How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: CD93

    Description: CD93 molecule

    Entrez Gene ID: 22918

    SwissProt Acc Number: Q9NPY3

    RefSeq: NM_012072

    It was supported literatures to be a novel CHD related gene:

    ..Plasma CD93 concentration is a potential novel biomarker for coronary artery disease...

    From PMID: 21332844, in Journal J Intern Med. , 2011


    There were 2 potential papers with CD93 and CHD.

    21332844 Plasma CD93 concentration is a potential novel biomarker for coronary artery disease.Journal of internal medicineMore Details
    18599554 Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia.European heart journalMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 18 unique genes interacted with CD93. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    MSN in vitro15819698 No
    COL4A3 in vitro1377218 No
    COL4A2 in vitro1377218 No
    COL4A1 in vitro1377218 CHD related
    COL4A4 in vitro9136074 No
    COL1A1 in vitro1377218 CHD related
    COL1A2 in vitro1377218 CHD related
    C1QA in vitro9476117 CHD related
    SCYL1 yeast 2-hybrid15459234 No
    RANBP1 yeast 2-hybrid15459234 No
    KNG1 Reconstituted Complex8710908|12213329,8710908 No
    MBL2 in vitro9476117 CHD related
    SFTPA2 in vitro9476117 No
    F12 in vitro11204562,8710908 CHD related
    COL4A5 in vitro;in vivo1377218 No
    COL4A6 in vitro;in vivo1377218 No
    KIR2DL2 in vitro9476117 No
    ARHGAP15 yeast 2-hybrid15459234 No

    Involved FDA drugs

    There was no drug associated with CD93