Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)
Website using assistance : Leihong Wu (11019004@zju.edu.cn)
Coronary Heart Disease Research Platform
Description: forkhead box O1
This suspected gene is newly curated in the Version 2.0It was suspected to be CHD related:
..In addition, both Foxo1 and Foxo3 are phosphorylated and consequently inactivated in hearts undergoing hypertrophic growth induced by hemodynamic stress...
From PMID: 16952979, in Journal Circulation. 2006;114:1159-1168 ,There were 4 potential papers with FOXO1 and CHD.
| PMID | Title | Journals | Details |
|---|---|---|---|
| 22326951 | Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice. | The Journal of clinical investigation | More Details |
| 19786632 | MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. | Circulation | More Details |
| 19059213 | Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1-FoxO1 pathway. | Biochemical and biophysical research communications | More Details |
| 15824087 | FOXO-dependent expression of the proapoptotic protein Bim: pivotal role for apoptosis signaling in endothelial progenitor cells. | FASEB journal : official publication of the Federation of American Societies for | More Details |
NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.
There were totally 39 unique genes interacted with FOXO1. Show PPI network
| Gene name | Interaction type | reference PMID | CHD relation |
|---|---|---|---|
| CREBBP | Two-hybrid | 10973497|16154098|15220471|15220471 | No |
| YWHAG | Affinity Capture-Western | 11237865 | No |
| YWHAZ | Affinity Capture-Western | 11237865 | No |
| CEBPB | Reconstituted Complex | 11893744 | No |
| HNF4A | Reconstituted Complex | 12519792 | No |
| HOXA11 | Affinity Capture-Western | 19727442 | No |
| SKP2 | Affinity Capture-Western | 15668399 | No |
| PML | Affinity Capture-Western | 16154098 | No |
| SIRT1 | Affinity Capture-Western | 16154098|22013015|15692560 | CHD related |
| SIRT2 | Affinity Capture-Western | 15220471|15220471|20543840 | No |
| ATG7 | Affinity Capture-Western | 20543840 | No |
| MDM2 | Affinity Capture-Western | 19321440 | CHD related |
| RARA | Reconstituted Complex | 11353774|11353774 | No |
| TXNRD1 | Reconstituted Complex | 11353774 | CHD related |
| THRB | in vitro;in vivo | 11353774 | No |
| AR | Affinity Capture-Western | 12482965|12482965|12482965|12482965 | CHD related |
| SMAD3 | Affinity Capture-Western | 15084259|15084259 | CHD related |
| SMAD4 | Affinity Capture-Western | 15084259|15084259 | No |
| SRC | Reconstituted Complex | 10973497|10973497 | CHD related |
| TSC2 | Affinity Capture-Western | 17077083|17077083|17077083 | No |
| ESR1 | Two-hybrid | 11435445|11435445|11353774|22266855 | CHD related |
| HOXA5 | Reconstituted Complex | 12163409|12163409 | No |
| RFWD2 | Affinity Capture-Western | 18815134 | No |
| PARP1 | Affinity Capture-Western | 19281796|19281796 | CHD related |
| LRPPRC | Reconstituted Complex | 17050673 | No |
| UBC | Affinity Capture-Western | 15668399|13679577|19686743 | No |
| AKT1 | Biochemical Activity | 16076959|10358014 | CHD related |
| STUB1 | Affinity Capture-Western | 19483080 | No |
| NLK | Affinity Capture-Western | 20874444 | No |
| FHL2 | in vitro | 15692560 | No |
| CTNNB1 | yeast 2-hybrid | 15905404 | CHD related |
| FOXG1 | in vivo | 15084259 | No |
| PPARG | in vitro;yeast 2-hybrid | 12966085 | CHD related |
| HOXA10 | in vitro | 12493691 | No |
| G6PC | in vitro | 11672436 | No |
| PAK1 | in vivo | 10358014,12560069 | CHD related |
| GSK3B | in vivo | 11980723 | CHD related |
| CSNK1G1 | in vivo | 11980723 | No |
| DYRK1A | in vitro;in vivo | 11311120 | No |
There was no drug associated with FOXO1