How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
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    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: GH1

    Description: growth hormone 1

    Entrez Gene ID: 2688

    SwissProt Acc Number: P01241

    RefSeq: NM_000515

    It was suspected to be CHD related:

    .."In conclusion, genetic polymorphisms in the GHR gene and its ligand, GH1, may modulate the risk of CAD in the Asian Indian population."..

    From PMID: 21273694, in Journal J Genet. , 2010


    There were 0 potential papers with GH1 and CHD.

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 7 unique genes interacted with GH1. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    LTA4H Affinity Capture-MS17353931 CHD related
    STRAP Affinity Capture-MS17353931 No
    GHR Reconstituted Complex7862673|17500058 CHD related
    SHC1 Biochemical Activity7535773 No
    BTRC Reconstituted Complex17500058 No
    GH1 in vitro15741328 CHD related
    PRLR in vitro9556914 No

    Involved FDA drugs

    There was no drug associated with GH1