How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: CYP4A11

    Description: "cytochrome P450, family 4, subfamily A, polypeptide 11"

    Entrez Gene ID: 1579

    SwissProt Acc Number: Q02928

    RefSeq: NM_000778

    It was suspected to be CHD related:

    ..In patients with established and stable coronary artery disease the 434SS variant of CYP4A11 F434 is associated with pronounced coronary vasoconstriction...

    From PMID: 19615687, in Journal Atherosclerosis , 2009


    References

    There were 5 potential papers with CYP4A11 and CHD.

    PMIDTitleJournalsDetails
    22327816 A novel polymorphism of the CYP4A11 gene is associated with coronary artery disease.Clinical and applied thrombosis/hemostasis : official journal of theMore Details
    23085321 Haplotype study of the CYP4A11 gene and coronary artery disease in Han and Uygur populations in China.GeneMore Details
    20093140 Effect of cytochrome P450 polymorphism on arachidonic acid metabolism and their impact on cardiovascular diseases.Pharmacology & therapeuticsMore Details
    19615687 CYP4A11 polymorphism correlates with coronary endothelial dysfunction in patients with coronary artery disease--the ENCORE Trials.AtherosclerosisMore Details
    18574070 The V433M variant of the CYP4F2 is associated with ischemic stroke in male Swedes beyond its effect on blood pressure.HypertensionMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 1 unique genes interacted with CYP4A11. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    PIK3R1 Two-hybrid18624398 CHD related


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approved;nutraceuticalDB00157NADH"Some evidence suggests that NADH might be useful in treating Parkinson's disease, chronic fatigue syndrome, Alzheimer's disease and cardiovascular disease."