How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
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    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: CXCR3

    Description: chemokine (C-X-C motif) receptor 3

    Entrez Gene ID: 2833

    SwissProt Acc Number: P49682

    RefSeq: NM_001142797

    It was suspected to be CHD related:

    ..Patients with CAD had a higher percentage of constitutive CCR2(+) and CXCR3(+) cells after stimulation with oxLDL..

    From PMID: 18617279, in Journal Int J Cardiol , 2009


    There were 10 potential papers with CXCR3 and CHD.

    22262158 Early alterations of the immune transcriptome in cultured progenitor cells from obese African-American women."Obesity (Silver Spring, Md.)"More Details
    18617279 "Differential expression of cytokines, chemokines and chemokine receptors in patients with coronary artery disease."International journal of cardiologyMore Details
    19421322 Atorvastatin reduces plasma levels of chemokine (CXCL10) in patients with Crohn's disease.PloS oneMore Details
    17363708 Interferon-gamma axis in graft arteriosclerosis.Circulation researchMore Details
    16940188 "Heparin displaces interferon-gamma-inducible chemokines (IP-10, I-TAC, and Mig) sequestered in the vasculature and inhibits the transendothelial migration and arterial recruitment of T cells."CirculationMore Details
    17015796 The chemokine and chemokine receptor profile of infiltrating cells in the wall of arteries with cardiac allograft vasculopathy is indicative of a memory T-helper 1 response.CirculationMore Details
    16682613 Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells.CirculationMore Details
    16456237 Altered chemokine receptor profile on circulating leukocytes in human heart failure.Cell biochemistry and biophysicsMore Details
    15135807 Increased Th1 activity in patients with coronary artery disease.CytokineMore Details
    12695288 Elevated serum levels of the CXCR3 chemokine ITAC are associated with the development of transplant coronary artery disease.CirculationMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 7 unique genes interacted with CXCR3. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    CXCL10 Reconstituted Complex12782716|12571234,10233762 CHD related
    PF4 Reconstituted Complex12782716|12782716 CHD related
    CXCL9 Reconstituted Complex12782716|9660793 CHD related
    CXCL11 Reconstituted Complex12782716 CHD related
    CXCL13 Reconstituted Complex11554781 No
    CXCR3 in vitro11739530,12782716 CHD related
    VCAN Reconstituted Complex11083865 CHD related

    Involved FDA drugs

    There was no drug associated with CXCR3