How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.

How To contact Us

Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

Website using assistance : Leihong Wu (11019004@zju.edu.cn)

Basic Information

Gene Name: FCAR

Description: "Fc fragment of IgA, receptor for"

Entrez Gene ID: 2204

SwissProt Acc Number: P24071

RefSeq: NM_002000

It was supported literatures to be a novel CHD related gene:

.."Because the myeloid IgA Fc receptor encoded by FCAR mediates inflammation, we hypothesized that the FCAR Asp92Asn polymorphism is associated with risk of MI and that this risk would be modified by pravastatin. Carriers of 92Asn had increased risk of MI in CARE and increased odds of CHD in WOSCOPS. "..

From PMID: 17008591, in Journal Arterioscler Thromb Vasc Biol. , 2006

References

There were 1 potential papers with FCAR and CHD.

PMID	Title	Journals	Details
17008591	Asp92Asn polymorphism in the myeloid IgA Fc receptor is associated with myocardial infarction in two disparate populations: CARE and WOSCOPS.	"Arteriosclerosis, thrombosis, and vascular biology"	More Details

NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

PPI interactions

There were totally 7 unique genes interacted with FCAR. Show PPI network

Gene name	Interaction type	reference PMID	CHD relation
LYN	Affinity Capture-Western	9427690	No
CD79A	in vivo	10438530,8666916	No
FCAR	in vitro	12634059,12768205	CHD related
PILRA	in vitro	15085135	No
OSCAR	in vitro	15085135	No
PPP2CA	in vitro;in vivo;yeast 2-hybrid	18768864	CHD related
FCGR1A	Affinity Capture-Western	8530370	No

Involved FDA drugs

There was no drug associated with FCAR

Design by WLH