How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: CD68

    Description: CD68 molecule

    Entrez Gene ID: 968

    SwissProt Acc Number: P34810

    RefSeq: NM_001040059

    It was supported literatures to be a novel CHD related gene:

    ..The number of CD68+ cells in epicardial adipose tissue of group II was significantly higher than that in subcutaneous adipose tissue..

    From PMID: 21063839, in Journal J Huazhong Univ Sci Technolog Med Sci. , 2010


    References

    There were 35 potential papers with CD68 and CHD.

    PMIDTitleJournalsDetails
    22955009 "Mediastinal adipose tissue expresses a pathogenic profile of 11 beta-hydroxysteroid dehydrogenase Type 1, glucocorticoid receptor, and CD68 in patients with coronary artery disease."Cardiovascular pathology : the official journal of the Society for CardiovascularMore Details
    23321460 14C-Methionine uptake as a potential marker of inflammatory processes after myocardial ischemia and reperfusion."Journal of nuclear medicine : official publication, Society of Nuclear Medicine"More Details
    23429367 Macrophage heterogeneity of culprit coronary plaques in patients with acute myocardial infarction or stable angina.American journal of clinical pathologyMore Details
    23639635 Tissue kallikrein is related to the severity of coronary artery disease.Clinica chimica acta; international journal of clinical chemistryMore Details
    23744617 Late-phase inflammatory response as a feature of in-stent restenosis after drug-eluting stent implantation.Coronary artery diseaseMore Details
    23007990 11beta-hydroxysteroid dehydrogenase type 1 gene expression is increased in ascending aorta tissue of metabolic syndrome patients with coronary artery disease.Genetics and molecular research : GMRMore Details
    23009206 The role of mediastinal adipose tissue 11beta-hydroxysteroid d ehydrogenase type 1 and glucocorticoid expression in the development of coronary atherosclerosis in obese patients with ischemic heart disease.Cardiovascular diabetologyMore Details
    21345877 "Comparison of ADAMTS-1, -4 and -5 expression in culprit plaques between acute myocardial infarction and stable angina."Journal of clinical pathologyMore Details
    21388659 Activated inflammatory cells participate in thrombus size through tissue factor and plasminogen activator inhibitor-1 in acute coronary syndrome: Immunohistochemical analysis.Thrombosis researchMore Details
    20637465 "Expression of Chr9p21 genes CDKN2B (p15(INK4b)), CDKN2A (p16(INK4a), p14(ARF)) and MTAP in human atherosclerotic plaque."AtherosclerosisMore Details
    21063839 Roles of human epicardial adipose tissue in coronary artery atherosclerosis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua More Details
    19926621 Coronary intimal thickening in newborn babies and <or=1-year-old infants.AngiologyMore Details
    20131226 Cardiovascular disease in patients with inflammatory rheumatic disease is associated with up-regulation of markers of inflammation in cardiac microvessels and cardiomyocytes.Arthritis and rheumatismMore Details
    20609760 Inhibitory effects of calcitonin gene-related peptides on experimental vein graft disease.The Annals of thoracic surgeryMore Details
    21052019 Effects of zoledronate in the repair of chronically infarcted rat myocardium.Journal of cardiovascular pharmacologyMore Details
    20188594 Deposition of C4d and C3d in cardiac transplants: a factor in the development of coronary artery vasculopathy.The Journal of heart and lung transplantation : the official publication of theMore Details
    19103987 Activated endocannabinoid system in coronary artery disease and antiinflammatory effects of cannabinoid 1 receptor blockade on macrophages.CirculationMore Details
    19389562 Thin-walled microvessels in human coronary atherosclerotic plaques show incomplete endothelial junctions relevance of compromised structural integrity for intraplaque microvascular leakage.Journal of the American College of CardiologyMore Details
    18427358 Plasma lipid-dependent and -independent effects of dietary soy protein and social status on atherogenesis in premenopausal monkeys: implications for postmenopausal atherosclerosis burden."Menopause (New York, N.Y.)"More Details
    17963771 Myeloid lineage of high proliferative potential human smooth muscle outgrowth cells circulating in blood and vasculogenic smooth muscle-like cells in vivo.AtherosclerosisMore Details
    18514988 Associations of glomerular number and birth weight with clinicopathological features of African Americans and whites.American journal of kidney diseases : the official journal of the National KidneyMore Details
    17878224 Expression of adrenomedullin in human epicardial adipose tissue: role of coronary status.American journal of physiology. Endocrinology and metabolismMore Details
    17123106 A comparison of pathomolecular markers of fibrosis and morphology in kidney from autopsies of African Americans and whites.Virchows Archiv : an international journal of pathologyMore Details
    17174298 Ticlopidine attenuates progression of atherosclerosis in apolipoprotein E and low density lipoprotein receptor double knockout mice.European journal of pharmacologyMore Details
    16983590 "Infectious agents, inflammation, and growth factors: how do they interact in the progression or stabilization of mild human atherosclerotic lesions?"Annals of vascular surgeryMore Details
    17015796 The chemokine and chemokine receptor profile of infiltrating cells in the wall of arteries with cardiac allograft vasculopathy is indicative of a memory T-helper 1 response.CirculationMore Details
    16545643 Cellular immunostaining of angiotensin-converting enzyme in human coronary atherosclerotic plaques.Journal of the American College of CardiologyMore Details
    16386237 Effects of cytochalasin D-eluting stents on intimal hyperplasia in a porcine coronary artery model.Cardiovascular researchMore Details
    16872653 Intravascular two-dimensional tissue strain imaging.UltrasonicsMore Details
    16827927 Edge restenosis: impact of low dose irradiation on cell proliferation and ICAM-1 expression.BMC cardiovascular disordersMore Details
    15720417 The distribution of cardiac macrophages in myocardial ischaemia and cardiomyopathy.HistopathologyMore Details
    15910456 Neutrophilic involvement in the damage to coronary arteries in acute stage of Kawasaki disease.Pediatrics international : official journal of the Japan Pediatric SocietyMore Details
    15528935 "Pathogen burden, inflammation, proliferation and apoptosis in human in-stent restenosis. Tissue characteristics compared to primary atherosclerosis."Journal of vascular researchMore Details
    12748253 Granzyme B in atherosclerosis and transplant vascular disease: association with cell death and atherosclerotic disease severity.Modern pathology : an official journal of the United States and Canadian Academy More Details
    12434421 "Human atherosclerotic plaques express DC-SIGN, a novel protein found on dendritic cells and macrophages."The Journal of pathologyMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There was NO PPI interaction information about CD68



    Involved FDA drugs

    There was no drug associated with CD68