How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: CYP2E1

    Description: "cytochrome P450, family 2, subfamily E, polypeptide 1"

    Entrez Gene ID: 1571

    SwissProt Acc Number: P05181

    RefSeq: NM_000773

    It was suspected to be CHD related:

    ..A significantly higher frequency of CYP2E1 (*C2 (+Pst I)) allele has been revealed in the CA group (P = 0.043; OR = 4.23; 95% CI 1.03-20.01)...

    From PMID: 17486761, in Journal Genetika. , 2007


    References

    There were 3 potential papers with CYP2E1 and CHD.

    PMIDTitleJournalsDetails
    22079696 "Evaluation of impact of Herba Erigerontis injection, a Chinese herbal prescription, on rat hepatic cytochrome P450 enzymes by cocktail probe drugs."Journal of ethnopharmacologyMore Details
    20093049 DNA repair gene polymorphism is associated with the genetic basis of atherosclerotic coronary artery disease.Cardiovascular pathology : the official journal of the Society for CardiovascularMore Details
    20406102 Cytochrome P4502E1 (CYP2E1) genetic polymorphisms in a Lebanese population: frequency distribution and association with morbid diseases.Genetic testing and molecular biomarkersMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 6 unique genes interacted with CYP2E1. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    UBC Affinity Capture-Western16331994 No
    FANCG Two-hybrid14499622|11756225 No
    POR Reconstituted Complex9398194 No
    STUB1 Biochemical Activity21209460 No
    AMFR Biochemical Activity21209460 No
    DYT10 Biochemical Activity21209460 No


    Involved FDA drugs

    There was no drug associated with CYP2E1