How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: CYP1A1

    Description: "cytochrome P450, family 1, subfamily A, polypeptide 1"

    Entrez Gene ID: 1543

    SwissProt Acc Number: P04798

    RefSeq: NM_000499

    It was suspected to be CHD related:

    ..CYP1A1 MSPI (T6235C) gene polymorphism is associated with mortality in acute coronary syndrome patients...

    From PMID: 19650794, in Journal Clin Exp Pharmacol Physiol. , 2010


    References

    There were 11 potential papers with CYP1A1 and CHD.

    PMIDTitleJournalsDetails
    23906684 Genetic associations with coronary heart disease: meta-analyses of 12 candidate genetic variants.GeneMore Details
    23229202 Lack of association between CYP1A1 T6235C polymorphism and coronary artery disease: evidence from a meta-analysis.Molecular medicine reportsMore Details
    21848428 "Impact of genetic variations of the CYP1A1, GSTT1, and GSTM1 genes on the risk of coronary artery disease."DNA and cell biologyMore Details
    19650794 CYP1A1 MSPI (T6235C) gene polymorphism is associated with mortality in acute coronary syndrome patients.Clinical and experimental pharmacology & physiologyMore Details
    19563927 "Polymorphisms of cytochrome P450 1A1, cigarette smoking and risk of coronary artery disease."Mutation researchMore Details
    18583868 Impact of glutathione S-transferase M1 and T1 gene polymorphisms on the smoking-related coronary artery disease.Journal of Korean medical scienceMore Details
    17408703 "GSTM1, GSTT1 and CYP1A1 detoxification gene polymorphisms and susceptibility to smoking-related coronary artery disease: a case-only study."Mutation researchMore Details
    17955387 PPARalpha ligands reduce PCB-induced endothelial activation: possible interactions in inflammation and atherosclerosis.Cardiovascular toxicologyMore Details
    15696395 Smoking-gene interaction and disease development: relevance to pancreatic cancer and atherosclerosis.World journal of surgeryMore Details
    15466009 Genetic polymorphism of CYP1A2 increases the risk of myocardial infarction.Journal of medical geneticsMore Details
    12704594 Genetic influence on cigarette-induced cardiovascular disease.Progress in cardiovascular diseasesMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 1 unique genes interacted with CYP1A1. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    CYB5A in vitro6102994 No


    Involved FDA drugs

    There was no drug associated with CYP1A1