How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
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    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: CYP1A2

    Description: "cytochrome P450, family 1, subfamily A, polypeptide 2"

    Entrez Gene ID: 1544

    SwissProt Acc Number: P05177

    RefSeq: NM_000761

    It was supported literatures to be a novel CHD related gene:

    ..The low inducibility genotype for CYP1A2 was associated with an increased risk of MI...

    From PMID: 15466009, in Journal J Med Genet. , 2004


    There were 6 potential papers with CYP1A2 and CHD.

    24262617 Routine assessment of on-clopidogrel platelet reactivity and gene polymorphisms in predicting clinical outcome following drug-eluting stent implantation in patients with stable coronary artery disease.JACC. Cardiovascular interventionsMore Details
    22079696 "Evaluation of impact of Herba Erigerontis injection, a Chinese herbal prescription, on rat hepatic cytochrome P450 enzymes by cocktail probe drugs."Journal of ethnopharmacologyMore Details
    21095272 "Association between smoking, outcomes, and early clopidogrel use in patients with acute coronary syndrome: insights from the Global Registry of Acute Coronary Events."American heart journalMore Details
    20093140 Effect of cytochrome P450 polymorphism on arachidonic acid metabolism and their impact on cardiovascular diseases.Pharmacology & therapeuticsMore Details
    17961194 Effect of danshen extract on pharmacokinetics of theophylline in healthy volunteers.British journal of clinical pharmacologyMore Details
    15466009 Genetic polymorphism of CYP1A2 increases the risk of myocardial infarction.Journal of medical geneticsMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 1 unique genes interacted with CYP1A2. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    POR Reconstituted Complex9398194 No

    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code