How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: CYBA

    Description: "cytochrome b-245, alpha polypeptide"

    Entrez Gene ID: 1535

    SwissProt Acc Number: P13498

    RefSeq: NM_000101

    It was suspected to be CHD related:

    ..The CYBA gene A640G polymorphism influences predispositions to coronary artery disease through interactions with cigarette smoking and hypercholesterolemia...

    From PMID: 21777168, in Journal Biomarkers. , 2011


    References

    There were 14 potential papers with CYBA and CHD.

    PMIDTitleJournalsDetails
    24039708 Relationship of the p22phox (CYBA) gene polymorphism C242T with risk of coronary artery disease: a meta-analysis.PloS oneMore Details
    22268370 CYBA C242T polymorphism is associated with obesity and diabetes mellitus in Brazilian hypertensive patients.Diabetic medicine : a journal of the British Diabetic AssociationMore Details
    22199011 Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies.Circulation. Cardiovascular geneticsMore Details
    21136016 The effect of p22-PHOX (CYBA) polymorphisms on premature coronary artery disease (</= 40 years of age).Thrombosis and haemostasisMore Details
    21130994 Strong association of the APOA5-1131T>C gene variant and early-onset acute myocardial infarction.AtherosclerosisMore Details
    22011848 Thrombospondin-4 polymorphism (A387P) predicts cardiovascular risk in postinfarction patients with high HDL cholesterol and C-reactive protein levels.Thrombosis and haemostasisMore Details
    21777168 The CYBA gene A640G polymorphism influences predispositions to coronary artery disease through interactions with cigarette smoking and hypercholesterolemia."Biomarkers : biochemical indicators of exposure, response, and susceptibility to "More Details
    20512451 "Association of the CYBA, PPARGC1A, PPARG3, and PPARD gene variants with coronary artery disease and metabolic risk factors of coronary atherosclerosis in a Russian population."Heart and vesselsMore Details
    20603655 CYBA gene variants as biomarkers for coronary artery disease.Drug news & perspectivesMore Details
    18398337 Vascular stiffness is related to superoxide generation in the vessel wall.Journal of hypertensionMore Details
    18324526 Insight into the role of CYBA A640G and C242T gene variants and coronary heart disease risk. A case-control study.Free radical researchMore Details
    17627182 The 242T variant of the CYBA gene polymorphism increases the risk of coronary artery disease associated with cigarette smoking and hypercholesterolemia.Coronary artery diseaseMore Details
    15255799 Endothelial venodilator response in carriers of genetic polymorphisms involved in NO synthesis and degradation.British journal of clinical pharmacologyMore Details
    12639216 The C242T p22phox polymorphism and endothelium-dependent vasodilation in subjects with hypercholesterolaemia."Clinical science (London, England : 1979)"More Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 8 unique genes interacted with CYBA. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    VHL Affinity Capture-Western17200123 No
    UBC Affinity Capture-Western17200123 No
    NCF4 in vivo11893732 No
    NCF1 Reconstituted Complex7938008|11893732,7938008,9121467 CHD related
    NCF2 Reconstituted Complex11917128|11733522 No
    RAC1 in vitro10486263 CHD related
    NOX1 in vitro;in vivo15322091 CHD related
    CYBB in vitro;in vivo7938008,11893732 CHD related


    Involved FDA drugs

    There was no drug associated with CYBA