How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: CXCR2

    Description: chemokine (C-X-C motif) receptor 2

    Entrez Gene ID: 3579

    SwissProt Acc Number: P25025

    RefSeq: NM_001168298

    It was supported literatures to be a novel CHD related gene:

    .."mRNA levels for CXCR1 and CXCR2 are increased in blood in males with obstructive CAD and decreased in patients with improved perfusion, suggesting that these genes may serve as markers of disease severity and progression."..

    From PMID: 21915051, in Journal Coron Artery Dis. , 2011


    References

    There were 5 potential papers with CXCR2 and CHD.

    PMIDTitleJournalsDetails
    21915051 Elevated expression of the interleukin-8 receptors CXCR1 and CXCR2 in peripheral blood cells in obstructive coronary artery disease.Coronary artery diseaseMore Details
    20378860 "Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium."Circulation researchMore Details
    19229069 Human IL-8 regulates smooth muscle cell VCAM-1 expression in response to endothelial cells exposed to atheroprone flow."Arteriosclerosis, thrombosis, and vascular biology"More Details
    18276907 A potential role of the CXC chemokine GROalpha in atherosclerosis and plaque destabilization: downregulatory effects of statins."Arteriosclerosis, thrombosis, and vascular biology"More Details
    16456237 Altered chemokine receptor profile on circulating leukocytes in human heart failure.Cell biochemistry and biophysicsMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 23 unique genes interacted with CXCR2. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    RAB11FIP2 Affinity Capture-Western15004234 No
    MYO5B Affinity Capture-Western15004234|15004234 No
    CXCR2 Affinity Capture-Western12888558|12888558 CHD related
    GTF3A Affinity Capture-Western11170396 No
    ARRB1 Affinity Capture-Western11170396|11170396 No
    IL8 Reconstituted Complex9464567 CHD related
    ST13 Two-hybrid11751889|11751889|11751889|11751889 No
    CXCR1 in vivo15946947 CHD related
    PPP2CA in vitro;in vivo11278485 CHD related
    GNA14 in vivo8316840 No
    GNAI3 in vivo8316840 No
    GRIA1 in vivo12888558 No
    CXCL6 in vivo10593335,9692902 No
    CXCL2 in vitro;in vivo8702798,9260277 CHD related
    CXCL3 in vivo8702798 No
    GNA15 in vivo9843397 No
    Rgs12 Far Western9651375 No
    ADRA1A in vivo15946947 CHD related
    GNAI2 in vivo8662698 No
    GPRASP1 in vitro15452121 No
    CXCL1 in vivo8550564,8940121,8702798,1379593 CHD related
    PPBP in vivo8702798,8195702 No
    CXCL5 in vivo9692902,8702798 CHD related


    Involved FDA drugs

    There was no drug associated with CXCR2