How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: CRYZ

    Description: "crystallin, zeta (quinone reductase)"

    Entrez Gene ID: 1429

    SwissProt Acc Number: Q08257

    RefSeq: NM_001130042

    It was supported literatures to be a novel CHD related gene:

    .."Resistin is a polypeptide hormone that was reported to be associated with insulin resistance, inflammation and risk of type 2 diabetes and cardiovascular disease. Our results suggest that genetic variants in TYW3/CRYZ and NDST4 loci may be involved in the regulation of circulating resistin levels. "..

    From PMID: 22843503, in Journal Hum Mol Genet. , 2012


    References

    There were 1 potential papers with CRYZ and CHD.

    PMIDTitleJournalsDetails
    22843503 Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels.Human molecular geneticsMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 2 unique genes interacted with CRYZ. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    CRYAA in vitro11672428 No
    UBC Affinity Capture-MS21139048|21890473|21906983|22505724 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB00266DicumarolFor decreasing blood clotting. Often used along with heparin for treatment of deep vein thrombosis.B01AA01
    experimentalDB034612'-Monophosphoadenosine 5'-Diphosphoribose