How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: CNR1

    Description: cannabinoid receptor 1 (brain)

    Entrez Gene ID: 1268

    SwissProt Acc Number: P21554

    RefSeq: NM_001160226

    It was suspected to be CHD related:

    ..The present findings suggest that the G1359A polymorphism of the CNR1 gene may be associated with the risk for developing CAD in the Chinese Han population...

    From PMID: 22029183, in Journal Clin Lab. , 2011


    References

    There were 2 potential papers with CNR1 and CHD.

    PMIDTitleJournalsDetails
    22138970 G1359A polymorphism in the cannabinoid receptor-1 gene is associated with the presence of coronary artery disease in patients with type 2 diabetes.Journal of investigative medicine : the official publication of the AmericanMore Details
    21633404 "Variants at the endocannabinoid receptor CB1 gene (CNR1) and insulin sensitivity, type 2 diabetes, and coronary heart disease.""Obesity (Silver Spring, Md.)"More Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 7 unique genes interacted with CNR1. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    GNAI1 Affinity Capture-Western11168387 CHD related
    GNAI2 Affinity Capture-Western11168387 No
    GNAI3 Affinity Capture-Western11168387 No
    RAP1GAP Affinity Capture-Western15657046 No
    GNA15 in vivo12095632 No
    HCRTR1 in vivo12690115 No
    MET in vitro11894096 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    illicit;approvedDB00470Dronabinol"For the treatment of anorexia associated with weight loss in patients with AIDS, and nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments"A04AD10
    approvedDB00486Nabilone"Used for the control of nausea and vomiting, caused by chemotherapeutic agents used in the treatment of cancer, in patients who have failed to respond adequately to conventional antiemetic treatments."A04AD11
    approvedDB06155Rimonabant"For use in conjunction with diet and exercise for patients with a body mass index greater than 30 kg/m<sup>2</sup>, or patients wih a BMI greater than 27 kg/m<sup>2</sup> with associated risk factors, such as type 2 diabetes or dyslipidaemia."A08AX01