Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)
Website using assistance : Leihong Wu (11019004@zju.edu.cn)
Coronary Heart Disease Research Platform
Description: GATA binding protein 4
Entrez Gene ID: 2626
SwissProt Acc Number: P43694
RefSeq: NM_002052
It was suspected to be CHD related:
.."The transcription factor GATA4 is a critical regulator of cardiac gene expression, modulating cardiomyocyte differentiation and adaptive responses of the adult heart."..
From PMID: 17975667, in Journal J Clin Invest , 2007There were 9 potential papers with GATA4 and CHD.
| PMID | Title | Journals | Details |
|---|---|---|---|
| 23467912 | Cardiomyocyte differentiation of perinatallyderived mesenchymal stem cells. | Molecular medicine reports | More Details |
| 23048191 | Nitric oxide synthase-3 deficiency results in hypoplastic coronary arteries and postnatal myocardial infarction. | European heart journal | More Details |
| 22522929 | In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. | Nature | More Details |
| 22318994 | Human gene copy number spectra analysis in congenital heart malformations. | Physiological genomics | More Details |
| 21077732 | Gene expression profiles following intracoronary injection of mesenchymal stromal cells using a porcine model of chronic myocardial infarction. | Cytotherapy | More Details |
| 19411759 | Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. | The Journal of clinical investigation | More Details |
| 19715896 | Gene expression profiles in a porcine model of infarction: differential expression after intracoronary injection of heterologous bone marrow mesenchymal cells. | Transplantation proceedings | More Details |
| 17975667 | Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. | The Journal of clinical investigation | More Details |
| 15464586 | GATA4 is a dosage-sensitive regulator of cardiac morphogenesis. | Developmental biology | More Details |
NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.
There were totally 29 unique genes interacted with GATA4. Show PPI network
| Gene name | Interaction type | reference PMID | CHD relation |
|---|---|---|---|
| NKX2-5 | Affinity Capture-Western | 12845333|9312027|10948187|10948187|9312027,10948187 | CHD related |
| HAND2 | Reconstituted Complex | 11994297|11994297|11994297 | No |
| ZFPM2 | Two-hybrid | 9927675|9927675|9927675|10801815|9927675,11297508 | No |
| SRF | Affinity Capture-Western | 11003651|11003651,11158291 | CHD related |
| ALX4 | Two-hybrid | 20211142 | No |
| ZBTB3 | Two-hybrid | 20211142 | No |
| SP1 | Affinity Capture-Western | 14988427 | No |
| HDAC2 | Affinity Capture-Western | 20833366 | CHD related |
| EZH2 | Affinity Capture-Western | 22215809 | No |
| EZH1 | Affinity Capture-Western | 22215809 | No |
| SUZ12 | Affinity Capture-Western | 22215809 | No |
| JARID2 | Affinity Capture-Western | 22215809|15542826 | No |
| MEF2C | in vitro;in vivo | 10790371 | No |
| CRIP2 | in vitro;in vivo | 12530967 | No |
| MAPK3 | in vitro | 11585926 | CHD related |
| MED1 | in vitro | 11724781 | No |
| FOS | in vitro | 9207128 | CHD related |
| MDC1 | Protein-peptide | 14578343 | No |
| TBX5 | Affinity Capture-Western | 12845333 | No |
| NR5A1 | Reconstituted Complex | 10446911 | No |
| MAPK1 | Biochemical Activity | 11585926 | CHD related |
| ID1 | Affinity Capture-Western | 16556596|16556596 | No |
| ID2 | Affinity Capture-Western | 16556596|16556596 | No |
| ID3 | Affinity Capture-Western | 16556596|16556596 | No |
| EP300 | Affinity Capture-Western | 18252717 | CHD related |
| Cdk9 | Affinity Capture-Western | 20081228|20081228 | No |
| KDM6A | Affinity Capture-Western | 22192413 | No |
| NFATC4 | in vitro;in vivo;yeast 2-hybrid | 9568714 | No |
| PIAS1 | in vitro | 15337742 | No |
There was no drug associated with GATA4