Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)
Website using assistance : Leihong Wu (11019004@zju.edu.cn)
Coronary Heart Disease Research Platform
Description: fatty acid desaturase 1
Entrez Gene ID: 3992
SwissProt Acc Number: O60427
RefSeq: NM_013402
It was suspected to be CHD related:
.."In this case-control study, CAD patients (n=756, 40-79 years) and healthy controls (n=890) were genotyped for rs174537 near FADS1 (FEN1 rs174537G>T), FADS2 (rs174575, rs2727270), and FADS3 (rs1000778). The rs174537T is associated with a lower proportion of AA in serum phospholipids and reduced CAD risk, in association with reduced total- and LDL-cholesterol and lipid peroxides."..
From PMID: 21040914, in Journal Atherosclerosis. , 2011There were 8 potential papers with FADS1 and CHD.
| PMID | Title | Journals | Details |
|---|---|---|---|
| 23362303 | Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. | Circulation. Cardiovascular genetics | More Details |
| 23555103 | A case-control study between gene polymorphisms of polyunsaturated fatty acid metabolic rate-limiting enzymes and acute coronary syndrome in Chinese Han population. | BioMed research international | More Details |
| 22503634 | Genetic adaptation of fatty-acid metabolism: a human-specific haplotype increasing the biosynthesis of long-chain omega-3 and omega-6 fatty acids. | American journal of human genetics | More Details |
| 22911844 | Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study. | PloS one | More Details |
| 22701466 | "Variants in CPT1A, FADS1, and FADS2 are Associated with Higher Levels of Estimated Plasma and Erythrocyte Delta-5 Desaturases in Alaskan Eskimos." | Frontiers in genetics | More Details |
| 21040914 | "FADS gene polymorphisms in Koreans: association with omega6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease." | Atherosclerosis | More Details |
| 21917437 | A case-control study between the gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and coronary artery disease in a Chinese Han population. | "Prostaglandins, leukotrienes, and essential fatty acids" | More Details |
| 20558833 | Genetic variants in the metabolism of omega-6 and omega-3 fatty acids: their role in the determination of nutritional requirements and chronic disease risk. | "Experimental biology and medicine (Maywood, N.J.)" | More Details |
NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.
There were totally 3 unique genes interacted with FADS1. Show PPI network
| Gene name | Interaction type | reference PMID | CHD relation |
|---|---|---|---|
| PAAF1 | Affinity Capture-MS | 17353931 | No |
| DHCR7 | Affinity Capture-MS | 17353931 | No |
| UBC | Affinity Capture-MS | 18781797|21987572|21139048|21890473|21906983|22505724 | No |
| Status | DrubBank ID | Name | Indication | ATC Code |
|---|---|---|---|---|
| approved;nutraceutical | DB00132 | Alpha-Linolenic Acid | For nutritional supplementation and for treating dietary shortage or imbalance. | |
| approved;nutraceutical | DB00159 | Icosapent | "EPA can be used for lowering elevated triglycerides in those who are hyperglyceridemic. In addition, EPA may play a therapeutic role in patients with cystic fibrosis by reducing disease severity and may play a similar role in type 2 diabetics in slowing the progression of diabetic nephropathy." | C10AX06 |