How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: CXCL10

    Description: chemokine (C-X-C motif) ligand 10

    Entrez Gene ID: 3627

    SwissProt Acc Number: P02778

    RefSeq: NM_001565

    It was suspected to be CHD related:

    .."Patients with CAD showed higher constitutive expression of CCL2, CXCL8, CXCL9, CXCL10 and IFN-gamma mRNA and, after stimulation with oxLDL, higher expression of CCL2 and CXCL8 mRNA than the control group."..

    From PMID: 18617279, in Journal Int J Cardiol , 2009


    References

    There were 8 potential papers with CXCL10 and CHD.

    PMIDTitleJournalsDetails
    23933542 The 9p21 locus does not affect risk of coronary artery disease through induction of type 1 interferons.Journal of the American College of CardiologyMore Details
    24041790 Noncalcified Coronary Atherosclerotic Plaque and Immune Activation in HIV-Infected Women.The Journal of infectious diseasesMore Details
    21731663 Plasma chemokine levels are associated with the presence and extent of angiographic coronary collaterals in chronic ischemic heart disease.PloS oneMore Details
    19255340 Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells.CirculationMore Details
    18617279 "Differential expression of cytokines, chemokines and chemokine receptors in patients with coronary artery disease."International journal of cardiologyMore Details
    19421322 Atorvastatin reduces plasma levels of chemokine (CXCL10) in patients with Crohn's disease.PloS oneMore Details
    16682613 Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells.CirculationMore Details
    16456091 Molecular signatures determining coronary artery and saphenous vein smooth muscle cell phenotypes: distinct responses to stimuli."Arteriosclerosis, thrombosis, and vascular biology"More Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 6 unique genes interacted with CXCL10. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    CXCL10 in vitro12737818 CHD related
    VCAN in vitro11083865 CHD related
    Igfbp7 Reconstituted Complex12847218 No
    CXCR3 Reconstituted Complex12782716|12571234,10233762 CHD related
    DPP4 in vitro11390394 CHD related
    CCR3 in vitro11110785 CHD related


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    experimentalDB04487N-Methylleucine