How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
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    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: FGF23

    Description: fibroblast growth factor 23

    Entrez Gene ID: 8074

    SwissProt Acc Number: Q9GZV9

    RefSeq: NM_020638

    It was supported literatures to be a novel CHD related gene:

    .."Previous studies have shown that fibroblast growth factor 23 (FGF23), which has an important role in phosphate metabolism, is elevated in chronic hemodialysis patients."..

    From PMID: 19214027, in Journal Am J Med Sci. , 2009


    There were 17 potential papers with FGF23 and CHD.

    24168888 Fibroblast growth factor 23 (FGF23) gene polymorphism in children with Kawasaki syndrome (KS) and susceptibility to cardiac abnormalities.Italian journal of pediatricsMore Details
    23795812 Relation between fetuin-A levels and fibroblast growth factor 23 with the severity of coronary artery disease measured by SYNTAX scores.The American journal of cardiologyMore Details
    23389416 Fibroblast growth factor 23 is not associated with and does not induce arterial calcification.Kidney internationalMore Details
    21945708 Expression of FGF23/KLOTHO system in human vascular tissue.International journal of cardiologyMore Details
    23735695 FGF23: a mature renal and cardiovascular risk factor?Blood purificationMore Details
    24015259 Circulating fibroblast growth factor 23 is associated with angiographic severity and extent of coronary artery disease.PloS oneMore Details
    22109743 FGF23 is independently associated with vascular calcification but not bone mineral density in patients at various CKD stages.Osteoporosis international : a journal established as result of cooperationMore Details
    22278430 Potential effects of alendronate on fibroblast growth factor 23 levels and effective control of hypercalciuria in an adult with Jansen's metaphyseal chondrodysplasia.The Journal of clinical endocrinology and metabolismMore Details
    22567137 Bone biomarkers help grading severity of coronary calcifications in non dialysis chronic kidney disease patients.PloS oneMore Details
    22854270 Relationship of fibroblast growth factor 23 with left ventricle mass index and coronary calcificaton in chronic renal disease.Kidney & blood pressure researchMore Details
    21873490 Relationship of serum fibroblast growth factor 23 with cardiovascular disease in older community-dwelling women.European journal of endocrinology / European Federation of Endocrine SocietiesMore Details
    21570529 "Plasma fibroblast growth factor 23, parathyroid hormone, phosphorus, and risk of coronary heart disease."American heart journalMore Details
    20689328 "Fibroblast growth factor 23 in hemodialysis patients: effects of phosphate binder, calcitriol and calcium concentration in the dialysate."Nephron. Clinical practiceMore Details
    21660261 Phosphate Metabolism in CKD Stages 3-5: Dietary and Pharmacological Control.International journal of nephrologyMore Details
    20479029 The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the Heart and Soul Study.Annals of internal medicineMore Details
    19214027 Fibroblast growth factor 23: a possible cause of left ventricular hypertrophy in hemodialysis patients.The American journal of the medical sciencesMore Details
    19295197 Dietary and pharmacological control of calcium and phosphate metabolism in predialysis stages of chronic kidney disease.Blood purificationMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 4 unique genes interacted with FGF23. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    FGFR1 Affinity Capture-Western22393163 No
    PHEX in vitro11409890 No
    FGFR3 in vitro12032146 No
    FGFR2 in vitro12032146 No

    Involved FDA drugs

    There was no drug associated with FGF23