How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: CRCL

    Description: Creatinine clearance QTL

    Entrez Gene ID: 261727

    SwissProt Acc Number:


    It was supported literatures to be a novel CHD related gene:

    ..Lower CrCl was also associated with more frequent death or myocardial infarction (MI) during the initial hospital stay (p = 0.001) and at 1 year (p < 0.001)..

    From PMID: 19463396, in Journal JACC Cardiovasc Interv. , 2009


    There were 47 potential papers with CRCL and CHD.

    23849305 Circulating levels of beta2-microglobulin and cystatin C are associated with left atrial size: additional link between the kidney and the heart.Clinical nephrologyMore Details
    23817344 Clinical Outcomes After Percutaneous Coronary Intervention in Patients With Mild Versus Moderate Renal Insufficiency at 30-Day and 1-Year Follow-up.American journal of therapeuticsMore Details
    22093591 "The evaluation of creatinine clearance, estimated glomerular filtration rate and serum creatinine in predicting contrast-induced acute kidney injury among patients undergoing percutaneous coronary intervention."Cardiovascular revascularization medicine : including molecular interventionsMore Details
    22969775 On-versus Off-Pump Coronary Artery Bypass Grafting: No Difference in Early Postoperative Kidney Function Based on TNF-alpha or C-Reactive Protein.Cardiorenal medicineMore Details
    21847773 Which method of estimating renal function is the best predictor of mortality after coronary artery bypass grafting?Netherlands heart journal : monthly journal of the Netherlands Society ofMore Details
    22152512 One-year clinical outcomes in patients with chronic renal failure treated by percutaneous coronary intervention with drug-eluting stent.Archives of cardiovascular diseasesMore Details
    21235779 Uromodulin concentrations are not associated with incident CKD among persons with coronary artery disease.BMC nephrologyMore Details
    21691204 Impact of renal dysfunction on the prognostic value of the TIMI risk score in patients with non-ST elevation acute coronary syndrome.Coronary artery diseaseMore Details
    19406493 Relationship between renal function and outcomes in high-risk patients with non-ST-segment elevation acute coronary syndromes: results from SYNERGY.International journal of cardiologyMore Details
    20334577 Comparison of methods for determination of glomerular filtration rate in hypertensive subjects with normal serum creatinine.Blood pressureMore Details
    20223530 Unfavourable interaction of microalbuminuria and mildly reduced creatinine clearance on aortic stiffness in essential hypertension.International journal of cardiologyMore Details
    20851872 Coronary microvascular function in early chronic kidney disease.Circulation. Cardiovascular imagingMore Details
    21184562 Diastolic heart failure versus diastolic dysfunction: difference in renal function.Clinical cardiologyMore Details
    20346309 Effect of renal function on ultrasonic coronary plaque characteristics in patients with acute myocardial infarction.The American journal of cardiologyMore Details
    18653250 Impact of moderate or severe renal insufficiency on long-term outcomes in patients undergoing drug-eluting stent based coronary intervention.International journal of cardiologyMore Details
    19540404 "Renal function, atherothrombosis extent, and outcomes in high-risk patients."American heart journalMore Details
    19463396 In-hospital and 1-year outcomes among percutaneous coronary intervention patients with chronic kidney disease in the era of drug-eluting stents: a report from the EVENT (Evaluation of Drug Eluting Stents and Ischemic Events) registry.JACC. Cardiovascular interventionsMore Details
    19017872 Impact of chronic kidney disease on major bleeding complications and mortality in patients with indication for oral anticoagulation undergoing coronary stenting.ChestMore Details
    19672119 Diminished benefits of drug-eluting stents versus bare metal stents in patients with severe renal insufficiency.Nephron. Clinical practiceMore Details
    18328840 "Impact of renal insufficiency on angiographic, procedural, and in-hospital outcomes following percutaneous coronary intervention."The American journal of cardiologyMore Details
    17399818 Mild to moderate renal impairment is associated with increased left ventricular mass.International journal of cardiologyMore Details
    18003663 Prognostic significance of renal function in patients undergoing dobutamine stress echocardiography."Nephrology, dialysis, transplantation : official publication of the European"More Details
    19021282 "A prospective, double-blind, randomized, controlled trial on the efficacy and cardiorenal safety of iodixanol vs. iopromide in patients with chronic kidney disease undergoing coronary angiography with or without percutaneous coronary intervention."Catheterization and cardiovascular interventions : official journal of theMore Details
    17336699 Kidney disease as a predictor of mortality in chronic spinal cord injury.American journal of kidney diseases : the official journal of the National KidneyMore Details
    17160550 Abnormal asymmetric dimethylarginine/nitric oxide balance in patients with documented coronary artery disease: relation to renal function and homocysteine.Journal of thrombosis and thrombolysisMore Details
    17499233 "Association of serum levels of glycated albumin, C-reactive protein and tumor necrosis factor-alpha with the severity of coronary artery disease and renal impairment in patients with type 2 diabetes mellitus."Clinical biochemistryMore Details
    17383292 Regional left ventricular function in individuals with mild to moderate renal insufficiency: the Multi-Ethnic Study of Atherosclerosis.American heart journalMore Details
    16716614 Occult renal impairment is common in patients with peripheral vascular disease and normal serum creatinine.European journal of vascular and endovascular surgery : the official journal ofMore Details
    16781361 Correlates of bleeding events among moderate- to high-risk patients undergoing percutaneous coronary intervention and treated with eptifibatide: observations from the PROTECT-TIMI-30 trial.Journal of the American College of CardiologyMore Details
    17159010 "Comparison of N-terminal pro-B-natriuretic peptide, C-reactive protein, and creatinine clearance for prognosis in patients with known coronary heart disease."Archives of internal medicineMore Details
    17161052 Early invasive treatment benefits patients with renal dysfunction in unstable coronary artery disease.American heart journalMore Details
    16644775 Fetuin-A and kidney function in persons with coronary artery disease--data from the Heart and Soul Study."Nephrology, dialysis, transplantation : official publication of the European"More Details
    16188511 Impact of renal function on coronary plaque morphology and morphometry in patients with chronic renal insufficiency as determined by intravascular ultrasound volumetric analysis.The American journal of cardiologyMore Details
    16030030 "Renal function, concomitant medication use and outcomes following acute coronary syndromes.""Nephrology, dialysis, transplantation : official publication of the European"More Details
    16209963 Outcomes in patients admitted for chest pain with renal failure and troponin I elevations.American heart journalMore Details
    15932908 Non-ST-segment elevation acute coronary syndrome in patients with renal dysfunction: benefit of low-molecular-weight heparin alone or with glycoprotein IIb/IIIa inhibitors on outcomes. The Global Registry of Acute Coronary Events.European heart journalMore Details
    15919303 Renal function after cardiac surgery off- versus on-pump coronary artery bypass: analysis using the Cockroft-Gault formula for estimating creatinine clearance.The Annals of thoracic surgeryMore Details
    15613068 Subclinical peripheral arterial disease in patients with chronic kidney disease: prevalence and related risk factors.Kidney international. SupplementMore Details
    15563478 Plasma concentrations of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events: more than simply a marker of glomerular filtration rate.Clinical chemistryMore Details
    16093217 Safety of bivalirudin during percutaneous coronary interventions in patients with abnormal renal function.International journal of cardiovascular interventionsMore Details
    15489091 Renal insufficiency as an independent predictor of mortality among women with heart failure.Journal of the American College of CardiologyMore Details
    15519008 Impact of mild or moderate chronic kidney disease on the frequency of restenosis: results from the PRESTO trial.Journal of the American College of CardiologyMore Details
    15220366 The effect of statins versus untreated dyslipidaemia on renal function in patients with coronary heart disease. A subgroup analysis of the Greek atorvastatin and coronary heart disease evaluation (GREACE) study.Journal of clinical pathologyMore Details
    14732743 High prevalence of peripheral arterial disease in persons with renal insufficiency: results from the National Health and Nutrition Examination Survey 1999-2000.CirculationMore Details
    15582311 Reduced glomerular filtration rate in asymptomatic diabetic patients: predictor of increased risk for cardiac events independent of albuminuria.Journal of the American College of CardiologyMore Details
    12660678 Impact of renal function on morbidity and mortality after percutaneous aortocoronary saphenous vein graft intervention.American heart journalMore Details
    14638545 Impact of renal insufficiency in patients undergoing primary angioplasty for acute myocardial infarction.CirculationMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There was NO PPI interaction information about CRCL

    Involved FDA drugs

    There was no drug associated with CRCL