How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: GRK5

    Description: G protein-coupled receptor kinase 5

    Entrez Gene ID: 2869

    SwissProt Acc Number: P34947

    RefSeq: NM_005308

    It was supported literatures to be a novel CHD related gene:

    .."Taken together, increased GRK5 may regulate AT1R expression in CHF, and ExT mitigates AT1R and its pathway components."..

    From PMID: 22753221, in Journal Hypertension. , 2012


    References

    There were 1 potential papers with GRK5 and CHD.

    PMIDTitleJournalsDetails
    22753221 Parallel changes in neuronal AT1R and GRK5 expression following exercise training in heart failure.HypertensionMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 176 unique genes interacted with GRK5. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    AVPR1A Affinity Capture-Western10858434|10858434 CHD related
    AVPR2 Affinity Capture-Western10858434|10858434 No
    OXTR Affinity Capture-Western10858434 No
    TACR1 Biochemical Activity12067742|12067742 No
    SNCA Biochemical Activity10852916|10852916|10617630,10852916 No
    SNCB Biochemical Activity10852916|10852916 No
    SNCG Biochemical Activity10852916|10852916 No
    GRK5 Biochemical Activity8144599|8144599 CHD related
    RHO Biochemical Activity8144599|8288567,8144599 No
    SRRM2 Affinity Capture-MS22952844 No
    FRYL Affinity Capture-MS22952844 No
    SPTAN1 Affinity Capture-MS22952844 No
    MYH9 Affinity Capture-MS22952844 No
    MYH10 Affinity Capture-MS22952844 No
    SPTBN1 Affinity Capture-MS22952844 No
    CKAP5 Affinity Capture-MS22952844 No
    NCL Affinity Capture-MS22952844 No
    DDB1 Affinity Capture-MS22952844|22952844 No
    AP3D1 Affinity Capture-MS22952844 No
    OTUD4 Affinity Capture-MS22952844 No
    CWC22 Affinity Capture-MS22952844 No
    HSP90AB1 Affinity Capture-MS22952844 CHD related
    HSP90AA1 Affinity Capture-MS22952844 CHD related
    UBTF Affinity Capture-MS22952844 No
    PNN Affinity Capture-MS22952844 No
    DHX9 Affinity Capture-MS22952844 No
    AFF4 Affinity Capture-MS22952844 No
    DCAF5 Affinity Capture-MS22952844 No
    HNRNPU Affinity Capture-MS22952844 No
    KPNB1 Affinity Capture-MS22952844 No
    DHX30 Affinity Capture-MS22952844 No
    CUL4B Affinity Capture-MS22952844|22952844 No
    EIF3A Affinity Capture-MS22952844 No
    GYS1 Affinity Capture-MS22952844 No
    KANK2 Affinity Capture-MS22952844 No
    NAT10 Affinity Capture-MS22952844 No
    MMS19 Affinity Capture-MS22952844 No
    DHX15 Affinity Capture-MS22952844 No
    PPIG Affinity Capture-MS22952844 No
    ILF3 Affinity Capture-MS22952844 No
    AP2A1 Affinity Capture-MS22952844 No
    MYO1C Affinity Capture-MS22952844 No
    SRPK1 Affinity Capture-MS22952844 No
    ACIN1 Affinity Capture-MS22952844 No
    EEF2 Affinity Capture-MS22952844 No
    HDAC6 Affinity Capture-MS22952844 No
    USP15 Affinity Capture-MS22952844 No
    HSPA4 Affinity Capture-MS22952844 No
    PSMD2 Affinity Capture-MS22952844 No
    CAND2 Affinity Capture-MS22952844 No
    FTSJ3 Affinity Capture-MS22952844 No
    TCOF1 Affinity Capture-MS22952844 No
    KANK1 Affinity Capture-MS22952844 No
    GLG1 Affinity Capture-MS22952844 No
    EFTUD2 Affinity Capture-MS22952844 No
    MAP4 Affinity Capture-MS22952844 No
    PPP6R3 Affinity Capture-MS22952844 No
    BCLAF1 Affinity Capture-MS22952844 No
    GEMIN4 Affinity Capture-MS22952844 No
    ABCF1 Affinity Capture-MS22952844 No
    XRCC5 Affinity Capture-MS22952844 No
    SIN3A Affinity Capture-MS22952844 No
    MADD Affinity Capture-MS22952844 No
    ANKFY1 Affinity Capture-MS22952844 No
    STK38 Affinity Capture-MS22952844 No
    TAB1 Affinity Capture-MS22952844 No
    GRWD1 Affinity Capture-MS22952844 No
    AKT2 Affinity Capture-MS22952844 CHD related
    PSMC1 Affinity Capture-MS22952844 No
    GOT1L1 Affinity Capture-MS22952844 No
    DLST Affinity Capture-MS22952844 No
    MYCN Affinity Capture-MS22952844 No
    CALR Affinity Capture-MS22952844 No
    SPIN1 Affinity Capture-MS22952844 No
    GINS4 Affinity Capture-MS22952844 No
    THOC4 Affinity Capture-MS22952844 No
    COPS7A Affinity Capture-MS22952844 No
    YWHAG Affinity Capture-MS22952844 No
    CLIC1 Affinity Capture-MS22952844 No
    SAP18 Affinity Capture-MS22952844 No
    LYZ Affinity Capture-MS22952844 No
    ARF1 Affinity Capture-MS22952844 No
    PRKDC Affinity Capture-MS22952844 No
    MYO9B Affinity Capture-MS22952844 No
    DOCK4 Affinity Capture-MS22952844 No
    USP9X Affinity Capture-MS22952844 No
    AP3B1 Affinity Capture-MS22952844 No
    NOLC1 Affinity Capture-MS22952844 No
    LRPPRC Affinity Capture-MS22952844 No
    BAZ1A Affinity Capture-MS22952844 No
    UBE2O Affinity Capture-MS22952844 No
    NCBP1 Affinity Capture-MS22952844 No
    JUP Affinity Capture-MS22952844 CHD related
    RAB11FIP5 Affinity Capture-MS22952844 No
    FAM120A Affinity Capture-MS22952844 No
    DDX21 Affinity Capture-MS22952844 No
    BCR Affinity Capture-MS22952844 CHD related
    FMNL2 Affinity Capture-MS22952844 No
    PNPLA6 Affinity Capture-MS22952844 No
    RANBP9 Affinity Capture-MS22952844 No
    LARP1 Affinity Capture-MS22952844 No
    SRRM1 Affinity Capture-MS22952844 No
    ABI3BP Affinity Capture-MS22952844 No
    U2SURP Affinity Capture-MS22952844 No
    SKIV2L2 Affinity Capture-MS22952844 No
    SMARCA1 Affinity Capture-MS22952844 No
    AP2A2 Affinity Capture-MS22952844 No
    CTDP1 Affinity Capture-MS22952844 CHD related
    MAP4K4 Affinity Capture-MS22952844 CHD related
    PPFIBP1 Affinity Capture-MS22952844 No
    MYBBP1A Affinity Capture-MS22952844 No
    BMS1 Affinity Capture-MS22952844 No
    DAXX Affinity Capture-MS22952844 No
    USP47 Affinity Capture-MS22952844 No
    FAM75A7 Affinity Capture-MS22952844 No
    RPL4 Affinity Capture-MS22952844 No
    AP3M1 Affinity Capture-MS22952844 No
    RPL3 Affinity Capture-MS22952844 No
    PPP2R2A Affinity Capture-MS22952844 No
    EEF1A1 Affinity Capture-MS22952844 No
    EIF4A3 Affinity Capture-MS22952844 No
    COPS4 Affinity Capture-MS22952844 No
    OLA1 Affinity Capture-MS22952844 No
    HADHB Affinity Capture-MS22952844 No
    CDC37 Affinity Capture-MS22952844 No
    LYAR Affinity Capture-MS22952844 No
    COPS2 Affinity Capture-MS22952844 No
    EIF2S3 Affinity Capture-MS22952844 No
    MAEA Affinity Capture-MS22952844 No
    PSMD11 Affinity Capture-MS22952844 No
    AP3M2 Affinity Capture-MS22952844 No
    WDR12 Affinity Capture-MS22952844 No
    PIP4K2A Affinity Capture-MS22952844 No
    NR2F1 Affinity Capture-MS22952844 No
    PSMC6 Affinity Capture-MS22952844 No
    C9orf167 Affinity Capture-MS22952844 No
    RBMS1 Affinity Capture-MS22952844 No
    MRPS27 Affinity Capture-MS22952844 No
    KCMF1 Affinity Capture-MS22952844 No
    NAF1 Affinity Capture-MS22952844 No
    MAT2A Affinity Capture-MS22952844 No
    PSMC2 Affinity Capture-MS22952844 No
    TBL2 Affinity Capture-MS22952844 No
    NFIB Affinity Capture-MS22952844 No
    TUFM Affinity Capture-MS22952844 No
    RUVBL1 Affinity Capture-MS22952844 No
    YWHAQ Affinity Capture-MS22952844 No
    YWHAZ Affinity Capture-MS22952844 No
    SRSF1 Affinity Capture-MS22952844 No
    YWHAB Affinity Capture-MS22952844 No
    KCTD5 Affinity Capture-MS22952844 No
    C1QBP Affinity Capture-MS22952844 No
    MRTO4 Affinity Capture-MS22952844 No
    SPIN3 Affinity Capture-MS22952844 No
    WDR82 Affinity Capture-MS22952844 No
    CFL1 Affinity Capture-MS22952844 No
    ARF4 Affinity Capture-MS22952844 No
    SKP1 Affinity Capture-MS22952844 No
    PIP Affinity Capture-MS22952844 No
    TNFAIP8L1 Affinity Capture-MS22952844 No
    CUL4A Affinity Capture-Western22952844 No
    DDB2 Affinity Capture-Western22952844 No
    RBX1 Affinity Capture-Western22952844 No
    UBC Affinity Capture-Western22952844 No
    TBXA2R in vitro;in vivo11504827 CHD related
    AVPR1B in vitro;in vivo10858434 No
    ADRB2 in vitro8662852 CHD related
    BDKRB2 in vitro;in vivo11517230 CHD related
    CHRM2 in vitro8288567 No
    CALM1 Reconstituted Complex9092566 No
    CAV1 Reconstituted Complex10085129|10085129 CHD related
    AGTR1 Affinity Capture-Western9211925|8662816 CHD related
    RCVRN Affinity Capture-Western12507501 No
    CABP1 Reconstituted Complex10625670 No
    GIT1 in vivo9826657 CHD related
    DLGAP2 in vitro11700307 No


    Involved FDA drugs

    There was no drug associated with GRK5