How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: CYP2J2

    Description: "cytochrome P450, family 2, subfamily J, polypeptide 2"

    Entrez Gene ID: 1573

    SwissProt Acc Number: P51589

    RefSeq: NM_000775

    It was suspected to be CHD related:

    .."The G-50T polymorphism in CYP2J2 may be an important risk factor for the development of coronary heart disease events in African-Americans, whereas cigarette smoking may modify the relationship between the I264M and K399R polymorphisms in CYP2C8 and coronary heart disease risk in Caucasians."..

    From PMID: 17429317, in Journal Pharmacogenet Genomics.? , 2007


    References

    There were 11 potential papers with CYP2J2 and CHD.

    PMIDTitleJournalsDetails
    24148690 "The role of 14,15-dihydroxyeicosatrienoic acid levels in inflammation and its relationship to lipoproteins."Lipids in health and diseaseMore Details
    23647230 Structural basis for the mutation-induced dysfunction of human CYP2J2: a computational study.Journal of chemical information and modelingMore Details
    23684773 A novel polymorphism of the CYP2J2 gene is associated with coronary artery disease in Uygur population in China.Clinical biochemistryMore Details
    23041291 Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice.Prostaglandins & other lipid mediatorsMore Details
    21642892 Association between polymorphisms of CYP2J2 and EPHX2 genes and risk of coronary artery disease.Pharmacogenetics and genomicsMore Details
    20093140 Effect of cytochrome P450 polymorphism on arachidonic acid metabolism and their impact on cardiovascular diseases.Pharmacology & therapeuticsMore Details
    19105833 The CYP2J2 G-50T polymorphism and myocardial infarction in patients with cardiovascular risk profile.BMC cardiovascular disordersMore Details
    17429317 CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study.Pharmacogenetics and genomicsMore Details
    17164128 Cyclic AMP-dependent modulation of cardiac L-type Ca2+ and transient outward K+ channel activities by epoxyeicosatrienoic acids.Prostaglandins & other lipid mediatorsMore Details
    16839864 Cytochrome P450 epoxygenase CYP2J2 and the risk of coronary artery disease.Trends in cardiovascular medicineMore Details
    15466638 Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2.CirculationMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There was NO PPI interaction information about CYP2J2



    Involved FDA drugs

    There was no drug associated with CYP2J2