How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: CD63

    Description: CD63 molecule

    Entrez Gene ID: 967

    SwissProt Acc Number: P08962

    RefSeq: NM_001040034

    It was suspected to be CHD related:

    ..The CD62P and CD63 expressions on platelets were significantly lower in the patients with pre-existing statin use compared to the patients without pre-existing statin use on Day 1 post-stroke (p < 0.05)..

    From PMID: 21740551, in Journal Crit Care. , 2011


    There were 10 potential papers with CD63 and CHD.

    24144446 Oxidized low-density lipoprotein-induced CD147 expression and its inhibition by high-density lipoprotein on platelets in vitro.Thrombosis researchMore Details
    21701167 Early impact of prescription Omega-3 fatty acids on platelet biomarkers in patients with coronary artery disease and hypertriglyceridemia.CardiologyMore Details
    21740551 Statin pre-treatment is associated with lower platelet activity and favorable outcome in patients with acute non-cardio-embolic ischemic stroke."Critical care (London, England)"More Details
    18618353 "Soluble, platelet-bound, and total P-selectin as indices of platelet activation in congestive heart failure."Annals of medicineMore Details
    18217151 Impact of cytochrome P450 3A4-metabolized statins on the antiplatelet effect of a 600-mg loading dose clopidogrel and on clinical outcome in patients undergoing elective coronary stent placement.Thrombosis and haemostasisMore Details
    16856976 Clopidogrel increases expression of chemokines in peripheral blood mononuclear cells in patients with coronary artery disease: results of a double-blind placebo-controlled study.Journal of thrombosis and haemostasis : JTHMore Details
    16194867 Elevated platelet microparticles in stable coronary artery disease are unrelated to disease severity or to indices of inflammation.PlateletsMore Details
    15610084 Effects of Helicobacter pylori eradication on platelet activation and disease recurrence in patients with acute coronary syndromes.HelicobacterMore Details
    11579350 Uniform platelet activation exists before coronary stent implantation despite aspirin therapy.American heart journalMore Details
    11061584 Paroxetine decreases platelet serotonin storage and platelet function in human beings.Clinical pharmacology and therapeuticsMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 19 unique genes interacted with CD63. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    CD9 Affinity Capture-Western8630057|8630057,11204565,12175627 CHD related
    PTGFRN Affinity Capture-Western11278880 No
    ITGB1 Affinity Capture-Western12175627 CHD related
    HLA-DRA Affinity Capture-Western9759843|9759843 No
    HLA-DMB Affinity Capture-Western9759843|9759843 No
    HLA-DOB Affinity Capture-Western9759843 No
    gag Co-fractionation10708443 No
    CD81 Co-fractionation16533950 No
    UBC Affinity Capture-Western19246649 No
    env Co-fractionation10708443 No
    TIMP1 in vivo;yeast 2-hybrid16917503 CHD related
    ITGA6 in vitro7629079 No
    KIT Affinity Capture-Western12036870 No
    CD82 Affinity Capture-Western9759843|9759843 No
    SRF Two-hybrid9271374 CHD related
    RNF13 Co-localization19292867 No
    ATP6V1B1 Affinity Capture-MS21674799 No
    AP4M1 yeast 2-hybrid10436028 No
    PI4K2A in vivo9006891,11113129 No

    Involved FDA drugs

    There was no drug associated with CD63