How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: CYP7A1

    Description: "cytochrome P450, family 7, subfamily A, polypeptide 1"

    Entrez Gene ID: 1581

    SwissProt Acc Number: P22680

    RefSeq: NM_000780

    It was supported literatures to be a novel CHD related gene:

    .."Other gene regions that influence plasma lipid and apolipoprotein levels within race include CYP7A1, LPL, PPARA, SOAT1, and SREBF2."..

    From PMID: 16763159, in Journal Arterioscler Thromb Vasc Biol. , 2006


    References

    There were 15 potential papers with CYP7A1 and CHD.

    PMIDTitleJournalsDetails
    24049113 "Mg supplementation attenuates ritonavir-induced hyperlipidemia, oxidative stress, and cardiac dysfunction in rats.""American journal of physiology. Regulatory, integrative and comparative"More Details
    22648615 The effect of taurine on cholesterol metabolism.Molecular nutrition & food researchMore Details
    22494195 Hypolipidemic effects of a new piperine derivative GB-N from Piper longum in high-fat diet-fed rats.Pharmaceutical biologyMore Details
    21858147 Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease.PloS oneMore Details
    20578904 "Common variants of HMGCR, CETP, APOAI, ABCB1, CYP3A4, and CYP7A1 genes as predictors of lipid-lowering response to atorvastatin therapy."DNA and cell biologyMore Details
    20686565 "Biological, clinical and population relevance of 95 loci for blood lipids."NatureMore Details
    19558216 A combination of proatherogenic single-nucleotide polymorphisms is associated with increased risk of coronary artery disease and myocardial infarction in Asian Indians.DNA and cell biologyMore Details
    18633604 Cytochrome P450 and gene activation--from pharmacology to cholesterol elimination and regression of atherosclerosis.European journal of clinical pharmacologyMore Details
    16439690 Elevated homocysteine reduces apolipoprotein A-I expression in hyperhomocysteinemic mice and in males with coronary artery disease.Circulation researchMore Details
    16763159 Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants."Arteriosclerosis, thrombosis, and vascular biology"More Details
    15707388 Genetic variation in the rate-limiting enzyme in cholesterol catabolism (cholesterol 7alpha-hydroxylase) influences the progression of atherosclerosis and risk of new clinical events."Clinical science (London, England : 1979)"More Details
    15530894 Pharmacogenetics of HMG-CoA reductase inhibitors: exploring the potential for genotype-based individualization of coronary heart disease management.AtherosclerosisMore Details
    15030301 Primary hypercholesterolemia: genetic causes and treatment of five monogenic disorders.Expert review of cardiovascular therapyMore Details
    12475897 Pharmacological interference with intestinal bile acid transport reduces plasma cholesterol in LDL receptor/apoE deficiency.FASEB journal : official publication of the Federation of American Societies for More Details
    12093894 Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype.The Journal of clinical investigationMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There was NO PPI interaction information about CYP7A1



    Involved FDA drugs

    There was no drug associated with CYP7A1