How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
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    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: CD80

    Description: CD80 molecule

    Entrez Gene ID: 941

    SwissProt Acc Number: P33681

    RefSeq: NM_005191

    It was supported literatures to be a novel CHD related gene:

    .."Patients with CAD, however, showed a significant upregulation of the costimulatory molecules CD80, CD86 and CD40 as compared with healthy controls."..

    From PMID: 17925605, in Journal Coron Artery Dis. , 2007


    There were 4 potential papers with CD80 and CHD.

    24107715 Kruppel-like factor 2 regulates dendritic cell activation in patients with acute coronary syndrome.Cellular physiology and biochemistry : international journal of experimentalMore Details
    18373609 Toll-like receptor-4 and mitogen-activated protein kinase signal system are involved in activation of dendritic cells in patients with acute coronary syndrome.ImmunologyMore Details
    17925605 "Monocyte-derived dendritic cells of patients with coronary artery disease show an increased expression of costimulatory molecules CD40, CD80 and CD86 in vitro."Coronary artery diseaseMore Details
    11238045 CD28-B7-mediated T cell costimulation in chronic cardiac allograft rejection: differential role of B7-1 in initiation versus progression of graft arteriosclerosis.The American journal of pathologyMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 4 unique genes interacted with CD80. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    CD80 Co-crystal Structure11279502|11279502 CHD related
    CTLA4 Reconstituted Complex7545666|7545666 CHD related
    CD28 Reconstituted Complex7545666|7545666 CHD related
    CD86 in vitro12606712 CHD related

    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB01281Abatacept"For the management of the signs and symptoms of moderate-to-severe active rheumatoid arthritis, inducing major clinical response, slowing the progression of structural damage, and improving physical function in adult patients. It is indicated both as a monotherapy and for use in combination with a continued regimen of DMARDs (not including TNF antagonists). Also used for the management of the signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis in children."L04AA24