How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: CD86

    Description: CD86 molecule

    Entrez Gene ID: 942

    SwissProt Acc Number: P42081

    RefSeq: NM_006889

    It was suspected to be CHD related:

    .."Finally, TLRs induce the expression of costimulatory molecules (e.g. B7-1 [CD80] and B7-2 [CD86]) necessary for sustained activation of adaptive immunity."..

    From PMID: 16002716, in Journal J Immunol. , 2005


    References

    There were 13 potential papers with CD86 and CHD.

    PMIDTitleJournalsDetails
    23901839 Immune-monitoring in Kawasaki disease patients treated with infliximab and intravenous immunoglobulin.Clinical and experimental immunologyMore Details
    22193234 Local and systemic cellular immunity in early renal artery atherosclerosis.Clinical journal of the American Society of Nephrology : CJASNMore Details
    21297489 Expression of circulatory dendritic cells and regulatory T-cells in patients with different subsets of coronary artery disease.Journal of cardiovascular pharmacologyMore Details
    21143200 Decreased numbers of peripheral blood dendritic cells in patients with coronary artery disease are associated with diminished plasma Flt3 ligand levels and impaired plasmacytoid dendritic cell function."Clinical science (London, England : 1979)"More Details
    21658276 Changes of dendritic cells and fractalkine in type 2 diabetic patients with unstable angina pectoris: a preliminary report.Cardiovascular diabetologyMore Details
    20888334 Expression of dendritic cell markers CD11c/BDCA-1 and CD123/BDCA-2 in coronary artery disease upon activation in whole blood.Journal of immunological methodsMore Details
    20230296 Absence of association between CD86 +1057G/A polymorphism and coronary artery disease.DNA and cell biologyMore Details
    20628522 Further increase in the expression of activation markers on monocyte-derived dendritic cells in coronary artery disease patients with ectasia compared to patients with coronary artery disease alone.Mediators of inflammationMore Details
    19751271 "In vivo extravasated human monocytes have an altered expression of CD16, HLA-DR, CD86, CD36 and CX(3)CR1."Scandinavian journal of immunologyMore Details
    19143751 Effects of pravastatin on the function of dendritic cells in patients with coronary heart disease.Basic & clinical pharmacology & toxicologyMore Details
    17925605 "Monocyte-derived dendritic cells of patients with coronary artery disease show an increased expression of costimulatory molecules CD40, CD80 and CD86 in vitro."Coronary artery diseaseMore Details
    12717692 Standardized immune monitoring for the prediction of infections after cardiopulmonary bypass surgery in risk patients."Cytometry. Part B, Clinical cytometry"More Details
    11238045 CD28-B7-mediated T cell costimulation in chronic cardiac allograft rejection: differential role of B7-1 in initiation versus progression of graft arteriosclerosis.The American journal of pathologyMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 7 unique genes interacted with CD86. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    UBC Affinity Capture-Western12582153|11756476|21896490 No
    MARCH1 Affinity Capture-Western21896490 No
    CD28 in vivo11021528,7513726 CHD related
    CD80 in vitro12606712 CHD related
    CD86 in vitro11279501 CHD related
    CTLA4 Co-crystal Structure11279501 CHD related
    MARCH8 Affinity Capture-Western12582153|12582153 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB00098Antithymocyte globulinFor prevention of renal transplant rejection
    approvedDB01281Abatacept"For the management of the signs and symptoms of moderate-to-severe active rheumatoid arthritis, inducing major clinical response, slowing the progression of structural damage, and improving physical function in adult patients. It is indicated both as a monotherapy and for use in combination with a continued regimen of DMARDs (not including TNF antagonists). Also used for the management of the signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis in children."L04AA24