How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: EPO

    Description: erythropoietin

    Entrez Gene ID: 2056

    SwissProt Acc Number: P01588

    RefSeq: NM_000799

    It was suspected to be CHD related:

    .."Growth factors like vascular endothelial growth factor (VEGF) as well as erythropoietin (EPO) are known to modulate the bioavailability of nitric oxide and, thereby, contribute to the maintenance of a normal vascular tone"..

    From PMID: 21450569, in Journal Eur J Prev Cardiol , 2012


    There were 41 potential papers with EPO and CHD.

    23806450 High-dose erythropoietin during cardiac resuscitation lessens postresuscitation myocardial stunning in swine.Translational research : the journal of laboratory and clinical medicineMore Details
    23648638 "Suppression of coronary atherosclerosis by helix B surface Peptide, a nonerythropoietic, tissue-protective compound derived from erythropoietin.""Molecular medicine (Cambridge, Mass.)"More Details
    22563215 Erythropoietin improves long-term outcomes in patients with acute kidney injury after coronary artery bypass grafting.Journal of Korean medical scienceMore Details
    21450569 Exercise training restores the endothelial response to vascular growth factors in patients with stable coronary artery disease.European journal of preventive cardiologyMore Details
    21532003 Prevalence of clinical and subclinical thyroid disease in a peritoneal dialysis population.Peritoneal dialysis international : journal of the International Society forMore Details
    22038108 Effects of erythropoietin on angiogenesis after myocardial infarction in porcine.Heart and vesselsMore Details
    21069412 Effect of anemia on cardiac disorders in pre-dialysis patients immediately before starting hemodialysis.Clinical and experimental nephrologyMore Details
    22214710 Alterations of serum erythropoietin and thrombopoietin levels in patients undergoing Coronary Artery Bypass Grafting (CABG).Clinical hemorheology and microcirculationMore Details
    20354038 Evaluation of early and late postoperative flow capacity of internal thoracic artery bypass by means of stress Doppler echocardiography.Interactive cardiovascular and thoracic surgeryMore Details
    20610234 Prolonged therapy with erythropoietin is safe and prevents deterioration of left ventricular systolic function in a porcine model of myocardial infarction.Journal of cardiac failureMore Details
    20630406 Erythropoiesis stimulation in acute ischemic syndromes.Heart failure clinicsMore Details
    20028188 Is there a role for erythropoietin in cardiovascular disease?Expert opinion on biological therapyMore Details
    20809214 Cytokine combination therapy with erythropoietin and granulocyte colony stimulating factor in a porcine model of acute myocardial infarction.Cardiovascular drugs and therapy / sponsored by the International Society ofMore Details
    20870805 Erythropoietin enhances hydrogen peroxide-mediated dilatation of canine coronary collateral arterioles during myocardial ischemia in dogs in vivo.American journal of physiology. Heart and circulatory physiologyMore Details
    20849606 Local erythropoietin and endothelial progenitor cells improve regional cardiac function in acute myocardial infarction.BMC cardiovascular disordersMore Details
    19440068 Failure of erythropoietin to render jeopardized ischemic myocardium amenable to incremental salvage by early reperfusion.Coronary artery diseaseMore Details
    19617412 Myocardial reperfusion injury management: erythropoietin compared with postconditioning.American journal of physiology. Heart and circulatory physiologyMore Details
    18596374 Chronic erythropoietin treatment decreases post-infarct myocardial damage in rats without venous thrombogenic effect.CardiologyMore Details
    19212904 Cardiovascular risk factors in non-diabetic hemodialysis patients: a comparative study.Renal failureMore Details
    18077209 Low-dose erythropoietin improves cardiac function in experimental heart failure without increasing haematocrit.European journal of heart failureMore Details
    17999641 Erythropoietin in cardiovascular diseases: exploring new avenues."Clinical science (London, England : 1979)"More Details
    18327705 "Erythropoietin stimulates normal endothelial progenitor cell-mediated endothelial turnover, but attributes to neovascularization only in the presence of local ischemia."Cardiovascular drugs and therapy / sponsored by the International Society ofMore Details
    17925614 The potential of erythropoietin for conferring cardioprotection complementing reperfusion.Coronary artery diseaseMore Details
    17242014 Attenuation of cardiac remodelling by endocardial injection of erythropoietin: ultrasonic strain-rate imaging in a model of hibernating myocardium.European heart journalMore Details
    17412728 Early haemoglobin-independent increase of plasma erythropoietin levels in patients with acute myocardial infarction.European heart journalMore Details
    17106196 Erythropoietin enhances the angiogenic potency of autologous bone marrow stromal cells in a rat model of myocardial infarction.CardiologyMore Details
    17998053 Constitutively overexpressed erythropoietin reduces infarct size in a mouse model of permanent coronary artery ligation.Methods in enzymologyMore Details
    16775632 AAV serotype-1 mediates early onset of gene expression in mouse hearts and results in better therapeutic effect.Gene therapyMore Details
    16788333 Cardiovascular effects of erythropoietin: anemia and beyond.Cardiology in reviewMore Details
    16949468 "The interaction between heart failure and other heart diseases, renal failure, and anemia."Seminars in nephrologyMore Details
    16464635 Percutaneous endocardial injection of erythropoietin: assessment of cardioprotection by electromechanical mapping.European journal of heart failureMore Details
    16336978 Mechanism of the cardioprotection of rhEPO pretreatment on suppressing the inflammatory response in ischemia-reperfusion.Life sciencesMore Details
    16377761 Alteration in erythropoietin-induced cardioprotective signaling by postinfarct ventricular remodeling.The Journal of pharmacology and experimental therapeuticsMore Details
    16868702 "Anemia, chronic renal disease and congestive heart failure--the cardio renal anemia syndrome: the need for cooperation between cardiologists and nephrologists."International urology and nephrologyMore Details
    16117735 Lack of acute cardioprotective effect from preischaemic erythropoietin administration in a porcine coronary occlusion model.Clinical physiology and functional imagingMore Details
    15992646 Erythropoietin induces neovascularization and improves cardiac function in rats with heart failure after myocardial infarction.Journal of the American College of CardiologyMore Details
    15883754 Erythropoietin just before reperfusion reduces both lethal arrhythmias and infarct size via the phosphatidylinositol-3 kinase-dependent pathway in canine hearts.Cardiovascular drugs and therapy / sponsored by the International Society ofMore Details
    16281960 The epidemiology and control of anaemia among pre-ESRD patients with chronic kidney disease.European journal of clinical investigationMore Details
    15556046 Erythropoietin improves left ventricular function and coronary flow in an experimental model of ischemia-reperfusion injury.European journal of heart failureMore Details
    12702503 Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization.BloodMore Details
    11849404 Relevance of C-reactive protein levels in peritoneal dialysis patients.Kidney internationalMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 1 unique genes interacted with EPO. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    EPOR Reconstituted Complex10318834|9808045|17327410 No

    Involved FDA drugs

    There was no drug associated with EPO