How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
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    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: GJA4

    Description: "gap junction protein, alpha 4, 37kDa"

    Entrez Gene ID: 2701

    SwissProt Acc Number: P35212

    RefSeq: NM_002060

    It was suspected to be CHD related:

    ..Connexin37 (GJA4) genotype predicts survival after an acute coronary syndrome...

    From PMID: 17719307, in Journal Am Heart J.? , 2007


    There were 2 potential papers with GJA4 and CHD.

    18073482 Association of connexin 37 gene polymorphisms with risk of coronary artery disease in northern Han Chinese.CardiologyMore Details
    17719307 Connexin37 (GJA4) genotype predicts survival after an acute coronary syndrome.American heart journalMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There was NO PPI interaction information about GJA4

    Involved FDA drugs

    There was no drug associated with GJA4