How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: GSTM1

    Description: glutathione S-transferase mu 1

    Entrez Gene ID: 2944

    SwissProt Acc Number: P09488

    RefSeq: NM_000561

    It was suspected to be CHD related:

    .."These data suggest that polymorphisms in GSTM1 and GSTT1 genes are risk factors for CAD in Type 2 diabetic patients, especially among smokers"..

    From PMID: 19102712, in Journal Pharmacogenomics , 2009


    There were 24 potential papers with GSTM1 and CHD.

    23570881 "GSTM1, GSTT1, GSTP1, and GSTA1 genetic variants are not associated with coronary artery disease in Taiwan."GeneMore Details
    23275234 Glutathione S-transferase M1 and T1 genotypes and myocardial infarction.Molecular biology reportsMore Details
    22858312 Association of manganese superoxide dismutase and glutathione S-transferases genotypes with myocardial infarction in patients with type 2 diabetes mellitus.Diabetes research and clinical practiceMore Details
    21848428 "Impact of genetic variations of the CYP1A1, GSTT1, and GSTM1 genes on the risk of coronary artery disease."DNA and cell biologyMore Details
    22363809 Monocyte gene expression signature of patients with early onset coronary artery disease.PloS oneMore Details
    20093049 DNA repair gene polymorphism is associated with the genetic basis of atherosclerotic coronary artery disease.Cardiovascular pathology : the official journal of the Society for CardiovascularMore Details
    21499713 "The association between GSTT1, M1, and P1 polymorphisms with coronary artery disease in Western Iran."Molecular and cellular biochemistryMore Details
    21352813 "Potential risk modifications of GSTT1, GSTM1 and GSTP1 (glutathione-S-transferases) variants and their association to CAD in patients with type-2 diabetes."Biochemical and biophysical research communicationsMore Details
    21389716 Glutathione S-transferase gene polymorphism as a susceptibility factor for acute myocardial infarction and smoking in the North Indian population.CardiologyMore Details
    20354063 "Genetic polymorphisms of glutathione S-transferase genes GSTM1, GSTT1 and risk of coronary heart disease."MutagenesisMore Details
    19823950 The common variant in the GSTM1 and GSTT1 genes is related to markers of oxidative stress and inflammation in patients with coronary artery disease: a case-only study.Molecular biology reportsMore Details
    19662515 Influence of genetic polymorphisms of glutathione S-transferase T1 (GSTT1) and M1 (GSTM1) on hematological parameters.Molecular biology reportsMore Details
    19419718 Association between glutathione S-transferase polymorphisms and triglycerides and HDL-cholesterol.AtherosclerosisMore Details
    19102712 Glutathione S-transferase T1- and M1-null genotypes and coronary artery disease risk in patients with Type 2 diabetes mellitus.PharmacogenomicsMore Details
    18037339 Genetic polymorphisms and micronucleus formation: a review of the literature.Mutation researchMore Details
    18583868 Impact of glutathione S-transferase M1 and T1 gene polymorphisms on the smoking-related coronary artery disease.Journal of Korean medical scienceMore Details
    19055448 Association of GSTM1 and GSTT1 gene polymorphisms with coronary artery disease in relation to tobacco smoking.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    17408703 "GSTM1, GSTT1 and CYP1A1 detoxification gene polymorphisms and susceptibility to smoking-related coronary artery disease: a case-only study."Mutation researchMore Details
    16002077 A common variant in the glutathione S transferase gene is associated with elevated markers of inflammation and lipid peroxidation in subjects with diabetes mellitus.AtherosclerosisMore Details
    16620396 T null and M null genotypes of the glutathione S-transferase gene are risk factor for CAD independent of smoking.BMC medical geneticsMore Details
    15696395 Smoking-gene interaction and disease development: relevance to pancreatic cancer and atherosclerosis.World journal of surgeryMore Details
    15088107 Glutathione S-transferase gene polymorphism as a susceptibility factor in smoking-related coronary artery disease.Basic research in cardiologyMore Details
    12519635 Association between the risk of coronary artery disease in South Asians and a deletion polymorphism in glutathione S-transferase M1."Biomarkers : biochemical indicators of exposure, response, and susceptibility to "More Details
    12811412 Interactive effect of the glutathione S-transferase genes and cigarette smoking on occurrence and severity of coronary artery risk."Journal of molecular medicine (Berlin, Germany)"More Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 4 unique genes interacted with GSTM1. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    MAP3K5 Affinity Capture-Western12077134 CHD related
    GSTM1 in vitro1530570 CHD related
    GSTM2 Reconstituted Complex12192076|6500576,12192076 No
    UBC Affinity Capture-MS21906983 No

    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    approved;nutraceuticalDB00143Glutathione"For nutritional supplementation, also for treating dietary shortage or imbalance"V03AB32
    experimentalDB02165Zinc Trihydroxide
    experimentalDB02458"Glutathione S-(2,4 Dinitrobenzene)"