How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: CFH

    Description: complement factor H

    Entrez Gene ID: 3075

    SwissProt Acc Number: P08603

    RefSeq: NM_000186

    It was suspected to be CHD related:

    ..rs1410996 CFH polymorphism could be associated with both proliferative diabetic retinopathy and coronary artery disease in type 1 diabetes patients...

    From PMID: 23296223, in Journal An Sist Sanit Navar , 2012


    References

    There were 13 potential papers with CFH and CHD.

    PMIDTitleJournalsDetails
    23103884 Age-related macular degeneration and coronary heart disease: evaluation of genetic and environmental associations.European journal of medical geneticsMore Details
    23620142 Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.Human molecular geneticsMore Details
    20127520 Complement factor H Y402H gene polymorphism and coronary heart disease susceptibility: a meta-analysis.Molecular biology reportsMore Details
    20708732 "Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individuals."AtherosclerosisMore Details
    18604638 "Complement factor H Y402H polymorphism, plasma concentration and risk of coronary artery disease."Molecular biology reportsMore Details
    18292760 Association of the complement factor H Y402H polymorphism with cardiovascular disease is dependent upon hypertension status: The ARIC study.American journal of hypertensionMore Details
    17352366 Relationship between age-related macular degeneration-associated variants of complement factor H and LOC387715 with coronary artery disease.Mayo Clinic proceedings. Mayo ClinicMore Details
    17483111 Complement factor H (Y402H) polymorphism and risk of coronary heart disease in US men and women.European heart journalMore Details
    17396242 Lack of association between complement factor H polymorphisms and coronary artery disease or myocardial infarction."Journal of molecular medicine (Berlin, Germany)"More Details
    17472578 The common Y402H variant in complement factor H gene is not associated with susceptibility to myocardial infarction and its related risk factors."Clinical science (London, England : 1979)"More Details
    17877809 Genetic variants of complement factor H gene are not associated with premature coronary heart disease: a family-based study in the Irish population.BMC medical geneticsMore Details
    16987874 Genetic susceptibility to myocardial infarction and coronary artery disease.Human molecular geneticsMore Details
    16630992 A common polymorphism in the complement factor H gene is associated with increased risk of myocardial infarction: the Rotterdam Study.Journal of the American College of CardiologyMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 15 unique genes interacted with CFH. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    C3 Reconstituted Complex9291131|11367533,9988761 CHD related
    THBS1 in vitro15634279 CHD related
    ITGAM in vitro9558116 CHD related
    ADM in vitro11116141 CHD related
    HEM12 Far Western17959597 No
    GPM1 Far Western17959597 No
    NCL1 Far Western17959597 No
    HIP1 Far Western17959597 No
    CRP Reconstituted Complex10490997 CHD related
    SELL Reconstituted Complex10377245|10377245 CHD related
    GRB2 Two-hybrid18624398 CHD related
    PTX3 in vitro19050261 CHD related
    CFHR1 in vivo8663389 No
    CFI in vitro9291131,1401896 CHD related
    DMP1 in vitro11825898 No


    Involved FDA drugs

    There was no drug associated with CFH