How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: ENO1

    Description: "enolase 1, (alpha)"

    Entrez Gene ID: 2023

    SwissProt Acc Number: P06733

    RefSeq: NM_001428

    It was suspected to be CHD related:

    .."Finally, we tested these 24 SNPs in a third study (475 cases and 619 controls) and found that 5 SNPs in 4 genes (ENO1, FXN (2 SNPs), HLA-DPB2, and LPA) were associated with MI in the third study (1-sided P<0.05), "..

    From PMID: 18682748, in Journal PLoS One. , 2008


    References

    There were 1 potential papers with ENO1 and CHD.

    PMIDTitleJournalsDetails
    18682748 "Analysis of 17,576 potentially functional SNPs in three case-control studies of myocardial infarction."PloS oneMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 46 unique genes interacted with ENO1. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    PLG Reconstituted Complex11169399 No
    TRAPPC2 Two-hybrid11134351|11134351|11134351 No
    HDAC1 Reconstituted Complex10403782|10403782 CHD related
    IVNS1ABP Affinity Capture-Western17996313 No
    PGK1 Co-fractionation22939629 No
    GAPDH Co-fractionation22939629 No
    TPI1 Co-fractionation22939629 No
    FLNC Co-fractionation22939629 No
    PPIA Co-fractionation22939629 CHD related
    ITPA Co-fractionation22939629 No
    ENO3 Co-fractionation22939629 No
    FANCA Two-hybrid14499622 No
    ISG15 Affinity Capture-MS16884686|16009940|16815975 No
    MAP2K5 Affinity Capture-Western15805119 No
    SUMO2 Affinity Capture-MS19394292 No
    UBC Affinity Capture-MS16335966|16196087|17623298|18781797|21987572|20972266|21963094|21139048|21890473|21906983|22536838|22053931|21853274|22505724 No
    H2AFX Affinity Capture-MS20000738 No
    CD4 Affinity Capture-MS15047060 CHD related
    Mapk13 Affinity Capture-MS19135240 No
    YWHAQ Affinity Capture-MS15161933 No
    YWHAZ Affinity Capture-MS15324660|15324660 No
    INSIG2 Affinity Capture-MS19815544 No
    PCNA Affinity Capture-MS20849852|20849852 CHD related
    GRB2 Two-hybrid18624398 CHD related
    PSMA3 Affinity Capture-MS22079093 No
    KIAA0101 Affinity Capture-MS21628590 No
    SUMO4 Affinity Capture-MS16236267|16236267 CHD related
    SUMO1 Affinity Capture-MS21110914 No
    Lyn Biochemical Activity14604964 No
    FBXO25 Affinity Capture-MS20473970 No
    CUL3 Affinity Capture-MS21145461 No
    CUL4A Affinity Capture-MS21145461 No
    CUL4B Affinity Capture-MS21145461 No
    CUL5 Affinity Capture-MS21145461 No
    CUL2 Affinity Capture-MS21145461 No
    CDK2 Affinity Capture-MS21319273 No
    CUL1 Affinity Capture-MS21145461 No
    COPS5 Affinity Capture-MS21145461 No
    CAND1 Affinity Capture-MS21145461 No
    MYOC Far Western16289162|16289162 No
    AGTPBP1 Two-hybrid16713569 No
    AKT1 Affinity Capture-MS16027165 CHD related
    FYN Biochemical Activity14530346|11078745 No
    UBD Affinity Capture-MS22797925 No
    SRC Biochemical Activity11078745 CHD related
    Htt Affinity Capture-MS17500595 No


    Involved FDA drugs

    There was no drug associated with ENO1