How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
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    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: HAS2

    Description: hyaluronan synthase 2

    Entrez Gene ID: 3037

    SwissProt Acc Number: Q92819

    RefSeq: NM_005328

    It was supported literatures to be a novel CHD related gene:

    ..The up-regulation of both HAS1 and HAS2 indicates the importance of HA production in the hypertrophic process and the possibility that HA is needed for two different purposes for the heart to be able to adapt to the increased afterload caused by aortic ligature...

    From PMID: 18196277, in Journal Cell Tissue Res , 2009


    There were 1 potential papers with HAS2 and CHD.

    18196276 Parallel up-regulation of FGF-2 and hyaluronan during development of cardiac hypertrophy in rat.Cell and tissue researchMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 3 unique genes interacted with HAS2. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    HAS2 Affinity Capture-Western20507985 CHD related
    HAS3 Affinity Capture-Western20507985 No
    UBC Affinity Capture-MS20507985|20507985 No

    Involved FDA drugs

    There was no drug associated with HAS2