How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: FOXP3

    Description: forkhead box P3

    Entrez Gene ID: 50943

    SwissProt Acc Number: Q9BZS1

    RefSeq: NM_001114377

    It was supported literatures to be a novel CHD related gene:

    .."These data indicate that, for the first time, FOXP3 gene polymorphism may appear to play an important role in the susceptibility of ACS in Chinese Han population."..

    From PMID: 23299803, in Journal Cell Biochem Funct , 2013


    References

    There were 18 potential papers with FOXP3 and CHD.

    PMIDTitleJournalsDetails
    23299803 FOXP3 genetic variant and risk of acute coronary syndrome in Chinese Han population.Cell biochemistry and functionMore Details
    23531479 Regulatory T cells contribute to rosuvastatin-induced cardioprotection against ischemia-reperfusion injury.Coronary artery diseaseMore Details
    23566804 Methylation of FOXP3 in regulatory T cells is related to the severity of coronary artery disease.AtherosclerosisMore Details
    23340699 Lack of CD4(+)CD25(+)FOXP3(+) regulatory T cells is associated with resistance to intravenous immunoglobulin therapy in patients with Kawasaki disease.European journal of pediatricsMore Details
    23735638 FOXP3 demethylation as a means of identifying quantitative defects in regulatory T cells in acute coronary syndrome.AtherosclerosisMore Details
    22955109 The role of TGF-beta and myofibroblasts in the arteritis of Kawasaki disease.Human pathologyMore Details
    22628434 Low levels of circulating CD4+FoxP3+ T cells are associated with an increased risk for development of myocardial infarction but not for stroke."Arteriosclerosis, thrombosis, and vascular biology"More Details
    22396788 Lymphocyte subpopulations in lymph nodes and peripheral blood: a comparison between patients with stable angina and acute coronary syndrome.PloS oneMore Details
    21855850 Induced interleukin-19 contributes to cell-mediated immunosuppression in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass.The Annals of thoracic surgeryMore Details
    21297489 Expression of circulatory dendritic cells and regulatory T-cells in patients with different subsets of coronary artery disease.Journal of cardiovascular pharmacologyMore Details
    22084439 Neutralizing IL-6 reduces human arterial allograft rejection by allowing emergence of CD161+ CD4+ regulatory T cells."Journal of immunology (Baltimore, Md. : 1950)"More Details
    21524750 "Activation of Th17/Th1 and Th1, but not Th17, is associated with the acute cardiac event in patients with acute coronary syndrome."AtherosclerosisMore Details
    19923021 Inflammatory characteristics of premature coronary artery disease.International journal of cardiologyMore Details
    19836260 The Th17/Treg functional imbalance during atherogenesis in ApoE(-/-) mice.CytokineMore Details
    18294918 The Th17/Treg imbalance in patients with acute coronary syndrome."Clinical immunology (Orlando, Fla.)"More Details
    17512253 The opposite-direction modulation of CD4+CD25+ Tregs and T helper 1 cells in acute coronary syndromes."Clinical immunology (Orlando, Fla.)"More Details
    16954132 Altered status of CD4(+)CD25(+) regulatory T cells in patients with acute coronary syndromes.European heart journalMore Details
    16682613 Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells.CirculationMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 15 unique genes interacted with FOXP3. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    NFATC2 Co-localization19564342 No
    HDAC9 Affinity Capture-Western17360565 No
    REL Affinity Capture-Luminescence21490927 No
    KAT8 Reconstituted Complex22152480 No
    HIST1H1B Affinity Capture-MS21654845|21654845 No
    RELA Affinity Capture-Western15790681 CHD related
    RUNX1 in vitro;in vivo17377532 CHD related
    KAT5 Affinity Capture-Western17360565 No
    HDAC7 Affinity Capture-Western17360565 No
    HDAC2 Co-localization19276356 CHD related
    HDAC4 Co-localization19276356 CHD related
    IKZF4 Affinity Capture-Western19696312|19696312 No
    NFATC1 Affinity Capture-Luminescence21490927 CHD related
    HDAC1 Affinity Capture-Western21974802 CHD related
    NFAT5 in vivo15790681 No


    Involved FDA drugs

    There was no drug associated with FOXP3