How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: FCAR

    Description: "Fc fragment of IgA, receptor for"

    Entrez Gene ID: 2204

    SwissProt Acc Number: P24071

    RefSeq: NM_002000

    It was supported literatures to be a novel CHD related gene:

    .."Because the myeloid IgA Fc receptor encoded by FCAR mediates inflammation, we hypothesized that the FCAR Asp92Asn polymorphism is associated with risk of MI and that this risk would be modified by pravastatin. Carriers of 92Asn had increased risk of MI in CARE and increased odds of CHD in WOSCOPS. "..

    From PMID: 17008591, in Journal Arterioscler Thromb Vasc Biol. , 2006


    There were 1 potential papers with FCAR and CHD.

    17008591 Asp92Asn polymorphism in the myeloid IgA Fc receptor is associated with myocardial infarction in two disparate populations: CARE and WOSCOPS."Arteriosclerosis, thrombosis, and vascular biology"More Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 7 unique genes interacted with FCAR. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    LYN Affinity Capture-Western9427690 No
    CD79A in vivo10438530,8666916 No
    FCAR in vitro12634059,12768205 CHD related
    PILRA in vitro15085135 No
    OSCAR in vitro15085135 No
    PPP2CA in vitro;in vivo;yeast 2-hybrid18768864 CHD related
    FCGR1A Affinity Capture-Western8530370 No

    Involved FDA drugs

    There was no drug associated with FCAR