How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
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    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: ENPP1

    Description: ectonucleotide pyrophosphatase/phosphodiesterase 1

    Entrez Gene ID: 5167

    SwissProt Acc Number: P22413

    RefSeq: NM_006208

    It was suspected to be CHD related:

    .."Recently, homozygous or compound heterozygous mutations for the ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) gene were reported as causative for the disorder. "..

    From PMID: 22629037, in Journal J Cardiovasc Dis Res , 2012


    There were 9 potential papers with ENPP1 and CHD.

    23040839 Genetic pathways of vascular calcification.Trends in cardiovascular medicineMore Details
    22629037 Molecular diagnosis of generalized arterial calcification of infancy (GACI).Journal of cardiovascular disease researchMore Details
    21282363 The ENPP1 Q121 variant predicts major cardiovascular events in high-risk individuals: evidence for interaction with obesity in diabetic patients.DiabetesMore Details
    21076580 ENPP1 K121Q Genotype Not Associated with Coronary Artery Calcification in Korean Patients with Type 2 Diabetes Mellitus.Korean diabetes journalMore Details
    21151691 Idiopathic infantile arterial calcification: a rare cause of sudden unexpected death in childhood.Pathology research internationalMore Details
    17848394 Impact of ENPP1 genotype on arterial calcification in patients with end-stage renal failure."Nephrology, dialysis, transplantation : official publication of the European"More Details
    17129580 The association of PC-1 (ENPP1) K121Q polymorphism with metabolic syndrome in patients with coronary heart disease.Clinica chimica acta; international journal of clinical chemistryMore Details
    17491709 "ENPP1 K121Q polymorphism is not related to type 2 diabetes mellitus, features of metabolic syndrome, and diabetic cardiovascular complications in a Chinese population."The review of diabetic studies : RDSMore Details
    15940697 Generalized arterial calcification of infancy: different clinical courses in two affected siblings.American journal of medical genetics. Part AMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 3 unique genes interacted with ENPP1. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    INSR Affinity Capture-Western10615944|10615944 No
    SQSTM1 Affinity Capture-MS20562859 No
    FBXO6 Affinity Capture-MS22268729 No

    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approvedDB00811RibavirinFor the treatment of chronic hepatitis C and for respiratory syncytial virus (RSV).J05AB04
    approvedDB01143AmifostineFor reduction in the cumulative renal toxicity in patients with ovarian cancer (using cisplatin) and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.V03AF05