Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)
Website using assistance : Leihong Wu (11019004@zju.edu.cn)
Coronary Heart Disease Research Platform
Description: CD63 molecule
Entrez Gene ID: 967
SwissProt Acc Number: P08962
RefSeq: NM_001040034
It was suspected to be CHD related:
..The CD62P and CD63 expressions on platelets were significantly lower in the patients with pre-existing statin use compared to the patients without pre-existing statin use on Day 1 post-stroke (p < 0.05)..
From PMID: 21740551, in Journal Crit Care. , 2011There were 10 potential papers with CD63 and CHD.
| PMID | Title | Journals | Details |
|---|---|---|---|
| 24144446 | Oxidized low-density lipoprotein-induced CD147 expression and its inhibition by high-density lipoprotein on platelets in vitro. | Thrombosis research | More Details |
| 21701167 | Early impact of prescription Omega-3 fatty acids on platelet biomarkers in patients with coronary artery disease and hypertriglyceridemia. | Cardiology | More Details |
| 21740551 | Statin pre-treatment is associated with lower platelet activity and favorable outcome in patients with acute non-cardio-embolic ischemic stroke. | "Critical care (London, England)" | More Details |
| 18618353 | "Soluble, platelet-bound, and total P-selectin as indices of platelet activation in congestive heart failure." | Annals of medicine | More Details |
| 18217151 | Impact of cytochrome P450 3A4-metabolized statins on the antiplatelet effect of a 600-mg loading dose clopidogrel and on clinical outcome in patients undergoing elective coronary stent placement. | Thrombosis and haemostasis | More Details |
| 16856976 | Clopidogrel increases expression of chemokines in peripheral blood mononuclear cells in patients with coronary artery disease: results of a double-blind placebo-controlled study. | Journal of thrombosis and haemostasis : JTH | More Details |
| 16194867 | Elevated platelet microparticles in stable coronary artery disease are unrelated to disease severity or to indices of inflammation. | Platelets | More Details |
| 15610084 | Effects of Helicobacter pylori eradication on platelet activation and disease recurrence in patients with acute coronary syndromes. | Helicobacter | More Details |
| 11579350 | Uniform platelet activation exists before coronary stent implantation despite aspirin therapy. | American heart journal | More Details |
| 11061584 | Paroxetine decreases platelet serotonin storage and platelet function in human beings. | Clinical pharmacology and therapeutics | More Details |
NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.
There were totally 19 unique genes interacted with CD63. Show PPI network
| Gene name | Interaction type | reference PMID | CHD relation |
|---|---|---|---|
| CD9 | Affinity Capture-Western | 8630057|8630057,11204565,12175627 | CHD related |
| PTGFRN | Affinity Capture-Western | 11278880 | No |
| ITGB1 | Affinity Capture-Western | 12175627 | CHD related |
| HLA-DRA | Affinity Capture-Western | 9759843|9759843 | No |
| HLA-DMB | Affinity Capture-Western | 9759843|9759843 | No |
| HLA-DOB | Affinity Capture-Western | 9759843 | No |
| gag | Co-fractionation | 10708443 | No |
| CD81 | Co-fractionation | 16533950 | No |
| UBC | Affinity Capture-Western | 19246649 | No |
| env | Co-fractionation | 10708443 | No |
| TIMP1 | in vivo;yeast 2-hybrid | 16917503 | CHD related |
| ITGA6 | in vitro | 7629079 | No |
| KIT | Affinity Capture-Western | 12036870 | No |
| CD82 | Affinity Capture-Western | 9759843|9759843 | No |
| SRF | Two-hybrid | 9271374 | CHD related |
| RNF13 | Co-localization | 19292867 | No |
| ATP6V1B1 | Affinity Capture-MS | 21674799 | No |
| AP4M1 | yeast 2-hybrid | 10436028 | No |
| PI4K2A | in vivo | 9006891,11113129 | No |
There was no drug associated with CD63