How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: GPT

    Description: glutamic-pyruvate transaminase (alanine aminotransferase)

    Entrez Gene ID: 2875

    SwissProt Acc Number: P24298

    RefSeq: NM_005309

    It was supported literatures to be a novel CHD related gene:

    .."The finding of released GOT, GPT, ALP, acid maltase and alpha-HBDH in groups IA and IB is an indication of early myocardial damage in chronic chagasic patients without clinical evidence of cardiac disease."..

    From PMID: 12658870, in Journal Acta Cient Venez , 2002


    References

    There were 3 potential papers with GPT and CHD.

    PMIDTitleJournalsDetails
    22792043 Sonographic gallbladder abnormality is associated with intravenous immunoglobulin resistance in Kawasaki disease.TheScientificWorldJournalMore Details
    19784582 Alteration of sphingolipid metabolism and pSTAT3 expression by dietary cholesterol in the gallbladder of hamsters.Archives of pharmacal researchMore Details
    19322022 A reconstituted HDL containing V156K or R173C apoA-I exhibited anti-inflammatory activity in apo-E deficient mice and showed resistance to myeloperoxidase-mediated oxidation.Experimental & molecular medicineMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 1 unique genes interacted with GPT. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    CAPN1 yeast 2-hybrid12358155 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    nutraceuticalDB00114Pyridoxal PhosphateFor nutritional supplementation and for treating dietary shortage or imbalance.A11HA02;A11HA06
    approved;nutraceuticalDB00142L-Glutamic Acid"Considered to be nature's ""Brain food"" by improving mental capacities; helps speed the healing of ulcers; gives a ""lift"" from fatigue; helps control alcoholism, schizophrenia and the craving for sugar."A09AB01
    approved;nutraceuticalDB00160L-AlanineUsed for protein synthesis.
    approvedDB00780PhenelzineFor the treatment of major depressive disorder. Has also been used with some success in the management of bulimia nervosa.N06AF03