How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: CFI

    Description: complement factor I

    Entrez Gene ID: 3426

    SwissProt Acc Number: P05156

    RefSeq: NM_000204

    It was supported literatures to be a novel CHD related gene:

    ..Complement factor 1 inhibitor improves cardiopulmonary function in neonatal cardiopulmonary bypass...

    From PMID: 17383361, in Journal Ann Thorac Surg. , 2007


    There were 33 potential papers with CFI and CHD.

    23886607 Prognostic relevance of coronary collateral function: confounded or causal relationship?Heart (British Cardiac Society)More Details
    24186565 The effect of heart rate reduction by ivabradine on collateral function in patients with chronic stable coronary artery disease.Heart (British Cardiac Society)More Details
    22584016 Theoretical study of the flow rate toward the right heart territory in case of total occlusion of the right coronary artery.Medical engineering & physicsMore Details
    23716567 Clinical parameters associated with collateral development in patients with chronic total coronary occlusion.Heart (British Cardiac Society)More Details
    23343686 Effects of coronary sinus occlusion on myocardial ischaemia in humans: role of coronary collateral function.Heart (British Cardiac Society)More Details
    22835408 Determinants of prognostically relevant intracoronary electrocardiogram ST-segment shift during coronary balloon occlusion.The American journal of cardiologyMore Details
    22633139 A more sensitive pressure-based index to estimate collateral blood supply in case of coronary three-vessel disease.Medical hypothesesMore Details
    23056467 Cause or effect of arteriogenesis: compositional alterations of microparticles from CAD patients undergoing external counterpulsation therapy.PloS oneMore Details
    21270076 Coronary collateral function in the transplanted heart: propensity score matching with coronary artery disease.Heart (British Cardiac Society)More Details
    21701169 Determinants of preformed collateral vessels in the human heart without coronary artery disease.CardiologyMore Details
    20584776 Instantaneous coronary collateral function during supine bicycle exercise.European heart journalMore Details
    20435184 Collateral pressure and flow in acute myocardial infarction with total coronary occlusion correlate with angiographic collateral grade and creatine kinase levels.American heart journalMore Details
    19897461 Coronary collateral growth by external counterpulsation: a randomised controlled trial.Heart (British Cardiac Society)More Details
    19770393 Myocardial salvage through coronary collateral growth by granulocyte colony-stimulating factor in chronic coronary artery disease: a controlled randomized trial.CirculationMore Details
    18728069 Non-invasive gene-expression-based detection of well-developed collateral function in individuals with and without coronary artery disease.Heart (British Cardiac Society)More Details
    19288205 Dimensions of social support and depression in patients at increased psychosocial risk recovering from myocardial infarction.International journal of behavioral medicineMore Details
    17207716 Coronary collateral function long after drug-eluting stent implantation.Journal of the American College of CardiologyMore Details
    17679611 Beneficial effect of recruitable collaterals: a 10-year follow-up study in patients with stable coronary artery disease undergoing quantitative collateral measurements.CirculationMore Details
    17456484 Recruitable collateral blood flow index predicts coronary instent restenosis after percutaneous coronary intervention.European heart journalMore Details
    17404157 Coronary collaterals remain recruitable after percutaneous intervention.CirculationMore Details
    17378780 Single transpulmonary thermodilution in off-pump coronary artery bypass grafting: haemodynamic changes and effects of different anaesthetic techniques.Acta anaesthesiologica ScandinavicaMore Details
    17235472 Does the beta-blocker nebivolol increase coronary flow reserve?Cardiovascular drugs and therapy / sponsored by the International Society ofMore Details
    16216859 Does a well developed collateral circulation predispose to restenosis after percutaneous coronary intervention? An intravascular ultrasound study.Heart (British Cardiac Society)More Details
    16207739 Collateral-flow measurements in humans by myocardial contrast echocardiography: validation of coronary pressure-derived collateral-flow assessment.European heart journalMore Details
    16162618 Influence of diabetes mellitus on coronary collateral flow: an answer to an old controversy.Heart (British Cardiac Society)More Details
    16256861 Safety and efficacy of subcutaneous-only granulocyte-macrophage colony-stimulating factor for collateral growth promotion in patients with coronary artery disease.Journal of the American College of CardiologyMore Details
    15184289 Circulating humoral factors and endothelial progenitor cells in patients with differing coronary collateral support.CirculationMore Details
    15120053 Coronary collateral perfusion in patients with coronary artery disease: effect of metoprolol.European heart journalMore Details
    12707241 Is there functional collateral flow during vascular occlusion in angiographically normal coronary arteries?CirculationMore Details
    14623811 Regression of collateral function after recanalization of chronic total coronary occlusions: a serial assessment by intracoronary pressure and Doppler recordings.CirculationMore Details
    14557690 Exercise-induced human coronary collateral function: quantitative assessment during acute coronary occlusions.CardiologyMore Details
    11486568 Sympathetic stimulation using the cold pressor test increases coronary collateral flow.Swiss medical weeklyMore Details
    11052842 Quantitatively assessed coronary collateral circulation and restenosis following percutaneous revascularization.European heart journalMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 2 unique genes interacted with CFI. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    C3 Biochemical Activity8648130|9291131|1401896,9291131 CHD related
    CFH in vitro9291131,1401896 CHD related

    Involved FDA drugs

    There was no drug associated with CFI