How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: FAS

    Description: "Fas (TNF receptor superfamily, member 6)"

    Entrez Gene ID: 355

    SwissProt Acc Number: P25445

    RefSeq: NM_000043

    It was suspected to be CHD related:

    ..reverse transcription (RT)-PCR and Western blotting analysis demonstrated that levels of Fas and FasL expression were increased in nicotine-treated HUVECs..

    From PMID: 20383341, in Journal Methods Find Exp Clin Pharmacol , 2010


    There were 86 potential papers with FAS and CHD.

    24170655 CHD knowledge and risk factors among Filipino-Americans connected to primary care services.Journal of the American Association of Nurse PractitionersMore Details
    24056314 Erythrocyte membrane fatty acid composition is related to overloaded plasma ferritin in Chinese males with angiographic coronary artery disease.Food & functionMore Details
    23530883 Analytical performance validation of a coronary heart disease risk assessment multi-analyte proteomic test.Expert opinion on medical diagnosticsMore Details
    23628332 Anti-adipogenic activity of compounds isolated from Idesia polycarpa on 3T3-L1 cells.Bioorganic & medicinal chemistry lettersMore Details
    24146100 Study of molecular mechanism of Prostaglandin E1 in inhibiting coronary heart disease.Molecular biology reportsMore Details
    23993643 Assessing Cognitive Effects of Anticholinergic Medications in Patients With Coronary Artery Disease.PsychosomaticsMore Details
    22572621 Effects of fatty acids on endothelial cells: inflammation and monocyte adhesion.The Journal of surgical researchMore Details
    22727498 Effect of folic acid supplementation on plasma total homocysteine levels and glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis.Diabetes research and clinical practiceMore Details
    23092312 Coronary risk assessment among intermediate risk patients using a clinical and biomarker based algorithm developed and validated in two population cohorts.Current medical research and opinionMore Details
    23094958 Production of trans-free margarine with stearidonic acid soybean and high-stearate soybean oils-based structured lipid.Journal of food scienceMore Details
    21775161 Plasma fatty acids in chronic kidney disease: nervonic acid predicts mortality.Journal of renal nutrition : the official journal of the Council on RenalMore Details
    23450131 The Relationship of Serum Soluble Fas Ligand (sFasL) Level with the Extent of Coronary Artery Disease.The International journal of angiology : official publication of theMore Details
    21655933 Aging might increase myocardial ischemia / reperfusion-induced apoptosis in humans and rats."Age (Dordrecht, Netherlands)"More Details
    22019821 In vivo characterization of coronary plaques: novel findings from comparing greyscale and virtual histology intravascular ultrasound and near-infrared spectroscopy.European heart journalMore Details
    23097270 Novel circulating fatty acid patterns and risk of cardiovascular disease: the Cardiovascular Health Study.The American journal of clinical nutritionMore Details
    22471389 Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells.BMC complementary and alternative medicineMore Details
    22221489 Health effects of dietary phospholipids.Lipids in health and diseaseMore Details
    21286777 Genetic polymorphisms of TP53 and FAS promoter modulate the progression of coronary artery disease after coronary artery bypass grafting: a gender-specific view.Inflammation research : official journal of the European Histamine ResearchMore Details
    21359408 High soluble Fas and soluble Fas Ligand serum levels before stent implantation are protective against restenosis.Thrombosis and haemostasisMore Details
    21168312 Granzyme B as a novel factor involved in cardiovascular diseases.Journal of cardiologyMore Details
    20935172 Common CD36 SNPs reduce protein expression and may contribute to a protective atherogenic profile.Human molecular geneticsMore Details
    21422918 Relationship between circulating soluble Fas ligand and preexisting left ventricular hypertrophy in the setting of left ventricular remodeling after acute myocardial infarction.Coronary artery diseaseMore Details
    21112198 The protective effect of peony extract on acute myocardial infarction in rats.Phytomedicine : international journal of phytotherapy and phytopharmacologyMore Details
    21816064 High glucose-induced apoptosis in human coronary artery endothelial cells involves up-regulation of death receptors.Cardiovascular diabetologyMore Details
    21077894 Concept analysis of risk in relation to coronary heart disease among Filipino-Americans.Nursing forumMore Details
    20716712 Effect of omega-3 fatty acids on heart rate variability in depressed patients with coronary heart disease.Psychosomatic medicineMore Details
    20736166 Blocking interferon {beta} stimulates vascular smooth muscle cell proliferation and arteriogenesis.The Journal of biological chemistryMore Details
    20200208 Lysosome-dependent Ca(2+) release response to Fas activation in coronary arterial myocytes through NAADP: evidence from CD38 gene knockouts.American journal of physiology. Cell physiologyMore Details
    19846343 Preprocedural concerns and anxiety assessment in patients undergoing coronary angiography and percutaneous coronary interventions.European journal of cardiovascular nursing : journal of the Working Group onMore Details
    20145438 Omega-6 and omega-3 fatty acids: partners in prevention.Current opinion in clinical nutrition and metabolic careMore Details
    20569715 Heart rate is associated with red blood cell fatty acid concentration: the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study.American heart journalMore Details
    20551373 Blood eicosapentaenoic and docosahexaenoic acids predict all-cause mortality in patients with stable coronary heart disease: the Heart and Soul study.Circulation. Cardiovascular quality and outcomesMore Details
    20462896 Centralized Pan-European survey on the undertreatment of hypercholesterolemia in patients using lipid lowering drugs--the CEPHEUS-Greece survey.AngiologyMore Details
    20383341 Upregulation of Fas and FasL expression in nicotine-induced apoptosis of endothelial cells.Methods and findings in experimental and clinical pharmacologyMore Details
    20102890 Effect of quinapril on in-stent restenosis and relation to plasma apoptosis signaling molecules.The American journal of cardiologyMore Details
    19751413 Macrophage apoptosis in advanced atherosclerosis.Annals of the New York Academy of SciencesMore Details
    19414556 Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis.The Journal of experimental medicineMore Details
    18804984 Relationship between n-3 and n-6 plasma fatty acid levels and insulin resistance in coronary patients with and without metabolic syndrome."Nutrition, metabolism, and cardiovascular diseases : NMCD"More Details
    19151252 Combined therapy with cardioprotective cytokine administration and antiapoptotic gene transfer in postinfarction heart failure.American journal of physiology. Heart and circulatory physiologyMore Details
    19325141 Human placental ectonucleoside triphosphate diphosphohydrolase gene transfer via gelatin-coated stents prevents in-stent thrombosis."Arteriosclerosis, thrombosis, and vascular biology"More Details
    19056552 Alcohol consumption and n-3 polyunsaturated fatty acids in healthy men and women from 3 European populations.The American journal of clinical nutritionMore Details
    19506932 The effect of fatty or lean fish intake on inflammatory gene expression in peripheral blood mononuclear cells of patients with coronary heart disease.European journal of nutritionMore Details
    19654939 Atherosclerotic progression attenuates the expression of Nogo-B in autopsied coronary artery: pathology and virtual histology intravascular ultrasound analysis.Journal of Korean medical scienceMore Details
    19196721 Prognostic value of apoptosis markers in advanced heart failure patients.European heart journalMore Details
    19110364 "The axial distribution of lesion-site atherosclerotic plaque components: an in vivo volumetric intravascular ultrasound radio-frequency analysis of lumen stenosis, necrotic core and vessel remodeling."Ultrasound in medicine & biologyMore Details
    18842751 Acute coronary syndrome patients with depression have low blood cell membrane omega-3 fatty acid levels.Psychosomatic medicineMore Details
    18761720 The relationship of circulating endothelial cells to plasma indices of endothelial damage/dysfunction and apoptosis in acute coronary syndromes: implications for prognosis.Journal of thrombosis and haemostasis : JTHMore Details
    18923250 The role of Fas in the progression of ischemic heart failure: prohypertrophy or proapoptosis.Coronary artery diseaseMore Details
    18342753 Assessment and characterization of time-related differences in plaque composition by intravascular ultrasound-derived radiofrequency analysis in heart transplant recipients.The Journal of heart and lung transplantation : the official publication of theMore Details
    18645486 Beneficial effect of omega-3 fatty acids on sirolimus- or everolimus-induced hypertriglyceridemia in heart transplant recipients.TransplantationMore Details
    18389484 Cardioprotective effects and underlying mechanisms of oxymatrine against Ischemic myocardial injuries of rats.Phytotherapy research : PTRMore Details
    18068523 Erythrocyte and plasma fatty acid profiles in patients with epilepsy: does carbamazepine affect omega-3 fatty acid concentrations?Epilepsy & behavior : E&BMore Details
    19033007 Omega-6 and trans fatty acids in blood cell membranes: a risk factor for acute coronary syndromes?American heart journalMore Details
    18359029 Soluble Fas ligand plasma levels are associated with forearm reactive hyperemia in subjects with coronary artery disease: a novel biomarker of endothelial function?AtherosclerosisMore Details
    18054937 Consumption of omega-3 fatty acids is not associated with a reduction in carotid atherosclerosis: the Genetics of Coronary Artery Disease in Alaska Natives study.AtherosclerosisMore Details
    17875307 EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls.AtherosclerosisMore Details
    17658509 Cytoprotective effect of bis(1-oxy-2-pyridinethiolato)oxovanadiun(IV) on myocardial ischemia/reperfusion injury elicits inhibition of Fas ligand and Bim expression and elevation of FLIP expression.European journal of pharmacologyMore Details
    17644576 Amlodipine inhibits granulation tissue cell apoptosis through reducing calcineurin activity to attenuate postinfarction cardiac remodeling.American journal of physiology. Heart and circulatory physiologyMore Details
    17478148 Relation of omega-3 Fatty Acid intake to other dietary factors known to reduce coronary heart disease risk.The American journal of cardiologyMore Details
    17324586 Omega-3 fatty acids and cardiovascular disease: a case for omega-3 index as a new risk factor.Pharmacological research : the official journal of the Italian PharmacologicalMore Details
    17335850 Vascular risk factors and intensity of cognitive dysfunction in MCI.Journal of the neurological sciencesMore Details
    17291198 The lipoprotein lipase gene serine 447 stop variant influences hypertension-induced left ventricular hypertrophy and risk of coronary heart disease."Clinical science (London, England : 1979)"More Details
    17223410 Blood omega-3 and trans fatty acids in middle-aged acute coronary syndrome patients.The American journal of cardiologyMore Details
    17053166 "Increased soluble Fas plasma levels in subjects at high cardiovascular risk: Atorvastatin on Inflammatory Markers (AIM) study, a substudy of ACTFAST.""Arteriosclerosis, thrombosis, and vascular biology"More Details
    18092236 Cardioprotective role of cardiotrophin-1 gene transfer in a murine model of myocardial infarction."Growth factors (Chur, Switzerland)"More Details
    16735378 The impact of traditional and non-traditional risk factors on coronary calcification in pre-dialysis patients."Nephrology, dialysis, transplantation : official publication of the European"More Details
    17134636 Effects of omega-3 fatty acids on heart rate in cardiac transplant recipients.The American journal of cardiologyMore Details
    16678847 Targeted cardiac expression of soluble Fas prevents the development of heart failure in mice with cardiac-specific expression of MCP-1.Journal of molecular and cellular cardiologyMore Details
    16466728 "Soluble Fas, a mediator of apoptosis, C-reactive protein, and coronary and extracoronary atherosclerosis. The Rotterdam Coronary Calcification Study."AtherosclerosisMore Details
    16685142 "Coronary artery calcification, systemic inflammation markers and mineral metabolism in a peritoneal dialysis population."Nephron. Clinical practiceMore Details
    16081267 Reduction of oxidative stress and apoptosis in hyperlipidemic rabbits by ellagic acid.The Journal of nutritional biochemistryMore Details
    15733070 High-dose glucose-insulin-potassium treatment reduces myocardial apoptosis in patients with acute myocardial infarction.European journal of clinical investigationMore Details
    15828291 Off-pump coronary artery bypass grafting attenuates proinflammatory markers.The Japanese journal of thoracic and cardiovascular surgery : officialMore Details
    16301817 Choline produces cytoprotective effects against ischemic myocardial injuries: evidence for the role of cardiac m3 subtype muscarinic acetylcholine receptors.Cellular physiology and biochemistry : international journal of experimentalMore Details
    15364800 Different quantitative apoptotic traits in coronary atherosclerotic plaques from patients with stable angina pectoris and acute coronary syndromes.CirculationMore Details
    15364862 Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts.CirculationMore Details
    15364863 Overexpression of human copper/zinc superoxide dismutase (SOD1) suppresses ischemia-reperfusion injury and subsequent development of graft coronary artery disease in murine cardiac grafts.CirculationMore Details
    15319365 Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis.FASEB journal : official publication of the Federation of American Societies for More Details
    15148056 "Remodeling of the chronic severely failing ischemic sheep heart after coronary microembolization: functional, energetic, structural, and cellular responses."American journal of physiology. Heart and circulatory physiologyMore Details
    12629330 "Dual response to Fas ligation in human endothelial cells: apoptosis and induction of chemokines, interleukin-8 and monocyte chemoattractant protein-1."Coronary artery diseaseMore Details
    11839072 18F FDG uptake in the large arteries: a correlation study with the atherogenic risk factors.Seminars in nuclear medicineMore Details
    12170032 Alterations in immunocyte tumor necrosis factor receptor and apoptosis in patients with congestive heart failure.Annals of surgeryMore Details
    11779403 Enhancement of Fas ligand-induced inhibition of neointimal formation in rabbit femoral and iliac arteries by coexpression of p35.Human gene therapyMore Details
    11728960 Soluble Fas is a marker of coronary artery disease in patients with end-stage renal disease.American journal of kidney diseases : the official journal of the National KidneyMore Details
    10779546 Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction.Proceedings of the National Academy of Sciences of the United States of AmericaMore Details
    11139364 Expression of inducible nitric oxide synthase and Fas/Fas ligand correlates with the incidence of apoptotic cell death in atheromatous plaques of human coronary arteries.Nitric oxide : biology and chemistry / official journal of the Nitric OxideMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 59 unique genes interacted with FAS. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    BID Co-purification15659383 CHD related
    TNFRSF10B Co-purification15659383 CHD related
    EZR Co-purification15659383|14676203,17159908 No
    FADD Co-purification15659383|11035039 No
    FASLG Co-purification15659383|9126929|9228058 No
    MAPK8 Co-purification15659383 CHD related
    MSN Co-purification15659383 No
    CASP10 Co-purification15659383|9045686|9325248 No
    CASP8 Co-purification15659383|9208847|9325248 CHD related
    RHOA Co-purification15659383 CHD related
    ARHGDIA Co-purification15659383 No
    TNFRSF1A Co-purification15659383 CHD related
    C14orf1 Two-hybrid16169070|16169070 No
    LRIF1 Two-hybrid16169070 No
    EEF1A1 Two-hybrid16169070 No
    CRMP1 Two-hybrid16169070|16169070 No
    FAS Two-hybrid7538908|8940097|7536190,7538908 CHD related
    RIPK1 Two-hybrid7538908 No
    CFLAR Affinity Capture-Western9208847|9325248 No
    PDCD6 Two-hybrid11606059|11606059 No
    UBE2I Affinity Capture-Western9257699|8940097 No
    FAF1 Affinity Capture-Western8524870|10462485|12372427|12702723 No
    NOL3 Phenotypic Suppression9560245 No
    DAXX Reconstituted Complex11483955|11495919|11773067|9215629|9215629|9215629|11003656 No
    FBF1 Two-hybrid10978533 No
    TRAF3 Reconstituted Complex7859281 No
    FAF2 Two-hybrid12372427 No
    MAP3K5 Affinity Capture-Western11495919 CHD related
    TRADD Affinity Capture-Western11035039 No
    Traf1 Affinity Capture-Western11035039 No
    PRAM1 Affinity Capture-Western21803845 No
    CALM1 in vitro;in vivo14594800 No
    MET in vitro;in vivo15911745 No
    PTPN6 in vitro;in vivo11786908 No
    PRKCA in vitro12586732 CHD related
    RAP1A in vivo15207703 No
    APAF1 in vivo9267021 No
    C1orf103 yeast 2-hybrid16169070 No
    SUMO1 Two-hybrid8906799|8906799|11112409|8906799 No
    HIPK3 Affinity Capture-Western11034606|11034606 No
    FAIM2 Affinity Capture-Western10535980|10535980 No
    FYN Affinity Capture-Western8626376|8626376 No
    CASP8AP2 Affinity Capture-Western10235259|10235259 No
    TNFSF13 Reconstituted Complex10706119|10706119 No
    LCK Reconstituted Complex8864141|8864141 No
    BRE Affinity Capture-Western15465831 No
    TNF Affinity Capture-Western12753742 CHD related
    KRIT1 Affinity Capture-Western14594800 No
    UBC Affinity Capture-MS21906983 No
    BMX Affinity Capture-Western15207703 No
    RARA Affinity Capture-Western21803845 No
    PML Affinity Capture-Western21803845 No
    CD47 in vitro15917238 No
    EGFR in vitro;in vivo12586732 CHD related
    ANK3 in vitro;in vivo;yeast 2-hybrid14694156 No
    UBA7 in vitro;yeast 2-hybrid8940097 No
    BTK in vivo9751072 No
    PTPN13 in vitro;in vivo;yeast 2-hybrid9079683,7536343,9835052,12724420 No
    FEM1B in vitro;in vivo;yeast 2-hybrid10542291 No

    Involved FDA drugs

    There was no drug associated with FAS