How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: CORT

    Description: cortistatin

    Entrez Gene ID: 1325

    SwissProt Acc Number: O00230

    RefSeq: NM_001302

    It was supported literatures to be a novel CHD related gene:

    ..Patients with CHD have higher plasma levels of CST. CST may play an important role in the procedure of CHD.(CORT=cortistatin=CST)..

    From PMID: 19829669, in Journal Beijing Da Xue Xue Bao. , 2009


    References

    There were 2 potential papers with CORT and CHD.

    PMIDTitleJournalsDetails
    23287650 Adrenalectomy amplifies aldosterone induced injury in cardiovascular tissue: an effect attenuated by adrenally derived steroids.SteroidsMore Details
    20410198 Activation of mineralocorticoid receptors by exogenous glucocorticoids and the development of cardiovascular inflammatory responses in adrenalectomized rats.EndocrinologyMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 7 unique genes interacted with CORT. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    SSTR1 Protein-peptide9125122|9205124,9125122 No
    SSTR2 Protein-peptide9125122|9125122 No
    SSTR3 Protein-peptide9125122|9125122,9205124 No
    SSTR4 Protein-peptide9125122|9125122,9205124 No
    SSTR5 Protein-peptide9125122|9205124,9125122 No
    GHSR in vivo11227737 No
    MRGPRX2 in vivo12915402 No


    Involved FDA drugs

    There was no drug associated with CORT