Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)
Website using assistance : Leihong Wu (11019004@zju.edu.cn)
Coronary Heart Disease Research Platform
Description: glutathione S-transferase mu 1
Entrez Gene ID: 2944
SwissProt Acc Number: P09488
RefSeq: NM_000561
It was suspected to be CHD related:
.."These data suggest that polymorphisms in GSTM1 and GSTT1 genes are risk factors for CAD in Type 2 diabetic patients, especially among smokers"..
From PMID: 19102712, in Journal Pharmacogenomics , 2009There were 24 potential papers with GSTM1 and CHD.
| PMID | Title | Journals | Details |
|---|---|---|---|
| 23570881 | "GSTM1, GSTT1, GSTP1, and GSTA1 genetic variants are not associated with coronary artery disease in Taiwan." | Gene | More Details |
| 23275234 | Glutathione S-transferase M1 and T1 genotypes and myocardial infarction. | Molecular biology reports | More Details |
| 22858312 | Association of manganese superoxide dismutase and glutathione S-transferases genotypes with myocardial infarction in patients with type 2 diabetes mellitus. | Diabetes research and clinical practice | More Details |
| 21848428 | "Impact of genetic variations of the CYP1A1, GSTT1, and GSTM1 genes on the risk of coronary artery disease." | DNA and cell biology | More Details |
| 22363809 | Monocyte gene expression signature of patients with early onset coronary artery disease. | PloS one | More Details |
| 20093049 | DNA repair gene polymorphism is associated with the genetic basis of atherosclerotic coronary artery disease. | Cardiovascular pathology : the official journal of the Society for Cardiovascular | More Details |
| 21499713 | "The association between GSTT1, M1, and P1 polymorphisms with coronary artery disease in Western Iran." | Molecular and cellular biochemistry | More Details |
| 21352813 | "Potential risk modifications of GSTT1, GSTM1 and GSTP1 (glutathione-S-transferases) variants and their association to CAD in patients with type-2 diabetes." | Biochemical and biophysical research communications | More Details |
| 21389716 | Glutathione S-transferase gene polymorphism as a susceptibility factor for acute myocardial infarction and smoking in the North Indian population. | Cardiology | More Details |
| 20354063 | "Genetic polymorphisms of glutathione S-transferase genes GSTM1, GSTT1 and risk of coronary heart disease." | Mutagenesis | More Details |
| 19823950 | The common variant in the GSTM1 and GSTT1 genes is related to markers of oxidative stress and inflammation in patients with coronary artery disease: a case-only study. | Molecular biology reports | More Details |
| 19662515 | Influence of genetic polymorphisms of glutathione S-transferase T1 (GSTT1) and M1 (GSTM1) on hematological parameters. | Molecular biology reports | More Details |
| 19419718 | Association between glutathione S-transferase polymorphisms and triglycerides and HDL-cholesterol. | Atherosclerosis | More Details |
| 19102712 | Glutathione S-transferase T1- and M1-null genotypes and coronary artery disease risk in patients with Type 2 diabetes mellitus. | Pharmacogenomics | More Details |
| 18037339 | Genetic polymorphisms and micronucleus formation: a review of the literature. | Mutation research | More Details |
| 18583868 | Impact of glutathione S-transferase M1 and T1 gene polymorphisms on the smoking-related coronary artery disease. | Journal of Korean medical science | More Details |
| 19055448 | Association of GSTM1 and GSTT1 gene polymorphisms with coronary artery disease in relation to tobacco smoking. | Clinical chemistry and laboratory medicine : CCLM / FESCC | More Details |
| 17408703 | "GSTM1, GSTT1 and CYP1A1 detoxification gene polymorphisms and susceptibility to smoking-related coronary artery disease: a case-only study." | Mutation research | More Details |
| 16002077 | A common variant in the glutathione S transferase gene is associated with elevated markers of inflammation and lipid peroxidation in subjects with diabetes mellitus. | Atherosclerosis | More Details |
| 16620396 | T null and M null genotypes of the glutathione S-transferase gene are risk factor for CAD independent of smoking. | BMC medical genetics | More Details |
| 15696395 | Smoking-gene interaction and disease development: relevance to pancreatic cancer and atherosclerosis. | World journal of surgery | More Details |
| 15088107 | Glutathione S-transferase gene polymorphism as a susceptibility factor in smoking-related coronary artery disease. | Basic research in cardiology | More Details |
| 12519635 | Association between the risk of coronary artery disease in South Asians and a deletion polymorphism in glutathione S-transferase M1. | "Biomarkers : biochemical indicators of exposure, response, and susceptibility to " | More Details |
| 12811412 | Interactive effect of the glutathione S-transferase genes and cigarette smoking on occurrence and severity of coronary artery risk. | "Journal of molecular medicine (Berlin, Germany)" | More Details |
NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.
There were totally 4 unique genes interacted with GSTM1. Show PPI network
| Gene name | Interaction type | reference PMID | CHD relation |
|---|---|---|---|
| MAP3K5 | Affinity Capture-Western | 12077134 | CHD related |
| GSTM1 | in vitro | 1530570 | CHD related |
| GSTM2 | Reconstituted Complex | 12192076|6500576,12192076 | No |
| UBC | Affinity Capture-MS | 21906983 | No |
| Status | DrubBank ID | Name | Indication | ATC Code |
|---|---|---|---|---|
| approved;nutraceutical | DB00143 | Glutathione | "For nutritional supplementation, also for treating dietary shortage or imbalance" | V03AB32 |
| experimental | DB01834 | "(9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene" | ||
| experimental | DB02165 | Zinc Trihydroxide | ||
| experimental | DB02458 | "Glutathione S-(2,4 Dinitrobenzene)" | ||
| experimental | DB03314 | Fluorotryptophane | ||
| experimental | DB04187 | "(9s,10s)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene" |