How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (

    Website using assistance : Leihong Wu (

    Basic Information

    Gene Name: HGF

    Description: hepatocyte growth factor (hepapoietin A

    Entrez Gene ID: 3082

    SwissProt Acc Number: P14210

    RefSeq: NM_000601

    It was suspected to be CHD related:

    ..hepatocyte growth factor gene transfer can attenuate radiation-induced cardiac injury and can preserve cardiac function...

    From PMID: 19931736, in Journal Int J Radiat Oncol Biol Phys , 2009


    There were 36 potential papers with HGF and CHD.

    23879535 Number and function impairment of resident C-Kit+ cardiac stem cells in mice with renal dysfunction caused by 5/6 nephrectomy.Renal failureMore Details
    23530883 Analytical performance validation of a coronary heart disease risk assessment multi-analyte proteomic test.Expert opinion on medical diagnosticsMore Details
    23324130 Integrative pathway dissection of molecular mechanisms of moxLDL-induced vascular smooth muscle phenotype transformation.BMC cardiovascular disordersMore Details
    23301013 Catheter-based intramyocardial delivery (NavX) of adenovirus achieves safe and accurate gene transfer in pigs.PloS oneMore Details
    22592978 Effects of hepatocyte growth factor overexpressed bone marrow-derived mesenchymal stem cells on prevention from left ventricular remodelling and functional improvement in infarcted rat hearts.Cell biochemistry and functionMore Details
    23092312 Coronary risk assessment among intermediate risk patients using a clinical and biomarker based algorithm developed and validated in two population cohorts.Current medical research and opinionMore Details
    22392903 Hepatocyte growth factor reduces cardiac fibrosis by inhibiting endothelial-mesenchymal transition.HypertensionMore Details
    21688013 A novel method of augmenting gene expression and angiogenesis in the normal and ischemic canine myocardium.Heart and vesselsMore Details
    21643812 "Prospective, randomized, single-blind comparison of effects of 6 months' treatment with atorvastatin versus pravastatin on leptin and angiogenic factors in patients with coronary artery disease."Heart and vesselsMore Details
    22038108 Effects of erythropoietin on angiogenesis after myocardial infarction in porcine.Heart and vesselsMore Details
    21918549 Long-term effects of hepatocyte growth factor gene therapy in rat myocardial infarct model.Gene therapyMore Details
    22305117 Adipose stromal vascular fraction improves cardiac function in chronic myocardial infarction through differentiation and paracrine activity.Cell transplantationMore Details
    21193434 Hepatocyte growth factor mobilizes non-bone marrow-derived circulating mesoangioblasts.European heart journalMore Details
    20978019 CDKN2BAS is associated with periodontitis in different European populations and is activated by bacterial infection.Journal of medical geneticsMore Details
    21723061 Endogenous cardiac stem cell activation by insulin-like growth factor-1/hepatocyte growth factor intracoronary injection fosters survival and regeneration of the infarcted pig heart.Journal of the American College of CardiologyMore Details
    21541335 hHGF overexpression in myoblast sheets enhances their angiogenic potential in rat chronic heart failure.PloS oneMore Details
    20665672 Chondro/osteoblastic and cardiovascular gene modulation in human artery smooth muscle cells that calcify in the presence of phosphate and calcitriol or paricalcitol.Journal of cellular biochemistryMore Details
    19685158 Hepatocyte growth factor protects endothelial progenitor cell from damage of low-density lipoprotein cholesterol via the PI3K/Akt signaling pathway.Molecular biology reportsMore Details
    18649012 Phase I clinical trial on intracoronary administration of Ad-hHGF treating severe coronary artery disease.Molecular biology reportsMore Details
    19931736 Effects of adenovirus-mediated delivery of the human hepatocyte growth factor gene in experimental radiation-induced heart disease."International journal of radiation oncology, biology, physics"More Details
    19577663 Transfection of HGF gene enhances endothelial progenitor cell (EPC) function and improves EPC transplant efficiency for balloon-induced arterial injury in hypercholesterolemic rats.Vascular pharmacologyMore Details
    19215239 Hepatocyte growth factor plays a critical role in the regulation of cytokine production and induction of endothelial progenitor cell mobilization: a pilot gene therapy study in patients with coronary heart disease.Clinical and experimental pharmacology & physiologyMore Details
    19479183 Enhanced mobilization of CD34(+) progenitor cells expressing cell adhesion molecules in patients with STEMI.Clinical research in cardiology : official journal of the German Cardiac SocietyMore Details
    18068622 In vivo hepatocyte growth factor gene transfer reduces myocardial ischemia-reperfusion injury through its multiple actions.Journal of cardiac failureMore Details
    17973092 Recruitment of stem cells by hepatocyte growth factor via intracoronary gene transfection in the postinfarction heart failure."Science in China. Series C, Life sciences / Chinese Academy of Sciences"More Details
    17875955 Circulating hepatocyte growth factor level but not basic fibroblast growth factor level is elevated in angiography-proven symptomatic peripheral artery disease.AngiologyMore Details
    16759302 "Clinical significance of circulating hepatocyte growth factor, a new risk marker of carotid atherosclerosis in patients with Type 2 diabetes."Diabetic medicine : a journal of the British Diabetic AssociationMore Details
    17178341 Intravascular ultrasound evidence of angiographically silent allograft vasculopathy inversely correlates with circulating level of hepatocyte growth factor.The Journal of heart and lung transplantation : the official publication of theMore Details
    16625244 Angiogenic and antifibrotic actions of hepatocyte growth factor improve cardiac dysfunction in porcine ischemic cardiomyopathy.Gene therapyMore Details
    16105849 Serum hepatocyte growth factor levels predict long-term clinical outcome after percutaneous coronary revascularization.European heart journalMore Details
    16275167 A scientific rationale for the CREST trial results: evidence for the mechanism of action of cilostazol in restenosis.Atherosclerosis. SupplementsMore Details
    16175467 Therapeutic angiogenesis induced by injecting hepatocyte growth factor in ischemic canine hearts.Surgery todayMore Details
    15367830 Roles of hepatocyte growth factor and mast cells in thrombosis and angiogenesis.Cardiovascular drugs and therapy / sponsored by the International Society ofMore Details
    12521946 Evidence for association of coronary sinus levels of hepatocyte growth factor and collateralization in human coronary disease.American journal of physiology. Heart and circulatory physiologyMore Details
    12826929 Hepatocyte growth factor and vascular endothelial growth factor in ischaemic heart disease.Coronary artery diseaseMore Details
    12124994 Highly multiplexed genotyping of coronary artery disease-associated SNPs using MALDI-TOF mass spectrometry.Human mutationMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.

    PPI interactions

    There were totally 16 unique genes interacted with HGF. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    SDC2 Reconstituted Complex8157651 No
    HGF Co-crystal Structure11597998|11597998,12051906,9817840,9886295 CHD related
    HPN in vitro15792801 No
    PLAU in vitro1334458 CHD related
    VTN in vitro15717924 CHD related
    LCN2 in vitro15637066 No
    CLEC3B Reconstituted Complex12694198|12694198 No
    MET Reconstituted Complex8380735|8380735|19433454|1655405,15167892,18495663 No
    SDC1 Reconstituted Complex11830493|11830493 CHD related
    KIAA0101 Affinity Capture-MS21628590 No
    HDAC7 Negative Genetic22318606 No
    FN1 in vitro15717924 CHD related
    KLKB1 in vitro12372819,10962009 No
    HGFAC in vitro8631970 No
    ST14 in vitro12372819,10962009 No
    F11 in vitro12372819,10962009 No

    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    experimentalDB02264O2-Sulfo-Glucuronic Acid