How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: HLA-E

    Description: "major histocompatibility complex, class I, E"

    Entrez Gene ID: 3133

    SwissProt Acc Number: P13747

    RefSeq: NM_005516

    It was supported literatures to be a novel CHD related gene:

    ..HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of?coronary?artery aneurysms...

    From PMID: 19180512, in Journal Arthritis Rheum. , 2009


    References

    There were 1 potential papers with HLA-E and CHD.

    PMIDTitleJournalsDetails
    19180512 HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of coronary artery aneurysms.Arthritis and rheumatismMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 9 unique genes interacted with HLA-E. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    B2M Co-crystal Structure9605335|9605335,10064069 CHD related
    PPP1R16A yeast 2-hybrid16169070 No
    HLA-E in vitro9605335 CHD related
    KLRD1 Reconstituted Complex9886400|14734748,9815261,9486650,9886400 No
    UBC Affinity Capture-MS21890473|21906983 No
    UBD Affinity Capture-MS22797925 No
    KLRC1 in vivo9486650 No
    CD8A in vitro10809759 No
    KLRC2 in vivo9486650,9103421 No


    Involved FDA drugs

    There was no drug associated with HLA-E