How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: EGFR

    Description: "epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)"

    Entrez Gene ID: 1956

    SwissProt Acc Number: P00533

    RefSeq: NM_005228

    It was suspected to be CHD related:

    ..Diabetes and microvascular pathophysiology: role of epidermal growth factor receptor tyrosine kinase...

    From PMID: 19943320, in Journal Diabetes?Metab Res Rev. , 2010


    References

    There were 331 potential papers with EGFR and CHD.

    PMIDTitleJournalsDetails
    23218582 Renal dysfunction and long-term risk of ischemic and hemorrhagic stroke following coronary artery bypass grafting.International journal of cardiologyMore Details
    24174963 The efficacy of the cystatin C based glomerular filtration rate in the estimation of safe contrast media volume.Korean circulation journalMore Details
    23731921 "Relation of estimated glomerular filtration rate and body mass index to mortality in non-dialysis patients with coronary artery disease: a report from the ET-CHD registry, 1997-2003."Journal of cardiologyMore Details
    23698074 Cystatin C- and creatinine-based estimates of renal function and their value for risk prediction in patients with acute coronary syndrome: results from the PLATelet Inhibition and Patient Outcomes (PLATO) study.Clinical chemistryMore Details
    23835686 Impaired renal function further increases odds of 6-year coronary artery calcification progression in adults with type 1 diabetes: the CACTI study.Diabetes careMore Details
    23845772 Patients with severe chronic kidney disease benefit from early revascularization after acute coronary syndrome.International journal of cardiologyMore Details
    23880581 Cardiovascular medication in relation to renal function after coronary artery bypass surgery.International journal of cardiologyMore Details
    24101712 Comparison of Cockcroft-Gault and Modification of Diet in Renal Disease Formulas as Predictors of Cardiovascular Outcomes in Patients With Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention.AngiologyMore Details
    24178969 Change in Albuminuria and eGFR Following Insulin Sensitization Therapy Versus Insulin Provision Therapy in the BARI 2D Study.Clinical journal of the American Society of Nephrology : CJASNMore Details
    24177327 Role of Soluble Endothelial Cell-Selective Adhesion Molecule Biomarker in Albuminuria and Kidney Function Changes in Patients With Coronary Artery Disease."Arteriosclerosis, thrombosis, and vascular biology"More Details
    23453439 Long-term benefits and risks of drug-eluting compared to bare-metal stents in patients with versus without chronic kidney disease.International journal of cardiologyMore Details
    23643437 Cardiovascular readmissions and excess costs following percutaneous coronary intervention in patients with chronic kidney disease: data from a large multi-centre Australian registry.International journal of cardiologyMore Details
    23415169 Vitamin D and prognosis in acute myocardial infarction.International journal of cardiologyMore Details
    24158986 Fibroblast Growth Factor-23 and Cardiovascular Events in CKD.Journal of the American Society of Nephrology : JASNMore Details
    24169005 Usefulness of Serial Decline of Kidney Function to Predict Mortality and Cardiovascular Events in Patients Undergoing Coronary Angiography.The American journal of cardiologyMore Details
    23816477 Pravastatin and cardiovascular outcomes stratified by baseline eGFR in the lipid- lowering component of ALLHAT.Clinical nephrologyMore Details
    23773369 Drug-eluting stents versus bare-metal stents in patients with decreased GFR: a meta-analysis.American journal of kidney diseases : the official journal of the National KidneyMore Details
    23769137 "CKD and cardiovascular disease in the Atherosclerosis Risk in Communities (ARIC) study: interactions with age, sex, and race."American journal of kidney diseases : the official journal of the National KidneyMore Details
    24198448 Association between nonalcoholic fatty liver disease and the incidence of cardiovascular and renal events.Journal of the Saudi Heart AssociationMore Details
    23712332 Impaired renal function is a major determinant of left ventricular diastolic dysfunction: assessment by stress myocardial perfusion imaging.Annals of nuclear medicineMore Details
    23425679 Impact of increasing degrees of renal impairment on outcomes of coronary artery bypass grafting: the off-pump advantage.European journal of cardio-thoracic surgery : official journal of the EuropeanMore Details
    24285128 Renal function after percutaneous coronary interventions depending on the type of hydration.Advances in medical sciencesMore Details
    24271191 "Cystatin C- and creatinine-based estimated glomerular filtration rate, vascular disease, and mortality in persons with diabetes in the United States."Diabetes careMore Details
    24235082 The inflammation-lipocalin 2 axis may contribute to the development of chronic kidney disease."Nephrology, dialysis, transplantation : official publication of the European"More Details
    24189004 Risk Factors Associated with the Diagnosis of Abdominal Aortic Aneurysm in Patients Screened at a Regional Veterans Affairs Health Care System.Annals of vascular surgeryMore Details
    23975142 beta-Trace Protein and Prognosis in Patients With Atrial Fibrillation Receiving Anticoagulation Treatment.ChestMore Details
    23317678 Impact of estimated glomerular filtration rate on vascular disease extent and adverse cardiovascular events in patients without chronic kidney disease.The Canadian journal of cardiologyMore Details
    22790660 Association of Circulating Endothelial Progenitor Cells (CD14+-EPC) With Renal Function in Patients With Coronary Artery Disease.Clinical and applied thrombosis/hemostasis : official journal of theMore Details
    24265524 Decreased renal function is an independent predictor of severity of coronary artery disease: an application of gensini score.Journal of Korean medical scienceMore Details
    23688069 Chronic kidney disease is associated with adverse outcomes among elderly patients taking clopidogrel after hospitalization for acute coronary syndrome.BMC nephrologyMore Details
    23636853 Glomerular Filtration Rate is Associated With Burden of Coronary Atherosclerosis in Patients With Acute Coronary Syndrome.AngiologyMore Details
    23622918 Comparative effectiveness of coronary artery bypass grafting and percutaneous coronary intervention for multivessel coronary disease in a community-based population with chronic kidney disease.American heart journalMore Details
    23687359 Association between LDL-C and risk of myocardial infarction in CKD.Journal of the American Society of Nephrology : JASNMore Details
    23172583 Predictors of coronary lesions complexity in patients with stable coronary artery disease.AngiologyMore Details
    23614851 Contribution of glomerular filtration rate to 10-year cardiovascular and mortality risk among hypertensive adults: Tehran lipid and glucose study."Journal of clinical hypertension (Greenwich, Conn.)"More Details
    23507123 Outcome of elective total aortic arch replacement in patients with non-dialysis-dependent renal insufficiency stratified by estimated glomerular filtration rate.The Journal of thoracic and cardiovascular surgeryMore Details
    22457095 Characterization of the effect of serum bilirubin concentrations on coronary endothelial function via measurement of high-sensitivity C-reactive protein and high-density lipoprotein cholesterol.Heart and vesselsMore Details
    23303394 Hypertensive target organ damage and the risk for vascular events and all-cause mortality in patients with vascular disease.Journal of hypertensionMore Details
    23772896 Mean platelet volume is independently associated with renal dysfunction in stable coronary artery disease.PlateletsMore Details
    22023803 The prognostic role of chronic obstructive pulmonary disease in ST-elevation myocardial infarction after primary angioplasty.European journal of preventive cardiologyMore Details
    23314596 Serum surfactant protein D is associated with the prognosis in patients with chronic kidney disease."Journal of cardiovascular medicine (Hagerstown, Md.)"More Details
    23585585 Contrast-induced acute kidney injury following coronary angiography: a cohort study of hospitalized patients with or without chronic kidney disease."Nephrology, dialysis, transplantation : official publication of the European"More Details
    22244477 Impact of elevated serum glycated albumin levels on contrast-induced acute kidney injury in diabetic patients with moderate to severe renal insufficiency undergoing coronary angiography.International journal of cardiologyMore Details
    23752917 "Prediction of cardiovascular disease mortality by proteinuria and reduced kidney function: pooled analysis of 39,000 individuals from 7 cohort studies in Japan."American journal of epidemiologyMore Details
    23816033 Renal dysfunction and long-term risk of heart failure after coronary artery bypass grafting.American heart journalMore Details
    23714334 "Renal function and short-term outcome in stable outpatients with coronary, cerebrovascular or peripheral artery disease."AtherosclerosisMore Details
    23143668 Impact of renal function on clopidogrel-induced antiplatelet effects in coronary artery disease patients without diabetes mellitus.Journal of thrombosis and thrombolysisMore Details
    23442255 Effect of rosuvastatin and sevelamer on the progression of coronary artery calcification in chronic kidney disease: a pilot study.Clinical nephrologyMore Details
    23579986 Different value of coronary calcium score to predict obstructive coronary artery disease in patients with and without moderate chronic kidney disease.Netherlands heart journal : monthly journal of the Netherlands Society ofMore Details
    23541630 Examining renal impairment as a risk factor for acute coronary syndrome: a prospective observational study.Annals of emergency medicineMore Details
    22460182 "Associations among chronic kidney disease, high total p-cresylsulfate and major adverse cardiac events."Journal of nephrologyMore Details
    23358876 Accelerated decline in renal function after acute myocardial infarction in patients with high low-density lipoprotein-cholesterol to high-density lipoprotein-cholesterol ratio.Heart and vesselsMore Details
    23335655 Target organ damage and cardiovascular risk factors among subjects with previously undiagnosed hypertension.European journal of preventive cardiologyMore Details
    23094818 Medical outcomes in African American live kidney donors: a matched cohort study.American journal of transplantation : official journal of the American Society ofMore Details
    23137826 A preliminary study of the potential role of FGF-23 in coronary calcification in patients with suspected coronary artery disease.AtherosclerosisMore Details
    22542819 "Body mass index, coronary artery calcification, and kidney function decline in stage 3 to 5 chronic kidney disease patients."Journal of renal nutrition : the official journal of the Council on RenalMore Details
    23382541 Estimated glomerular filtration rate in a population with normal to mildly reduced renal function as predictor of cardiovascular disease.European journal of preventive cardiologyMore Details
    24304491 Neutrophil gelatinase-associated lipocalin (NGAL) for the early detection of contrast-induced nephropathy after percutaneous coronary intervention.Scandinavian journal of clinical and laboratory investigationMore Details
    24305547 Urinary Neutrophil Gelatinase-Associated Lipocalin predicts the severity of contrast-induced acute kidney injury in chronic kidney disease patients undergoing elective coronary procedures.BMC nephrologyMore Details
    24194563 The impact of age and chronic kidney disease on secondary prevention post-primary percutaneous coronary intervention.QJM : monthly journal of the Association of PhysiciansMore Details
    24142755 Aspirin resistance in patients with impaired renal functions.Kardiologia polskaMore Details
    24001741 Prediction of cardiovascular events in pre-dialysis chronic kidney disease patients with normal SPECT myocardial perfusion imaging.Journal of cardiologyMore Details
    23949089 Preoperative estimated glomerular filtration rate as a significant predictor of long-term outcomes after coronary artery bypass grafting in Japanese patients.General thoracic and cardiovascular surgeryMore Details
    23937620 Impaired renal function impacts negatively on vascular stiffness in patients with coronary artery disease.BMC nephrologyMore Details
    22349044 The prognostic impact of in-hospital worsening of renal function in patients with acute coronary syndrome.International journal of cardiologyMore Details
    23706287 Cystatin C is independently associated with total and cardiovascular mortality in individuals undergoing coronary angiography. The Ludwigshafen Risk and Cardiovascular Health (LURIC) study.AtherosclerosisMore Details
    23552516 Significance of estimating the glomerular filtration rate for the management of hypertension in type 2 diabetes with microalbuminuria.Hypertension research : official journal of the Japanese Society of HypertensionMore Details
    23594677 Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in elders: results from the Hisayama Study.Kidney internationalMore Details
    21611779 Prevalence of renal artery stenosis in patients undergoing cardiac catheterization.Internal and emergency medicineMore Details
    23552901 Impact of aging on the clinical outcomes of Japanese patients with coronary artery disease after percutaneous coronary intervention.Heart and vesselsMore Details
    23548034 Impact of non-dialysis chronic kidney disease on survival in patients with septic shock.BMC nephrologyMore Details
    23922934 "Progression of kidney disease in non-diabetic patients with coronary artery disease: predictive role of circulating matrix metalloproteinase-2, -3, and -9."PloS oneMore Details
    23176376 An uninvestigated risk factor for contrast-induced nephropathy in chronic kidney disease: proteinuria.Renal failureMore Details
    23802885 "Evaluation of cardiovascular disease burden and therapeutic goal attainment in US adults with chronic kidney disease: an analysis of national health and nutritional examination survey data, 2001-2010."BMC nephrologyMore Details
    23953602 Circulating concentrations of GLP-1 are associated with coronary atherosclerosis in humans.Cardiovascular diabetologyMore Details
    23506004 Renal dysfunction in STEMI-patients undergoing primary angioplasty: higher prevalence but equal prognostic impact in female patients; an observational cohort study from the Belgian STEMI registry.BMC nephrologyMore Details
    23547730 Serum pigment epithelium-derived factor levels are independently correlated with the presence of coronary artery disease.Cardiovascular diabetologyMore Details
    23838572 Renal dysfunction and atherosclerosis of the neointima following bare metal stent implantation.American journal of nephrologyMore Details
    23594619 Glomerular filtration rate and albuminuria predict mortality independently from coronary artery calcified plaque in the Diabetes Heart Study.Cardiovascular diabetologyMore Details
    24198444 Urinary leukotriene E4 is associated with renal function but not with endothelial function in type 2 diabetes.Disease markersMore Details
    24008871 Relation of estimated glomerular filtration rate to the presence of coronary plaque and obstructive coronary artery disease in a zero or low coronary artery calcium score.CardiologyMore Details
    22419375 Chronic kidney disease and the risk of stent thrombosis after percutaneous coronary intervention with drug-eluting stents.Catheterization and cardiovascular interventions : official journal of theMore Details
    22717317 Risk of coronary events in people with chronic kidney disease compared with those with diabetes: a population-level cohort study.LancetMore Details
    22708952 Impacts of estimated glomerular filtration rate on coronary atherosclerosis and plaque composition before and during statin therapy in patients with normal to mild renal dysfunction: subanalysis of the TRUTH study."Nephrology (Carlton, Vic.)"More Details
    22459775 The relationship between pulmonary emphysema and kidney function in smokers.ChestMore Details
    22554422 An integrated biochemical prediction model of all-cause mortality in patients undergoing lower extremity bypass surgery for advanced peripheral artery disease.Journal of vascular surgeryMore Details
    22791885 Interpreting cardiac troponin results from high-sensitivity assays in chronic kidney disease without acute coronary syndrome.Clinical chemistryMore Details
    22728005 Effect of late revascularization of a totally occluded coronary artery after myocardial infarction on mortality rates in patients with renal impairment.The American journal of cardiologyMore Details
    23195672 Renal impairment is associated with coronary heart disease in HIV-positive men.HIV clinical trialsMore Details
    23045301 Renal tolerability of iopromide and iodixanol in 562 renally impaired patients undergoing cardiac catheterisation: the DIRECT study.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on More Details
    22883164 Kidney function and progression of coronary artery calcium in community-dwelling older adults (from the Rancho Bernardo Study).The American journal of cardiologyMore Details
    22841159 Estimated GFR and incident cardiovascular disease events in American Indians: the Strong Heart Study.American journal of kidney diseases : the official journal of the National KidneyMore Details
    21928225 Elevated serum cystatin C is an independent predictor of cardiovascular events in people with relatively normal renal function.Journal of nephrologyMore Details
    22428529 Impact of impaired renal function and metabolic syndrome on the recurrence of atrial fibrillation after catheter ablation: a long term follow-up.Pacing and clinical electrophysiology : PACEMore Details
    21748719 "Association of chronic kidney disease and coronary artery disease in 1,010 consecutive patients undergoing coronary angiography."Journal of nephrologyMore Details
    21771758 Impact of chronic kidney disease on the incidence of peri-procedural myocardial injury in patients undergoing elective stent implantation."Nephrology, dialysis, transplantation : official publication of the European"More Details
    22335251 Prevalence and risk factors for chronic kidney disease in patients with coronary artery disease.Current medical research and opinionMore Details
    22072111 Eosinophil count is positively correlated with coronary artery calcification.Hypertension research : official journal of the Japanese Society of HypertensionMore Details
    22490878 Long-term renal and cardiovascular outcomes in Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) participants by baseline estimated GFR.Clinical journal of the American Society of Nephrology : CJASNMore Details
    22573072 Cardiovascular risk assessment beyond Systemic Coronary Risk Estimation: a role for organ damage markers.Journal of hypertensionMore Details
    22445708 GFR and cardiovascular outcomes after acute myocardial infarction: results from the Korea Acute Myocardial Infarction Registry.American journal of kidney diseases : the official journal of the National KidneyMore Details
    22562499 Impaired global myocardial flow dynamics despite normal left ventricular function and regional perfusion in chronic kidney disease: a quantitative analysis of clinical 82Rb PET/CT studies."Journal of nuclear medicine : official publication, Society of Nuclear Medicine"More Details
    22665332 The relationship between coronary artery calcification and renal function in nondialyzed patients.Yonsei medical journalMore Details
    21735205 Impact of hypertension on short- and long-term prognoses in patients with ST elevation myocardial infarction and without previously known diabetes.Heart and vesselsMore Details
    22093591 "The evaluation of creatinine clearance, estimated glomerular filtration rate and serum creatinine in predicting contrast-induced acute kidney injury among patients undergoing percutaneous coronary intervention."Cardiovascular revascularization medicine : including molecular interventionsMore Details
    22076879 Racial differences in the incidence of chronic kidney disease.Clinical journal of the American Society of Nephrology : CJASNMore Details
    22126936 Cystatin C and estimated glomerular filtration rate as predictors for adverse outcome in patients with ST-elevation and non-ST-elevation acute coronary syndromes: results from the Platelet Inhibition and Patient Outcomes study.Clinical chemistryMore Details
    21709534 Association between peripheral vascular disease indexes and the numbers of vessels obstructed in patients with coronary artery disease.The American journal of the medical sciencesMore Details
    22124714 Diverging association of reduced glomerular filtration rate and albuminuria with coronary and noncoronary events in patients with type 2 diabetes: the renal insufficiency and cardiovascular events (RIACE) Italian multicenter study.Diabetes careMore Details
    21880649 Mild chronic kidney disease is an independent predictor of long-term mortality after emergency angiography and primary percutaneous intervention in patients with ST-elevation myocardial infarction.Heart (British Cardiac Society)More Details
    22305847 "Associations of pentraxin-3 with cardiovascular events, incident heart failure, and mortality among persons with coronary heart disease: data from the Heart and Soul Study."American heart journalMore Details
    22277138 "Uric acid, hypertension, and chronic kidney disease among Alaska Eskimos: the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study.""Journal of clinical hypertension (Greenwich, Conn.)"More Details
    22210576 Benefits and safety of long-term fenofibrate therapy in people with type 2 diabetes and renal impairment: the FIELD Study.Diabetes careMore Details
    21602255 Glomerular filtration rate estimated by the CKD-EPI formula is a powerful predictor of in-hospital adverse clinical outcomes after an acute coronary syndrome.AngiologyMore Details
    22935527 Renal function and effect of statin therapy on cardiovascular outcomes in patients undergoing coronary revascularization (from the CREDO-Kyoto PCI/CABG Registry Cohort-2).The American journal of cardiologyMore Details
    23137952 Sex differences in hypertension-related renal and cardiovascular diseases in Italy: the I-DEMAND study.Journal of hypertensionMore Details
    23063662 Prognostic impact of chronic kidney disease on 10-year clinical outcomes among patients with acute coronary syndrome.Journal of cardiologyMore Details
    22622453 The 9p21 coronary artery disease locus and kidney dysfunction in patients with Type 2 diabetes mellitus."Nephrology, dialysis, transplantation : official publication of the European"More Details
    22857882 Chronic kidney disease predicts poor prognosis in patients with stable premature coronary artery disease.European journal of internal medicineMore Details
    22130958 Association of serum calcitonin with coronary artery disease in individuals with and without chronic kidney disease.International urology and nephrologyMore Details
    22843184 Renal insufficiency is an independent predictor of in-hospital mortality for patients with acute myocardial infarction receiving primary percutaneous coronary intervention.Journal of Zhejiang University. Science. BMore Details
    22245411 Relation between estimated glomerular filtration rate and composition of coronary arterial atherosclerotic plaques.The American journal of cardiologyMore Details
    22369933 The relation of serum gamma-glutamyl transferase levels with coronary lesion complexity and long-term outcome in patients with stable coronary artery disease.AtherosclerosisMore Details
    22147681 Intraaortic balloon pump: incidence and predictors of complications in the Florence registry.Clinical cardiologyMore Details
    22259009 "A randomized, double-blind, placebo-controlled study of the safety and tolerance of regadenoson in subjects with stage 3 or 4 chronic kidney disease."Journal of nuclear cardiology : official publication of the American Society ofMore Details
    22271374 Evaluation of dose requirements for prolonged bivalirudin administration in patients with renal insufficiency and suspected heparin-induced thrombocytopenia.Journal of thrombosis and thrombolysisMore Details
    21839494 Influence of renal function and platelet turnover on the antiplatelet effect of aspirin.Thrombosis researchMore Details
    21450581 Gender-related difference in ST-elevation myocardial infarction treated with primary angioplasty: a single-centre 6-year registry.European journal of preventive cardiologyMore Details
    22423081 Subtle changes in renal function are associated with differences in late survival following adult cardiac surgery.European journal of cardio-thoracic surgery : official journal of the EuropeanMore Details
    23151275 Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study.BMC nephrologyMore Details
    22777315 Classification of chronic kidney disease biomarkers to predict coronary artery calcium.Kidney & blood pressure researchMore Details
    22978689 Cystatin C and asymptomatic coronary artery disease in patients with metabolic syndrome and normal glomerular filtration rate.Cardiovascular diabetologyMore Details
    23071773 Relation between mild to moderate chronic kidney disease and coronary artery disease determined with coronary CT angiography.PloS oneMore Details
    23076940 Antioxidants for chronic kidney disease.The Cochrane database of systematic reviewsMore Details
    22433902 Elevated serum adipocyte fatty acid-binding protein concentrations are independently associated with renal dysfunction in patients with stable angina pectoris.Cardiovascular diabetologyMore Details
    23185262 "Circulating levels of dimethylarginines, chronic kidney disease and long-term clinical outcome in non-ST-elevation myocardial infarction."PloS oneMore Details
    23466572 Painless myocardial ischemia is associated with mortality in patients with chronic kidney disease.Nephron. Clinical practiceMore Details
    22675450 Association of glomerular filtration rate with high-sensitivity cardiac troponin T in a community-based population study in Beijing.PloS oneMore Details
    22792252 Hypoxia changes the expression of the epidermal growth factor (EGF) system in human hearts and cultured cardiomyocytes.PloS oneMore Details
    23056593 High prevalence and associated risk factors for impaired renal function and urinary abnormalities in a rural adult population from southern China.PloS oneMore Details
    22572568 Relationship of urine dopamine with phosphorus homeostasis in humans: the heart and soul study.American journal of nephrologyMore Details
    22514244 Coronary Artery Bypass Grafting Surgery Off- or On-pump Revascularisation Study (CORONARY): kidney substudy analytic protocol of an international randomised controlled trial.BMJ openMore Details
    22880803 Clinical features of Chinese coronary heart disease patients with chronic kidney disease.Renal failureMore Details
    20837369 Effects of high dose aleglitazar on renal function in patients with type 2 diabetes.International journal of cardiologyMore Details
    21300704 Long-term impact of mild chronic kidney disease in patients with acute coronary syndrome undergoing percutaneous coronary interventions."Nephrology, dialysis, transplantation : official publication of the European"More Details
    21783292 Joint association of hyperuricemia and reduced GFR on cardiovascular morbidity: a historical cohort study based on laboratory and claims data from a national insurance provider.American journal of kidney diseases : the official journal of the National KidneyMore Details
    21612781 The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation provides a better definition of cardiovascular burden associated with CKD than the Modification of Diet in Renal Disease (MDRD) Study formula in subjects with type 2 diabetes.AtherosclerosisMore Details
    21958887 Chronic kidney disease and risk for presenting with acute myocardial infarction versus stable exertional angina in adults with coronary heart disease.Journal of the American College of CardiologyMore Details
    21783289 Relationship of estimated GFR and coronary artery calcification in the CRIC (Chronic Renal Insufficiency Cohort) Study.American journal of kidney diseases : the official journal of the National KidneyMore Details
    21887692 Mildly decreased glomerular filtration rate is associated with poor coronary collateral circulation in patients with coronary artery disease.Clinical cardiologyMore Details
    21792599 [New tyrosine kinase and EGFR inhibitors in cancer therapy. Cardiac and skin toxicity as relevant side effects. Part A: heart].Der InternistMore Details
    21782177 Serum cystatin C is associated with early stage coronary atherosclerotic plaque morphology on multidetector computed tomography.AtherosclerosisMore Details
    21791364 The relationship between kidney function and angiographically-derived SYNTAX score.The Canadian journal of cardiologyMore Details
    22078641 Absence of circadian variation of acute coronary syndrome onset in chronic kidney disease patients.Cardiovascular revascularization medicine : including molecular interventionsMore Details
    21378153 Vitamin D status and mortality in chronic kidney disease."Nephrology, dialysis, transplantation : official publication of the European"More Details
    21371709 Renal-related biomarkers and long-term mortality in the US subjects with different coronary risks.AtherosclerosisMore Details
    21455065 Proteinuria and reduced glomerular filtration rate as risk factors for acute kidney injury.Current opinion in nephrology and hypertensionMore Details
    20865265 Poor coronary collateral vessel development in patients with mild to moderate renal insufficiency.Clinical research in cardiology : official journal of the German Cardiac SocietyMore Details
    21338849 Comparison of the CKD Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) study equations: risk factors for and complications of CKD and mortality in the Kidney Early Evaluation Program (KEEP).American journal of kidney diseases : the official journal of the National KidneyMore Details
    21186074 Association of plasma aldosterone with cardiovascular mortality in patients with low estimated GFR: the Ludwigshafen Risk and Cardiovascular Health (LURIC) Study.American journal of kidney diseases : the official journal of the National KidneyMore Details
    20138378 Renal dysfunction and high levels of hsCRP are additively associated with hard endpoints after percutaneous coronary intervention with drug eluting stents.International journal of cardiologyMore Details
    21527648 "Associations among estimated glomerular filtration rate, proteinuria, and adverse cardiovascular outcomes."Clinical journal of the American Society of Nephrology : CJASNMore Details
    21779283 The impact of moderate to severe renal insufficiency on patients with acute myocardial infarction.Korean circulation journalMore Details
    21511839 Chronic kidney disease in octogenarians.Clinical journal of the American Society of Nephrology : CJASNMore Details
    21331740 Risk of macrovascular disease stratified by stage of chronic kidney disease in type 2 diabetic patients: critical level of the estimated glomerular filtration rate and the significance of hyperuricemia.Clinical and experimental nephrologyMore Details
    21655060 Relationship between chronic kidney disease and risk of coronary heart disease in Korean men.Journal of Korean medical scienceMore Details
    23804795 Prevalence of diagnosis and staging of chronic kidney disease by primary care providers in a rural state.Journal of primary care & community healthMore Details
    21642363 Asymmetric dimethylarginine and clinical outcomes in chronic kidney disease.Clinical journal of the American Society of Nephrology : CJASNMore Details
    21549463 High-normal albuminuria and risk of heart failure in the community.American journal of kidney diseases : the official journal of the National KidneyMore Details
    21251579 Cardiovascular mortality in chronic kidney disease patients undergoing percutaneous coronary intervention is mainly related to impaired P2Y12 inhibition by clopidogrel.Journal of the American College of CardiologyMore Details
    20953615 Reduced renal function is associated with combined increases in ventricular-systolic stiffness and arterial load in patients undergoing cardiac catheterization for coronary artery disease.Heart and vesselsMore Details
    21067705 Mechanisms of myogenic tone of coronary arteriole: Role of down stream signaling of the EGFR tyrosine kinase.Microvascular researchMore Details
    20627608 Preoperative prediction of intensive care unit stay following cardiac surgery.European journal of cardio-thoracic surgery : official journal of the EuropeanMore Details
    21257005 Comparison of estimated glomerular filtration rates and albuminuria in predicting risk of coronary heart disease in a population with high prevalence of diabetes mellitus and renal disease.The American journal of cardiologyMore Details
    20930087 Vascular risk factors and cognitive impairment in chronic kidney disease: the Chronic Renal Insufficiency Cohort (CRIC) study.Clinical journal of the American Society of Nephrology : CJASNMore Details
    22328881 IMproving the imPlemEntation of cuRrent guidelines for the mAnagement of major coronary hearT disease rIsk factors by multifactorial interVEntion. The IMPERATIVE renal analysis.Archives of medical science : AMSMore Details
    21704972 Impact of preoperative renal dysfunction in patients undergoing off-pump versus on-pump coronary artery bypass.The Annals of thoracic surgeryMore Details
    21422054 The relationship between chronic kidney disease and SYNTAX score.AngiologyMore Details
    22291802 Markers of kidney function in the elderly in relation to the new CKD-EPI formula for estimation of glomerular filtration rate.Archives of medical science : AMSMore Details
    19945185 Endothelial vasomotor dysfunction in the brachial artery predicts the short-term development of early stage renal dysfunction in patients with coronary artery disease.International journal of cardiologyMore Details
    21393483 Longitudinal association of depressive symptoms with rapid kidney function decline and adverse clinical renal disease outcomes.Clinical journal of the American Society of Nephrology : CJASNMore Details
    21607168 Decreased Glomerular Filtration Rate is an Independent Predictor of In-Hospital Mortality in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.Korean circulation journalMore Details
    20813767 Serum fibroblast growth factor-23 (FGF-23) levels are independently associated with left ventricular mass and myocardial performance index in maintenance haemodialysis patients."Nephrology, dialysis, transplantation : official publication of the European"More Details
    22125626 Hyperuricemia is independently associated with coronary heart disease and renal dysfunction in patients with type 2 diabetes mellitus.PloS oneMore Details
    21389698 Uric acid and pentraxin-3 levels are independently associated with coronary artery disease risk in patients with stage 2 and 3 kidney disease.American journal of nephrologyMore Details
    22056923 A novel model of cardiovascular risk based on kidney function.American journal of nephrologyMore Details
    22258400 Estimated Glomerular Filtration Rate in Short-Risk Stratification in Acute Myocardial Infarction.Cardiorenal medicineMore Details
    21269477 Kidney function and multiple hemostatic markers: cross sectional associations in the multi-ethnic study of atherosclerosis.BMC nephrologyMore Details
    22096561 Decreased glomerular filtration rate is associated with mortality and cardiovascular events in patients with hypertension: a prospective study.PloS oneMore Details
    21917174 Potential role of differential medication use in explaining excess risk of cardiovascular events and death associated with chronic kidney disease: a cohort study.BMC nephrologyMore Details
    21952203 Remote-conditioning ischemia provides a potential approach to mitigate contrast medium-induced reduction in kidney function: a retrospective observational cohort study.CardiologyMore Details
    21977302 Malnutrition as assessed by nutritional risk index is associated with worse outcome in patients admitted with acute decompensated heart failure: an ACAP-HF data analysis.Heart internationalMore Details
    22041637 Timing of coronary angiography and outcome in patients with non-ST elevation acute coronary syndromes and kidney disease: real-world data from the acute coronary syndromes Israeli survey.CardiologyMore Details
    22286241 Association of mild to moderate kidney dysfunction with coronary artery calcification in patients with suspected coronary artery disease.CardiologyMore Details
    21713315 Increased levels of total P-Cresylsulphate and indoxyl sulphate are associated with coronary artery disease in patients with diabetic nephropathy.The review of diabetic studies : RDSMore Details
    20039124 The association of glomerular filtration rate and erectile dysfunction with severity of coronary artery disease in patients presenting with chest pain.International urology and nephrologyMore Details
    20479639 The effect of chronic kidney disease on fibrin clot properties in patients with acute coronary syndrome.Blood coagulation & fibrinolysis : an international journal in haemostasis andMore Details
    20535117 Prevalence and risk factors for renal artery stenosis and chronic kidney disease in Japanese patients with peripheral arterial disease.Hypertension research : official journal of the Japanese Society of HypertensionMore Details
    20796046 Comparison of risk factors for contrast-induced acute kidney injury between patients with and without diabetes.Hemodialysis international. International Symposium on Home HemodialysisMore Details
    20576822 Fibroblast growth factor 23 and fetuin A are independent predictors for the coronary artery disease extent in mild chronic kidney disease.Clinical journal of the American Society of Nephrology : CJASNMore Details
    20334577 Comparison of methods for determination of glomerular filtration rate in hypertensive subjects with normal serum creatinine.Blood pressureMore Details
    20944500 Impact of estimated glomerular filtration rate after valve and combined valve and coronary surgery.ASAIO journal (American Society for Artificial Internal Organs : 1992)More Details
    20692752 "Kidney function, albuminuria, and all-cause mortality in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study."American journal of kidney diseases : the official journal of the National KidneyMore Details
    20706134 Left ventricular hypertrophy as a determinant of renal outcome in patients with high cardiovascular risk.Journal of hypertensionMore Details
    20947866 Impact of contrast-induced nephropathy and cardiovascular events by serum cystatin C in renal insufficiency patients undergoing cardiac catheterization.AngiologyMore Details
    20350524 Estimated glomerular filtration rate is an independent predictor for mortality of patients with acute heart failure.Journal of cardiologyMore Details
    20375690 High prevalence and diversity of kidney dysfunction in patients with type 2 diabetes mellitus and coronary artery disease: the BARI 2D baseline data.The American journal of the medical sciencesMore Details
    19939822 Chronic kidney disease as a predictor of coronary lesion morphology.AngiologyMore Details
    19839780 Renal functional outcomes after cryoablation of small renal masses.Journal of endourology / Endourological SocietyMore Details
    19819453 Plasma cystatin C for prediction of 1-year cardiac events in Mediterranean patients with non-ST elevation acute coronary syndrome.AtherosclerosisMore Details
    19763871 Statins and vitamin D: a friendly association in pre-dialysis patients.International urology and nephrologyMore Details
    20237457 Coronary artery calcification and mortality in diabetic patients with proteinuria.Kidney internationalMore Details
    20438292 B-type natriuretic peptide for prevention of contrast-induced nephropathy in patients with heart failure undergoing primary percutaneous coronary intervention."Acta radiologica (Stockholm, Sweden : 1987)"More Details
    20605853 Augmentation pressure and subendocardial viability ratio are associated with microalbuminuria and with poor renal function in type 1 diabetes.Diabetes & vascular disease research : official journal of the InternationalMore Details
    20359712 Serial decline of kidney function as a novel biomarker for the progression of atherothrombotic disease.AtherosclerosisMore Details
    20633852 Renal function and risk stratification of diabetic and nondiabetic patients undergoing evaluation for coronary artery disease.JACC. Cardiovascular imagingMore Details
    19765871 Association of kidney function with coronary atherosclerosis and calcification in autopsy samples from Japanese elders: the Hisayama study.American journal of kidney diseases : the official journal of the National KidneyMore Details
    19932544 Risk of incident ESRD: a comprehensive look at cardiovascular risk factors and 17 years of follow-up in the Atherosclerosis Risk in Communities (ARIC) Study.American journal of kidney diseases : the official journal of the National KidneyMore Details
    19703834 Impact of renal function on coronary plaque composition."Nephrology, dialysis, transplantation : official publication of the European"More Details
    19943320 Diabetes and microvascular pathophysiology: role of epidermal growth factor receptor tyrosine kinase.Diabetes/metabolism research and reviewsMore Details
    20100969 Association between kidney function and albuminuria with cardiovascular events in HIV-infected persons.CirculationMore Details
    19921505 Lipid and inflammatory biomarkers and kidney function decline in type 2 diabetes.DiabetologiaMore Details
    20498792 Impact of the interval between coronary angiography and off-pump coronary bypass surgery on postoperative renal function.Korean journal of anesthesiologyMore Details
    20184812 The effectiveness and cost-effectiveness of biomarkers for the prioritisation of patients awaiting coronary revascularisation: a systematic review and decision model."Health technology assessment (Winchester, England)"More Details
    19781704 Coronary atherosclerosis detected by coronary CT angiography in asymptomatic subjects with early chronic kidney disease.AtherosclerosisMore Details
    21184562 Diastolic heart failure versus diastolic dysfunction: difference in renal function.Clinical cardiologyMore Details
    21168628 Subclinical left ventricular echocardiographic abnormalities 1 year after kidney transplantation are associated with graft function and future cardiovascular events.Transplantation proceedingsMore Details
    20882027 Association of albuminuria and reduced estimated glomerular filtration rate with incident stroke and coronary artery disease in patients with type 2 diabetes.Hypertension research : official journal of the Japanese Society of HypertensionMore Details
    21181357 "The relationship of cystatin C, creatinine, estimated GFR, and cardiovascular events."Journal of Huazhong University of Science and Technology. Medical sciences = Hua More Details
    20538833 Effect of allopurinol in chronic kidney disease progression and cardiovascular risk.Clinical journal of the American Society of Nephrology : CJASNMore Details
    19729464 Synergistic effects of asymmetrical dimethyl-L-arginine accumulation and endothelial progenitor cell deficiency on renal function decline during a 2-year follow-up in stable angina."Nephrology, dialysis, transplantation : official publication of the European"More Details
    20189275 Risk implications of the new CKD Epidemiology Collaboration (CKD-EPI) equation compared with the MDRD Study equation for estimated GFR: the Atherosclerosis Risk in Communities (ARIC) Study.American journal of kidney diseases : the official journal of the National KidneyMore Details
    19945951 In-hospital outcomes with thrombolytic therapy in patients with renal dysfunction presenting with acute ischaemic stroke."Nephrology, dialysis, transplantation : official publication of the European"More Details
    20024594 Chronic kidney disease management in an academic internal medicine clinic.Clinical and experimental nephrologyMore Details
    20720405 Heritability of renal function and inflammatory markers in adult male twins.American journal of nephrologyMore Details
    21034455 "Plasma concentrations of osteopontin, but not thrombin-cleaved osteopontin, are associated with the presence and severity of nephropathy and coronary artery disease in patients with type 2 diabetes mellitus."Cardiovascular diabetologyMore Details
    20470427 "The estimated GFR, but not the stage of diabetic nephropathy graded by the urinary albumin excretion, is associated with the carotid intima-media thickness in patients with type 2 diabetes mellitus: a cross-sectional study."Cardiovascular diabetologyMore Details
    19128934 Impact of chronic kidney disease on outcomes of superficial femoral artery endoluminal interventions.Annals of vascular surgeryMore Details
    19704097 Influence of renal function on the effects of early revascularization in non-ST-elevation myocardial infarction: data from the Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies (SWEDEHEART).CirculationMore Details
    19500141 N-acetylcysteine versus N-acetylcysteine + theophylline for the prevention of contrast nephropathy.European journal of clinical investigationMore Details
    19536082 Chronic kidney disease is associated with increased risk of sudden cardiac death among patients with coronary artery disease.Kidney internationalMore Details
    19667039 Progression of cardiac dysfunction in patients with atherosclerotic renovascular disease.QJM : monthly journal of the Association of PhysiciansMore Details
    19766961 Anemia is associated with an elevated serum level of high-molecular-weight adiponectin in patients with type 2 diabetes independently of renal dysfunction.Translational research : the journal of laboratory and clinical medicineMore Details
    19696780 Impact of reduced renal function on prognosis in Japanese patients with coronary artery disease: a prospective cohort of Shinken Database 2007.Hypertension research : official journal of the Japanese Society of HypertensionMore Details
    19892066 Combined role of reduced estimated glomerular filtration rate and microalbuminuria on the prevalence of peripheral arterial disease.The American journal of cardiologyMore Details
    19820133 "Acute decline in renal function, inflammation, and cardiovascular risk after an acute coronary syndrome."Clinical journal of the American Society of Nephrology : CJASNMore Details
    19216014 Focused atorvastatin therapy in managed-care patients with coronary heart disease and CKD.American journal of kidney diseases : the official journal of the National KidneyMore Details
    19201761 Temporal management patterns and outcomes of non-ST elevation acute coronary syndromes in patients with kidney dysfunction.European heart journalMore Details
    19129249 Renal function is associated with arterial stiffness and predicts outcome in patients with coronary artery disease.QJM : monthly journal of the Association of PhysiciansMore Details
    19100672 Hospital performance and differences by kidney function in the use of recommended therapies after non-ST-elevation acute coronary syndromes.American journal of kidney diseases : the official journal of the National KidneyMore Details
    19231381 Impact of preoperative renal dysfunction on in-hospital mortality after solitary valve and combined valve and coronary procedures.The Annals of thoracic surgeryMore Details
    19539072 Impact of the definition utilized on the rate of contrast-induced nephropathy in percutaneous coronary intervention.The American journal of cardiologyMore Details
    19463508 Thrombolysis In Myocardial Infarction (TIMI) risk score and mortality in patients with advanced chronic kidney disease and on dialysis.The American journal of cardiologyMore Details
    19608034 Prognostic value of biomarkers during and after non-ST-segment elevation acute coronary syndrome.Journal of the American College of CardiologyMore Details
    19502379 Relationship between renal function and serum cardiac troponin T in patients with chronic heart failure.European journal of heart failureMore Details
    19166266 Reduced glomerular filtration rate and its association with clinical outcome in older patients at risk of vascular events: secondary analysis.PLoS medicineMore Details
    19194569 "The association between kidney function, coronary artery disease, and clinical outcome in patients undergoing coronary angiography."Journal of Korean medical scienceMore Details
    19151691 Coronary flow reserve is impaired in hypertensive patients with subclinical renal damage.American journal of hypertensionMore Details
    19932791 Relation of kidney function and albuminuria with atrial fibrillation (from the Heart and Soul Study).The American journal of cardiologyMore Details
    19833908 Coronary calcification in patients with chronic kidney disease and coronary artery disease.Clinical journal of the American Society of Nephrology : CJASNMore Details
    19965546 "Longitudinal relationships among coronary artery calcification, serum phosphorus, and kidney function."Clinical journal of the American Society of Nephrology : CJASNMore Details
    19892932 Change in estimated GFR associates with coronary heart disease and mortality.Journal of the American Society of Nephrology : JASNMore Details
    19944316 Plasma granzyme B as a predicting factor of coronary artery disease--clinical significance in patients with chronic renal failure.Journal of cardiologyMore Details
    19541818 Chronic Renal Insufficiency Cohort (CRIC) Study: baseline characteristics and associations with kidney function.Clinical journal of the American Society of Nephrology : CJASNMore Details
    19632521 Plaque characterization of non-culprit lesions by virtual histology intravascular ultrasound in diabetic patients: impact of renal function.Journal of cardiologyMore Details
    19304128 Estimated glomerular filtration rate as a predictor of secondary outcomes in Japanese patients with coronary artery disease.Journal of cardiologyMore Details
    19324131 Impact of renal dysfunction on long-term survival after isolated coronary artery bypass surgery.The Annals of thoracic surgeryMore Details
    19137409 "A comparison of sodium bicarbonate infusion versus normal saline infusion and its combination with oral acetazolamide for prevention of contrast-induced nephropathy: a randomized, double-blind trial."International urology and nephrologyMore Details
    19439990 Factors associated with vascular stiffness: cross-sectional analysis from the Chronic Renal Insufficiency Standards Implementation Study.Nephron. Clinical practiceMore Details
    19212908 Sodium bicarbonate versus normal saline for protection against contrast nephropathy.Renal failureMore Details
    19287180 Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in patients with chronic heart failure and coronary artery disease.Kidney & blood pressure researchMore Details
    18663284 Chronic kidney disease is often unrecognized among patients with coronary heart disease: The REGARDS Cohort Study.American journal of nephrologyMore Details
    19445682 Brain natriuretic peptide levels have diagnostic and prognostic capability for cardio-renal syndrome type 4 in intensive care unit patients."Critical care (London, England)"More Details
    19776568 Serum uric acid for risk stratification of patients with coronary artery disease.CardiologyMore Details
    18928945 Renal impairment is an independent predictor of adverse events post coronary intervention in patients with and without drug-eluting stents.Cardiovascular revascularization medicine : including molecular interventionsMore Details
    18573564 "Coronary artery calcification, arterial stiffness and renal insufficiency associate with serum levels of tumor necrosis factor-alpha in Japanese type 2 diabetic patients."Diabetes research and clinical practiceMore Details
    18694616 Serum folate is associated with coronary heart disease independently of homocysteine in Turkish men."Clinical nutrition (Edinburgh, Scotland)"More Details
    19001197 Rapid kidney function decline and mortality risk in older adults.Archives of internal medicineMore Details
    18562059 Prevalence and associations of coronary artery calcification in patients with stages 3 to 5 CKD without cardiovascular disease.American journal of kidney diseases : the official journal of the National KidneyMore Details
    19128271 Distal embolic protection during renal artery stenting: impact on hypertensive patients with renal dysfunction."Journal of clinical hypertension (Greenwich, Conn.)"More Details
    18325437 Cockcroft-Gault versus modification of diet in renal disease: importance of glomerular filtration rate formula for classification of chronic kidney disease in patients with non-ST-segment elevation acute coronary syndromes.Journal of the American College of CardiologyMore Details
    17984102 "Mortality, kidney disease and cardiac procedures following acute coronary syndrome.""Nephrology, dialysis, transplantation : official publication of the European"More Details
    18383049 Prognostic value of troponins in patients with non-ST-segment elevation acute coronary syndromes and chronic kidney disease.Clinical cardiologyMore Details
    18235089 Association of mild to moderate kidney dysfunction and coronary calcification.Journal of the American Society of Nephrology : JASNMore Details
    18513515 Impact of race and chronic kidney disease on 1-year outcome in patients undergoing percutaneous coronary interventions: a single tertiary center experience.American heart journalMore Details
    18083761 Impact of different stages of chronic kidney disease on in-hospital costs in patients with coronary heart disease."Nephrology, dialysis, transplantation : official publication of the European"More Details
    18443575 Putative role of asymmetric dimethylarginine in microvascular disease of kidney and heart in hypertensive patients.American journal of hypertensionMore Details
    18430270 Effects of statin treatment in men and women with stable coronary heart disease: a subgroup analysis of the GREACE Study.Current medical research and opinionMore Details
    18391103 Kidney dysfunction and sudden cardiac death among women with coronary heart disease.HypertensionMore Details
    18602510 Comparison of the modification of diet in renal disease and the Cockcroft-Gault equations for predicting mortality in patients admitted for exclusion of myocardial ischemia.The American journal of cardiologyMore Details
    18505769 Serial analysis of the vascular endothelial transcriptome under static and shear stress conditions.Physiological genomicsMore Details
    18573389 Long-term survival after cardiac surgery is predicted by estimated glomerular filtration rate.The Annals of thoracic surgeryMore Details
    18178803 Renal insufficiency and mortality in patients with known or suspected coronary artery disease.Journal of the American Society of Nephrology : JASNMore Details
    18068374 Impact of estimated glomerular filtration rate on the 15-year outcome after coronary artery bypass surgery.European journal of cardio-thoracic surgery : official journal of the EuropeanMore Details
    19005288 Impact of admission glomerular filtration rate on the development of poor myocardial perfusion after primary percutaneous intervention in patients with acute myocardial infarction.Coronary artery diseaseMore Details
    18706747 Mortality risks for all causes and cardiovascular diseases and reduced GFR in a middle-aged working population in Taiwan.American journal of kidney diseases : the official journal of the National KidneyMore Details
    18093595 Phosphorus levels are associated with subclinical atherosclerosis in the general population.AtherosclerosisMore Details
    18402899 Intensive lipid lowering with atorvastatin in patients with coronary heart disease and chronic kidney disease: the TNT (Treating to New Targets) study.Journal of the American College of CardiologyMore Details
    18275504 Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in hypertensive and normotensive patients with coronary artery disease."Nephrology (Carlton, Vic.)"More Details
    17826782 "Relations between markers of renal function, coronary risk factors and the occurrence and severity of coronary artery disease."AtherosclerosisMore Details
    18046083 Chronic kidney disease is associated with angiographic coronary artery disease.American journal of nephrologyMore Details
    18025781 Chronic kidney disease as a risk factor for coronary artery disease in Chinese with type 2 diabetes.American journal of nephrologyMore Details
    18239383 Competing risk factor analysis of end-stage renal disease and mortality in chronic kidney disease.American journal of nephrologyMore Details
    18664296 R497K polymorphism in epidermal growth factor receptor gene is associated with the risk of acute coronary syndrome.BMC medical geneticsMore Details
    17452410 Impact of haemoglobin concentration and chronic kidney disease in patients with coronary heart disease undergoing percutaneous coronary interventions."Nephrology, dialysis, transplantation : official publication of the European"More Details
    17803353 Renal function and risk of coronary heart disease in general populations: new prospective study and systematic review.PLoS medicineMore Details
    17803203 Glomerular filtration rate and coronary artery disease burden in patients with acute coronary syndrome.Clinical cardiologyMore Details
    18036453 The cardioprotective effects of the angiotensin-converting enzyme inhibitor perindopril in patients with stable coronary artery disease are not modified by mild to moderate renal insufficiency: insights from the EUROPA trial.Journal of the American College of CardiologyMore Details
    17384009 Multiple biomarker use for detection of adverse events in patients presenting with symptoms suggestive of acute coronary syndrome.Clinical chemistryMore Details
    17384999 Relationship between renal function at the time of percutaneous coronary intervention and prognosis in ischemic heart disease patients.Clinical and experimental nephrologyMore Details
    17336697 Association of cystatin C with poor exercise capacity and heart rate recovery: data from the heart and soul study.American journal of kidney diseases : the official journal of the National KidneyMore Details
    17563020 Cardiovascular disease and subsequent kidney disease.Archives of internal medicineMore Details
    17653515 Inpatients with coronary heart disease have a high prevalence of chronic kidney disease based on estimated glomerular filtration rate (eGFR) in China.Heart and vesselsMore Details
    17066348 Prevalence and prognostic impact of comorbidities in patients with severe aortic valve stenosis.Clinical research in cardiology : official journal of the German Cardiac SocietyMore Details
    17174559 The effect of sodium nitroprusside infusion on renal function during reperfusion period in patients undergoing coronary artery bypass grafting: a prospective randomized clinical trial.European journal of cardio-thoracic surgery : official journal of the EuropeanMore Details
    17724052 Comorbidities in UK patients at the start of renal replacement therapy (chapter 6)."Nephrology, dialysis, transplantation : official publication of the European"More Details
    16905139 Renal dysfunction increases the risk of saphenous vein graft occlusion: results from the Post-CABG trial.AtherosclerosisMore Details
    17210589 Association of cystatin C and estimated GFR with inflammatory biomarkers: the Heart and Soul Study."Nephrology, dialysis, transplantation : official publication of the European"More Details
    17369136 Cardiac troponin risk stratification based on 99th percentile reference cutoffs in patients with ischemic symptoms suggestive of acute coronary syndrome: influence of estimated glomerular filtration rates.American journal of clinical pathologyMore Details
    17344421 Reduced kidney function as a risk factor for incident heart failure: the atherosclerosis risk in communities (ARIC) study.Journal of the American Society of Nephrology : JASNMore Details
    18949085 Statin-Induced Increase in HDL-C and Renal Function in Coronary Heart Disease Patients.The open cardiovascular medicine journalMore Details
    16877529 Heparin binding EGF is necessary for vasospastic response to endothelin.FASEB journal : official publication of the Federation of American Societies for More Details
    17112858 "Hepcidin, an acute-phase protein and a marker of inflammation in kidney transplant recipients with and without coronary artery disease."Transplantation proceedingsMore Details
    16574688 Refined characterization of the association between kidney function and mortality in patients undergoing cardiac catheterization.European heart journalMore Details
    16801465 Renal function and effectiveness of angiotensin-converting enzyme inhibitor therapy in patients with chronic stable coronary disease in the Prevention of Events with ACE inhibition (PEACE) trial.CirculationMore Details
    16490816 Renal function and outcome from coronary artery bypass grafting: impact on mortality after a 2.3-year follow-up.CirculationMore Details
    17175295 "Resistin, a new adipokine, is related to inflammation and renal function in kidney allograft recipients."Transplantation proceedingsMore Details
    16564937 Use of beta-blockers and aspirin after myocardial infarction by patient renal function in the Department of Defense health care system.American journal of kidney diseases : the official journal of the National KidneyMore Details
    15619387 Contrast-induced nephropathy after percutaneous coronary interventions in relation to chronic kidney disease and hemodynamic variables.The American journal of cardiologyMore Details
    15673320 Low hematocrit predicts contrast-induced nephropathy after percutaneous coronary interventions.Kidney internationalMore Details
    10916078 Angiotensin II-induced growth of vascular smooth muscle cells requires an Src-dependent activation of the epidermal growth factor receptor.Kidney internationalMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 301 unique genes interacted with EGFR. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    SHC1 Affinity Capture-MS16729043|9544989|19531499|19531499|9756944|9130710|11370743|11408594|10595738|18271526|10049786|10635327 No
    SH3BGRL Affinity Capture-MS16729043 No
    STAT5A Affinity Capture-MS16729043|16729043 No
    PTPN11 Affinity Capture-MS16729043|7673163|9756944 CHD related
    CRK Affinity Capture-MS16729043|9642287|10595738|9617486|9642287,12198159,11956190,8875975,9480911 No
    CSK Affinity Capture-MS16729043 No
    CBLB Affinity Capture-MS16729043|10086340|16702950|19531499|11375397|18271526 No
    GRB2 Affinity Capture-MS16729043|7527043|7527043|9050991|8647858|7510700|17971399|17242169|19531499|19531499|21596750|11370743|11408594|10595738|7592693|19289468|18271526|1322798,7527043,8662998,12577067,14679214,8887653,11726515,8810325,7518560,16799092 CHD related
    STAT3 Affinity Capture-Western15485908|10358079|15950906|15950906|9756944|21573184|12873986 CHD related
    CTNNB1 Reconstituted Complex9535896|11950845|9233779|9233779 CHD related
    CTNND1 Reconstituted Complex9535896|14996911 No
    JUP Reconstituted Complex9535896 CHD related
    AR Affinity Capture-Western15305378|15288768|12534934,15288768 CHD related
    EGFR Affinity Capture-Western14576349|19225046|18271526|11279102,12397069,12009895,8940083,11114724,8845374,11983694,9363897,10635327,16274239,16777603,12297050 CHD related
    TJP1 Affinity Capture-Western12708492 No
    INPPL1 Affinity Capture-Western11349134 No
    AREG Reconstituted Complex10085134|10085134 No
    CBL Affinity Capture-Western10086340|12061819|18316398|18508924|18273061|18273061|17995934|17971399|17545148|17486068|16969069|16246327|16105874|15668240|15282549|15159412|15107835|14505571|12734385|12604776|12593795|10428778|17242169|21772844|19225046|19531499|19531499|19531499|19713535|15210722|15210722|20940296|15962011|14627991|22591401|16849543|15465819|9756944|9130710|11370743|17880946|15383614|19836242|22833562|19578043|17182860|16923119|11408594|7782294|7592693|18271526|10635327|8662998,11994282,11239464,9890970,10092522,10799548,16729043,7657591,8798643,18273061 No
    STAT1 Affinity Capture-Western10358079|12070153|12070153,7657660,11294897,10918587,15322115,7543024,11839738,12817007,7690989,12637327 CHD related
    PTK6 Affinity Capture-Western8940083 No
    PTK2B Affinity Capture-Western10777553 No
    IGF1R Affinity Capture-Western17047074|17307140 CHD related
    PRKAR1A Affinity Capture-Western9050991 CHD related
    PRKACA Affinity Capture-Western9050991 CHD related
    PLD2 Affinity Capture-Western9837959|9837959 CHD related
    ARF4 Two-hybrid12446727|12446727 No
    PTPN6 Affinity Capture-Western7673163 No
    GRB14 Reconstituted Complex8647858 No
    RASA1 Reconstituted Complex8647858|1633149,1850098 No
    NRG1 Affinity Capture-Western7730382 CHD related
    PLCG1 Affinity Capture-Western12061819|9756944|9207933,8885868,8657103,1689310,7682059,15144186,12601080 CHD related
    SH3KBP1 Affinity Capture-Western11894095|15456872|12734385|21635887|16849543|12771190 No
    SOCS1 Affinity Capture-Western12070153 CHD related
    SOCS3 Affinity Capture-Western12070153 CHD related
    CAV1 Affinity Capture-Western9374534|9374534|16407214|19446582|9374534,16799092 CHD related
    CAV3 Affinity Capture-Western9374534|9374534 CHD related
    ERBB3 Affinity Capture-Western10527633 No
    STAT5B Affinity Capture-Western10558875|10558875,11751923 No
    CEBPB Affinity Capture-Western12095417 No
    GAB1 Affinity Capture-Western11432805|18271526|11432805,10734310 No
    RIPK1 Affinity Capture-Western11116146 No
    MAP3K14 Affinity Capture-Western11116146 No
    PDGFRB Affinity Capture-Western9506992 No
    UBC Affinity Capture-Western18632619|18316398|18508924|17995934|17971399|17545148|17382318|17101784|16983337|16969069|16914641|16735510|16246327|16205628|16120644|16105874|15701692|15635092|15475003|15456872|15345710|15282549|16702950|15159412|14505571|12719435|12717448|12381737|12226085|12006662|12006493|11994282|11983899|11823423|11493652|10617627|10428778|10369675|19270726|19144635|21772844|20124286|20359967|19213840|19531499|19531499|19531499|20215522|19446582|21275903|20736164|22179831|16520378|15273720|15210722|20940296|17121848|15962011|22591401|15465819|15113837|11375397|19836242|15828871|19054389|21044682|16780213|11239464|10635327 No
    HGS Affinity Capture-Western18508924|15212941|12953068 No
    NCAM1 Reconstituted Complex17995934 CHD related
    Usp8 Affinity Capture-Western17720156|17121848 No
    HDAC6 Affinity Capture-Western20133936|20029029|20029029 No
    AIP PCA20029029 No
    PSMA7 PCA20029029 No
    MEGF6 PCA20029029 No
    SORBS2 PCA20029029 No
    HEXIM1 PCA20029029 No
    AHSA1 PCA20029029 No
    ALDOA PCA20029029 No
    UROD PCA20029029 No
    UCHL1 PCA20029029 No
    HSP90B1 PCA20029029 No
    CBR1 PCA20029029 No
    FAH PCA20029029 No
    GOT1 PCA20029029 No
    RAB3A PCA20029029 No
    CSRP1 PCA20029029 No
    CFL1 PCA20029029 No
    EEF1G PCA20029029 No
    PRKAR1B PCA20029029 No
    ATIC PCA20029029 No
    STIP1 PCA20029029 No
    HSPA4 PCA20029029|20029029|12006493|18271526 No
    MDH1 PCA20029029 No
    PTGDS PCA20029029 CHD related
    MATR3 PCA20029029 No
    SEPP1 PCA20029029 No
    OAZ1 PCA20029029 No
    PSMD4 PCA20029029 No
    TPI1 PCA20029029 No
    GABARAPL2 PCA20029029 No
    ARF6 PCA20029029 No
    CNTN2 PCA20029029 No
    FKBP4 PCA20029029 No
    AKAP12 PCA20029029 No
    PTPN12 PCA20029029 No
    PRDX1 PCA20029029|18271526 CHD related
    AHNAK PCA20029029 No
    MAP3K12 PCA20029029|20029029 No
    GPM6B PCA20029029 No
    DCTN2 PCA20029029 No
    COL9A3 PCA20029029 No
    DYNC1H1 PCA20029029 No
    FKBP8 PCA20029029 No
    SPCS2 PCA20029029 No
    PDK3 PCA20029029 No
    UBE2V2 PCA20029029 No
    ADRM1 PCA20029029 No
    RAP1GDS1 PCA20029029 No
    HSPA8 PCA20029029 CHD related
    PPP5C PCA20029029 No
    HSPA1A PCA20029029 CHD related
    FN1 PCA20029029 CHD related
    TPM1 PCA20029029 CHD related
    KCTD9P2 PCA20029029 No
    TMCO3 PCA20029029 No
    CEND1 PCA20029029 No
    RUSC2 PCA20029029 No
    SPARCL1 PCA20029029 No
    C4orf49 PCA20029029 No
    PRCC PCA20029029 No
    AP2M1 PCA20029029 No
    NDN PCA20029029 No
    OLFM1 PCA20029029 No
    DNAJC4 PCA20029029 No
    VAPA PCA20029029 No
    STUB1 PCA20029029 No
    PIN4 PCA20029029 No
    MAST1 PCA20029029 No
    MOB4 PCA20029029 No
    CCDC50 Affinity Capture-Western16803894 No
    NEDD8 Affinity Capture-Western16735510 No
    EPN1 Affinity Capture-Western15701692|21226813 No
    PDCD6IP Affinity Capture-Western15456872|12771190 No
    SH3GL2 Affinity Capture-Western15456872 No
    UBASH3B Affinity Capture-Western15159412|17880946|18271526 No
    HSP90AA1 Affinity Capture-Western12006493|16849543|16024644 CHD related
    SPRY2 Affinity Capture-Western11983899 No
    TNK2 Affinity Capture-Western20086093|17182860|18435854|18271526 No
    LGALS1 Affinity Capture-Western19225046 No
    LGALS3 Affinity Capture-Western19225046 No
    PIK3R2 Affinity Capture-MS19531499|11172806 No
    SNRPD2 Affinity Capture-MS19531499 No
    ACTA2 Affinity Capture-MS19531499 CHD related
    PIK3R1 Affinity Capture-MS19531499|21701776 CHD related
    ERRFI1 Affinity Capture-MS19531499|18271526 No
    MTCO2P1 Affinity Capture-MS19531499 No
    YWHAZ Affinity Capture-MS19531499 No
    SMURF2 Affinity Capture-Western21750651 No
    CALM1 Affinity Capture-Western14960328|12153558 No
    ATXN2 Affinity Capture-Western18602463 No
    EPS8 Affinity Capture-Western11408594 No
    STAM2 Affinity Capture-Western17403676|15212941|11687594,10993906 No
    RIN1 Affinity Capture-Western17403676 No
    EMD Co-fractionation20937808|20937808 No
    SEC61A1 Co-localization20937808 No
    RBM10 Affinity Capture-MS18271526 No
    TRAF2 Affinity Capture-MS18271526 No
    HNRNPH1 Affinity Capture-MS18271526 No
    BCLAF1 Affinity Capture-MS18271526 No
    C11orf84 Affinity Capture-MS18271526 No
    DOCK4 Affinity Capture-MS18271526 No
    MYCBP Affinity Capture-MS18271526 No
    CRKL Affinity Capture-MS18271526 No
    TAB1 Affinity Capture-MS18271526 No
    RIOK1 Affinity Capture-MS18271526 No
    JAK1 Affinity Capture-MS18271526 CHD related
    CDK1 Affinity Capture-MS18271526 CHD related
    DDX60 Affinity Capture-MS18271526 No
    ODF3L2 Affinity Capture-MS18271526|18271526 No
    HCFC1 Affinity Capture-MS18271526 No
    IRS2 Affinity Capture-MS18271526 CHD related
    RBM41 Affinity Capture-MS18271526 No
    PICALM Co-fractionation22939629 No
    MPV17 Co-fractionation22939629 No
    CALM2 in vitro;in vivo12153558 No
    CALM3 in vitro;in vivo12153558 No
    PAK1 in vitro;in vivo12522133 CHD related
    ACTA1 in vitro;in vivo1808202,1383230 CHD related
    MET in vitro;in vivo10722725 No
    ERBB4 in vitro10572067 No
    FAS in vitro;in vivo12586732 CHD related
    MAP2K1 in vitro;in vivo12556561 CHD related
    EPHA2 in vivo15657067 No
    MAPK1 in vitro;in vivo12556561 CHD related
    ELF3 in vitro1651322 No
    PLD1 in vivo11459228 No
    HIST3H3 in vitro;in vivo12577067 No
    PRKD1 in vivo10523301,2984676,2987962 No
    UBB in vivo12218189 No
    EZR in vitro;in vivo1382070,12560083 No
    CAV2 in vivo16799092 No
    CLTA in vivo16799092 No
    CLTCL1 in vivo16799092 No
    HOXC10 in vivo16799092 No
    LYN in vivo16799092 No
    S100A7 in vivo16799092 No
    S100A9 in vivo16799092 CHD related
    SEC13 in vivo16799092 No
    GAPDH in vivo16799092 No
    SFN in vivo16799092 No
    SLC3A2 in vivo16799092 No
    ATP1A1 in vivo16799092 No
    ATP1B1 in vivo16799092 No
    ICAM1 in vivo16799092 CHD related
    TUBA4A in vivo16799092 No
    ALCAM in vivo16799092 No
    SOCS5 in vivo15695332 No
    PIK3C2A in vivo10805725 No
    SH3BGRL3 in vitro;in vivo16729043 No
    ADRBK1 in vivo15620700 CHD related
    EPB41 in vitro;in vivo1647028 No
    SLC9A3R1 in vitro16456542 No
    TUBA1A in vivo16799092 No
    PKIA in vitro2434500 No
    SCAMP1 in vivo9658162 No
    SCAMP3 in vitro;in vivo9658162,15144186 No
    DCN Two-hybrid12105206|12105206|9988678 CHD related
    LRSAM1 Affinity Capture-Western15256501 No
    CAMLG Affinity Capture-Western12919676|12919676 No
    PRKCA Affinity Capture-Western12878187|8375396|12878187 CHD related
    HBEGF Affinity Capture-Western12725245 No
    ATP5C1 Two-hybrid16169070|16169070 No
    SGSM2 Two-hybrid16169070 No
    Grap2 Affinity Capture-Western9872323 No
    WAS Affinity Capture-Western9307968 No
    EGF Reconstituted Complex12093292 CHD related
    DUSP3 Biochemical Activity1281549 No
    PTK2 Affinity Capture-Western10806474|10806474 No
    CBLC Affinity Capture-Western10571044|10362357|10362357|22888118|22888118|22888118|10362357 No
    CDH1 Affinity Capture-Western10969083|10969083 No
    MAPK14 Biochemical Activity7535770 CHD related
    VAV1 Affinity Capture-Western10938113|10938113 No
    VAV2 Affinity Capture-Western10938113|20940296 No
    VAV3 Affinity Capture-Western10938113|11094073 No
    SRC Affinity Capture-Western10358079|17158602|21573184|20333651|11983694,8845374,10075741 CHD related
    JAK2 Affinity Capture-Western10358079|9363897,10635327 CHD related
    HTT Affinity Capture-Western9079622|9079622 No
    DOK2 Reconstituted Complex10508618|10508618 No
    SOS1 Affinity Capture-Western10675333|9447973|9447973 No
    SOS2 Affinity Capture-Western10675333|10675333 No
    CDC25A Affinity Capture-Western11912208|11912208|11912208 No
    NCK1 Reconstituted Complex9362449|1333047|10026169|9362449 No
    MAP4K1 Co-fractionation9346925|9346925 No
    NCK2 Reconstituted Complex9737977|10026169|9843575|9737977,1333047 No
    EPS15 Affinity Capture-Western9049247|19109251|16429130 No
    ROS1 Affinity Capture-Western11094073 No
    SH2D3A Affinity Capture-Western10187783|10187783 No
    PLSCR1 Co-fractionation12009895|12009895,12871937 No
    GRB10 Reconstituted Complex9506989|9006901,9506989 No
    PTPN1 Co-crystal Structure10889023|8621392 CHD related
    CD44 Affinity Capture-Western12093135 CHD related
    PIK3C2B Reconstituted Complex11533253|11533253,10805725 No
    TGFA Co-crystal Structure12297049|12297049 No
    CD82 Affinity Capture-Western10985391|10985391 No
    SNX6 Affinity Capture-Western11279102|11279102 No
    SNX1 Affinity Capture-Western9819414|9819414,8638121 No
    SNX2 Affinity Capture-Western9819414|9819414 No
    SNX4 Affinity Capture-Western9819414|9819414 No
    RGS16 Affinity Capture-Western11602604 No
    MUC1 Affinity Capture-Western11278868|11483589 No
    SHC3 Affinity Capture-Western9507002|9507002 No
    CASP1 Biochemical Activity11226410|11226410 CHD related
    EREG Affinity Capture-Luminescence9419975|9419975 No
    FER Affinity Capture-Western7623846|7623846 No
    ERBB2 Affinity Capture-Western19060928|17486068 CHD related
    PCNA Affinity Capture-Western17115032 CHD related
    LRIG1 Affinity Capture-Western15345710|15282549|18542056 No
    UBASH3A Affinity Capture-Western15159412 No
    NDFIP1 Affinity Capture-Western20534535 No
    NDFIP2 Affinity Capture-Western20534535 No
    NEDD4 Biochemical Activity19953087|19953087 No
    ZFYVE28 Co-localization19460345 No
    OTUD7B Affinity Capture-Western22179831 No
    USP2 Affinity Capture-Western22370483 No
    YAP1 Affinity Capture-Western12807903 No
    CD2AP Affinity Capture-Western12672817 No
    PRKCB Biochemical Activity9815893 CHD related
    HDAC2 Negative Genetic22318606 CHD related
    H2AFX Affinity Capture-Western21704408 No
    PPP2R3A Affinity Capture-Western19825976 No
    RABGEF1 Affinity Capture-Western16499958 No
    PTPRJ Affinity Capture-Western19836242|19836242|9115287 No
    SOCS4 Protein-peptide17997974 No
    SEC61B Affinity Capture-Western19602593 No
    TOM1L1 Affinity Capture-Western19798056 No
    CALU Co-fractionation22939629 CHD related
    PTPRS in vivo10435588 No
    CEACAM1 in vitro;in vivo15467833 No
    ANXA1 in vivo15581623 CHD related
    SOCS7 in vitro9344857 No
    CMTM8 in vivo16263120 No
    ESR1 in vitro11887937 CHD related
    ITGA5 in vitro;in vivo10888683 CHD related
    GNAI2 in vivo11286993 No
    KRT7 in vitro;in vivo12577067 No
    KRT8 in vitro;in vivo12577067 No
    KRT17 in vitro;in vivo12577067 No
    KRT18 in vitro;in vivo12577067 No
    XRCC6 in vivo9430697 No
    PRKCD in vivo2987962,2984676 CHD related
    TNC in vitro;in vivo11470832 CHD related
    MT-CO2 in vitro;in vivo15282306 No
    PITPNA in vitro;in vivo7761838 No
    BTC in vivo9528863 No
    AMH in vitro8596488 No
    PLEC1 in vitro;in vivo12577067 No
    GRB7 in vitro;in vivo9710451 No
    CAMK2G in vitro1309762,10347170 CHD related
    ZNF259 in vivo10938113,8650580 CHD related
    EPPK1 in vitro;in vivo12577067 No
    CAMK2A in vitro1309762,10347170 CHD related
    PTPN2 in vitro;in vivo9488479,15588985 No
    DEGS1 in vitro;in vivo;yeast 2-hybrid9188692 No
    AGTR1 in vitro12522132 CHD related


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB00002CetuximabFor treatment of EGFR-expressing metastatic colorectal cancer in patients who are refractory to other irinotecan-based chemotherapy regimens. Cetuximab is also indicated for treatment of squamous cell carcinoma of the head and neck in conjucntion with radiation therapy.L01XC06
    approvedDB00072Trastuzumab"For treatment of early stage HER2-positive breast cancer, or metastatic breast cancer that substantially overexpress HER2."L01XC03
    approvedDB00281LidocaineFor production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks.C01BB01;C05AD01;D04AB01;N01BB02;R02AD02;S01HA07;S02DA01;A01AD11
    approvedDB00317GefitinibFor the continued treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of either platinum-based or docetaxel chemotherapies.L01XE02
    approvedDB00530Erlotinib"For the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of at least one prior chemotherapy regimen. Also for use, in combination with gemcitabine, as the first-line treatment of patients with locally advanced, unresectable or metastatic pancreatic cancer."L01XE03
    approvedDB01259Lapatinib"Indicated in combination with capecitabine for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress the human epidermal receptor type 2 (HER2) protein and who have received prior therapy including an anthracycline, a taxane, and trastuzuma."L01XE07
    approvedDB01269Panitumumab"For the treatment of EGFR-expressing, metastatic colorectal carcinoma that is refractory to fluoropyrimidine-, oxaliplatin-, and irinotecan- containing chemotherapy regimens."L01XC08
    experimentalDB03496Flavopiridol"Investigated for use/treatment in esophageal cancer, leukemia (lymphoid), lung cancer, liver cancer, and lymphoma (unspecified)."
    experimentalDB07602S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE
    experimentalDB07662N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE