How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: GPER

    Description: G protein-coupled estrogen receptor 1

    Entrez Gene ID: 2852

    SwissProt Acc Number: Q99527

    RefSeq: NM_001039966

    It was supported literatures to be a novel CHD related gene:

    .."With accumulating evidence that GPER is responsible for a variety of beneficial cardiovascular effects of estrogens, this receptor may represent a novel target to develop effective strategies for the treatment of cardiovascular diseases by tissue-specific, selective activation of estrogen-dependent molecular pathways devoid of side effects seen with conventional hormone therapy."..

    From PMID: 21742056, in Journal Vascul Pharmacol. , 2011


    References

    There were 4 potential papers with GPER and CHD.

    PMIDTitleJournalsDetails
    23615160 Alike but not the same: anatomic heterogeneity of estrogen receptor-mediated vasodilation.Journal of cardiovascular pharmacologyMore Details
    21281456 "Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors.""Acta physiologica (Oxford, England)"More Details
    21742056 The G protein-coupled estrogen receptor GPER/GPR30 as a regulator of cardiovascular function.Vascular pharmacologyMore Details
    20639684 "Dilation of epicardial coronary arteries by the G protein-coupled estrogen receptor agonists G-1 and ICI 182,780."PharmacologyMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There was NO PPI interaction information about GPER



    Involved FDA drugs

    There was no drug associated with GPER