble CD40 ligand, interleukin-6 and oxidized low-density lipoprotein with respect to coronary and cerebral vascular disease."AtherosclerosisMore Details
    16442363 Usefulness of preprocedural soluble CD40 ligand for predicting restenosis after percutaneous coronary intervention in patients with stable coronary artery disease.The American journal of cardiologyMore Details
    16368305 "Effect of atorvastatin on circulating proinflammatory T-lymphocyte subsets and soluble CD40 ligand in patients with stable coronary artery disease--a randomized, placebo-controlled study."American heart journalMore Details
    16442924 Effects of clopidogrel on soluble CD40 ligand and on high-sensitivity C-reactive protein in patients with stable coronary artery disease.American heart journalMore Details
    16182391 Coagulation activation and expression of CD40 ligand on platelets upon in vitro lipopolysaccharide-challenge in patients with unstable angina.International journal of cardiologyMore Details
    16904975 CD40 ligand increases expression of its receptor CD40 in human coronary artery endothelial cells.SurgeryMore Details
    16839837 The presence of metabolic syndrome is independently associated with elevated serum CD40 ligand and disease severity in patients with symptomatic coronary artery disease.Metabolism: clinical and experimentalMore Details
    16640741 Traditional risk factor assessment does not capture the extent of cardiovascular risk in systemic lupus erythematosus.Internal medicine journalMore Details
    17945659 Soluble CD40L versus myocyte enhancer factor: predicting a prominent marker for cardiovascular disease.Conference proceedings : ... Annual International Conference of the IEEEMore Details
    16356539 Circulating CD40 ligand is elevated only in patients with more advanced symptomatic peripheral arterial diseases.Thrombosis researchMore Details
    17060099 Myocardial perfusion reserve in cardiovascular magnetic resonance: Correlation to coronary microvascular dysfunction.Journal of cardiovascular magnetic resonance : official journal of the SocietyMore Details
    19804105 The use of MCP-1 and soluble CD40 ligand in a pathophysiology-guided approach to the management of coronary artery disease.Future cardiologyMore Details
    16230499 Immunoglobulin M-to-immunoglobulin G anti-human leukocyte antigen class II antibody switching in cardiac transplant recipients is associated with an increased risk of cellular rejection and coronary artery disease.CirculationMore Details
    16159609 The relationship between soluble CD40 ligand levels and Framingham coronary heart disease risk score in healthy volunteers.AtherosclerosisMore Details
    16041401 Effect of clopidogrel on the expression of inflammatory markers in rabbit ischemic coronary artery.British journal of pharmacologyMore Details
    16109925 "Associations between soluble CD40 ligand, atherosclerosis risk factors, and subclinical atherosclerosis: results from the Dallas Heart Study.""Arteriosclerosis, thrombosis, and vascular biology"More Details
    16275179 "Plasma, serum, and platelet expression of CD40 ligand in adults with cardiovascular disease."The American journal of cardiologyMore Details
    16303639 Soluble CD40 ligand levels in patients with hypertension."Clinical and experimental hypertension (New York, N.Y. : 1993)"More Details
    16314905 Inverse correlation between soluble CD40 ligand and soluble CD40 is absent in patients with unstable angina.Heart and vesselsMore Details
    15774573 Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome.Clinical chemistryMore Details
    15883614 Inflammatory biomarkers and statins."Drugs of today (Barcelona, Spain : 1998)"More Details
    16018843 Relation of platelet activation to coronary angiographic severity and collateralization.The American journal of cardiologyMore Details
    16091870 [The role of inflammation in the pathophysiology of acute coronary syndromes].Wiener klinische WochenschriftMore Details
    16113803 Early antithrombotic and anti-inflammatory effects of simvastatin versus fenofibrate in patients with hypercholesterolemia.Thrombosis and haemostasisMore Details
    15653020 "Pregnancy-associated plasma protein-A levels in patients with acute coronary syndromes: comparison with markers of systemic inflammation, platelet activation, and myocardial necrosis."Journal of the American College of CardiologyMore Details
    15642557 "Effects of tirofiban and statins on high-sensitivity C-reactive protein, interleukin-6, and soluble CD40 ligand following percutaneous coronary interventions in patients with stable coronary artery disease."The American journal of cardiologyMore Details
    15687128 Short-term treatment with atorvastatin reduces platelet CD40 ligand and thrombin generation in hypercholesterolemic patients.CirculationMore Details
    15670038 GPIIb-IIIa antagonists reduce thromboinflammatory processes in patients with acute coronary syndromes undergoing percutaneous coronary intervention.Journal of thrombosis and haemostasis : JTHMore Details
    16054454 "Plasma matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-2, and CD40 ligand levels in patients with stable coronary artery disease."The American journal of cardiologyMore Details
    16112968 Markers for early detection of cardiac diseases.Scandinavian journal of clinical and laboratory investigation. SupplementumMore Details
    15280513 CD40 ligand: a novel target in the fight against cardiovascular disease.The Annals of pharmacotherapyMore Details
    15528935 "Pathogen burden, inflammation, proliferation and apoptosis in human in-stent restenosis. Tissue characteristics compared to primary atherosclerosis."Journal of vascular researchMore Details
    15115688 The effect of elevated serum soluble CD40 ligand on the prognostic value in patients with acute coronary syndromes.Clinica chimica acta; international journal of clinical chemistryMore Details
    15172670 Pathophysiology and biochemistry of cardiovascular disease.Current opinion in genetics & developmentMore Details
    15186959 Effects of heparin-mediated extracorporeal low-density lipoprotein precipitation beyond lowering proatherogenic lipoproteins--reduction of circulating proinflammatory and procoagulatory markers.AtherosclerosisMore Details
    15599673 [Acute coronary syndrome and inflammation. Biomarkers for diagnostics and risk stratification].HerzMore Details
    15367912 CD40 ligand gene and Kawasaki disease.European journal of human genetics : EJHGMore Details
    15552272 Time course of systemic markers of inflammation in patients presenting with acute coronary syndromes.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    12952835 Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes.CirculationMore Details
    12912804 Soluble CD40L: risk prediction after acute coronary syndromes.CirculationMore Details
    12646667 Soluble CD40 ligand in acute coronary syndromes.The New England journal of medicineMore Details
    12624635 Enzyme immunoassay detection of platelet-derived microparticles and RANTES in acute coronary syndrome.Thrombosis and haemostasisMore Details
    12695287 Effect of rosiglitazone treatment on soluble CD40L in patients with type 2 diabetes and coronary artery disease.CirculationMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 43 unique genes interacted with CD40. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    UGGT1 Affinity Capture-MS17353931 No
    CALR Affinity Capture-MS17353931 No
    SGK1 Affinity Capture-MS17353931 No
    USP15 Affinity Capture-MS17353931 No
    RFC5 Affinity Capture-MS17353931 No
    ERP44 Affinity Capture-MS17353931 No
    POLR2H Affinity Capture-MS17353931 No
    SLC30A7 Affinity Capture-MS17353931 No
    TXN Affinity Capture-MS17353931 CHD related
    DDX3X Affinity Capture-MS17353931 No
    RNF219 Affinity Capture-MS17353931 No
    SLC39A7 Affinity Capture-MS17353931 No
    FBL Affinity Capture-MS17353931 No
    RIPK2 Affinity Capture-Western9642260 No
    TRAF3 Reconstituted Complex9990007|7527023|7527023|7527023|10984535|9384571|7859281|16260598|9718306|11562359|21041727|14517219|9168896|19667091|7530216|7530216|12637493|10352240 No
    TRAF5 Reconstituted Complex9990007|8790348|11562359|21041727|9511754 CHD related
    TRAF6 Reconstituted Complex9990007|9384571|16260598|9718306|21041727|12637493|20449947|20449947 No
    TDP2 Two-hybrid10764746|10764746 No
    MS4A1 Affinity Capture-Western9933087 No
    XRCC6 Reconstituted Complex10514012 No
    XRCC5 Reconstituted Complex10514012 No
    HSPA4 Reconstituted Complex12356871|12356871|12356871 No
    TRAF1 Affinity Capture-Western9718306 CHD related
    BIRC2 Affinity Capture-Western11562359|21041727|11562359 No
    TRAF4 Affinity Capture-Western11562359 No
    PIK3CA Affinity Capture-Western12637493 CHD related
    CBL Affinity Capture-Western12637493|12637493 No
    MAP3K8 Affinity Capture-Western15670770|15670770 No
    CAV1 in vivo14665433 CHD related
    IL4R in vitro;in vivo12207328 CHD related
    PIK3R1 in vitro12637493 CHD related
    BIRC3 in vitro11562359 No
    HSPA8 in vivo12356871 CHD related
    JAK3 in vitro9133417,10395671 No
    NCOA6 Reconstituted Complex10847592 No
    TRAF2 Co-crystal Structure10411888|12220533|10411888,16260598 No
    SUMO1 Two-hybrid8906799 No
    TRAF3IP2 Affinity Capture-Western12089335|12089335 No
    CDC40 Affinity Capture-MS20614026|20614026 No
    TANK Affinity Capture-Western17878343 No
    CD40LG in vitro;in vivo10647992,7516405,7543281 CHD related
    TTRAP in vivo;yeast 2-hybrid10764746 No
    NSMAF in vitro10601289 No

    Involved FDA drugs

    There was no drug associated with CD40