How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: GCLC

    Description: "glutamate-cysteine ligase, catalytic subunit"

    Entrez Gene ID: 2729

    SwissProt Acc Number: P48506

    RefSeq: NM_001498

    It was suspected to be CHD related:

    ..The GCLC C-129T polymorphism may be one of the genetic risk factor while the GCLM G-23T polymorphism may be one of the genetic protective factors for CHD in this Chinese population...

    From PMID: 17961430, in Journal Zhonghua Xin Xue Guan Bing Za Zhi , 2007


    References

    There were 1 potential papers with GCLC and CHD.

    PMIDTitleJournalsDetails
    22824862 Glutathione (GSH) and the GSH synthesis gene Gclm modulate vascular reactivity in mice.Free radical biology & medicineMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 2 unique genes interacted with GCLC. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    UBC Affinity Capture-MS21139048|21906983 No
    ELAVL1 Affinity Capture-RNA19322201 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approved;nutraceuticalDB00142L-Glutamic Acid"Considered to be nature's ""Brain food"" by improving mental capacities; helps speed the healing of ulcers; gives a ""lift"" from fatigue; helps control alcoholism, schizophrenia and the craving for sugar."A09AB01
    approved;nutraceuticalDB00151L-CysteineFor the prevention of liver damage and kidney damage associated with overdoses of acetaminophenR05CB01;S01XA08;V03AB23