How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: HP

    Description: haptoglobin

    Entrez Gene ID: 3240

    SwissProt Acc Number: P00738

    RefSeq: NM_001126102

    It was suspected to be CHD related:

    .."The combined group samples identified 6 up regulated differential expression (DE) genes (GHRL, LTA,CBS, HP, ITGA2B, and OLR1) and 12 down regulated DE genes (IL18R1, ITGA2B,IL18RAP, HP, OLR1, SOD2 ITGB3, IL1B, MMP9, PLA2G7, UTS2, and CBS) to be involved in CAD "..

    From PMID: 22738689, in Journal J Cardiol. , 2012


    References

    There were 35 potential papers with HP and CHD.

    PMIDTitleJournalsDetails
    24075749 Haptoglobin 2 allele associates with unstable carotid plaque and major cardiovascular events.AtherosclerosisMore Details
    23078847 Oxidized ApoC1 on MALDI-TOF and glycated-ApoA1 band on gradient gel as potential diagnostic tools for atherosclerotic vascular disease.Clinica chimica acta; international journal of clinical chemistryMore Details
    23445629 The role of hemorheological factors in cardiovascular medicine.Clinical hemorheology and microcirculationMore Details
    23312704 Haptoglobin genotype is a consistent marker of coronary heart disease risk among individuals with elevated glycosylated hemoglobin.Journal of the American College of CardiologyMore Details
    24130793 Plasma haptoglobin concentrations are elevated in patients with coronary artery disease.PloS oneMore Details
    22738689 Peripheral blood gene expression profile of atherosclerotic coronary artery disease in patients of different ethnicity in Malaysia.Journal of cardiologyMore Details
    23150107 "[Current clinical practice among German Internists regarding the prophylaxis of gastroduodenal ulcers associated with NSAIDs, aspirin and Helicobacter pylori]."Zeitschrift fur GastroenterologieMore Details
    22038196 "Comparison of epitope specificity of anti-heat shock protein 60/65 IgG type antibodies in the sera of healthy subjects, patients with coronary heart disease and inflammatory bowel disease."Cell stress & chaperonesMore Details
    22766337 Increased expression of oxidation-specific epitopes and apoptosis are associated with haptoglobin genotype: possible implications for plaque progression in human atherosclerosis.Journal of the American College of CardiologyMore Details
    21296538 Haptoglobin phenotypes and plasma haptoglobin levels in patients with abdominal aortic aneurysm.Journal of vascular surgeryMore Details
    21287512 [Association of haptoglobin 1/2 polymorphism with coronary heart disease in Chinese].Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = ChineseMore Details
    21496172 Electrovectorcardiographic diagnosis of left septal fascicular block: anatomic and clinical considerations.Annals of noninvasive electrocardiology : the official journal of theMore Details
    22098782 Haptoglobin genotype predicts development of coronary artery calcification in a prospective cohort of patients with type 1 diabetes.Cardiovascular diabetologyMore Details
    20134372 "Effect of Helicobacter pylori eradication on insulin resistance, serum lipids and low-grade inflammation."Southern medical journalMore Details
    18770033 Helicobacter pylori seropositivity in patients with acute coronary syndromes.Digestive diseases and sciencesMore Details
    19433579 Hemoglobin and its scavenger protein haptoglobin associate with apoA-1-containing particles and influence the inflammatory properties and function of high density lipoprotein.The Journal of biological chemistryMore Details
    18572262 Coronary artery disease patient's first degree relatives may be at higher risk for atherosclerosis.International journal of cardiologyMore Details
    19412916 The QuantumCor device for treating mitral regurgitation: an animal study.Catheterization and cardiovascular interventions : official journal of theMore Details
    19760229 Diagnostic accuracy of high-pitch dual-source CT for the assessment of coronary stenoses: first experience.European radiologyMore Details
    19204177 Association of remote hypertension in pregnancy with coronary artery disease: a case-control study.HypertensionMore Details
    18063147 Common community infections and the risk for coronary artery disease and acute myocardial infarction: evidence for chronic over-expression of tumor necrosis factor alpha and vascular cells adhesion molecule-1.International journal of cardiologyMore Details
    17548077 Gender-related differences in oxidative stress levels among elderly patients with coronary artery disease.Fertility and sterilityMore Details
    18164958 Resveratrol reverses hydrogen peroxide-induced proliferative effects in human coronary smooth muscle cells: a novel signaling mechanism.Archives of medical researchMore Details
    17403600 "Ion transport, membrane fluidity and haemoglobin conformation in erythrocyte from patients with cardiovascular diseases: Role of augmented plasma cholesterol."Pathophysiology : the official journal of the International Society forMore Details
    17510505 Pulse wave velocity as a marker of arteriosclerosis and its comorbidities in Chinese patients.Hypertension research : official journal of the Japanese Society of HypertensionMore Details
    17378734 Oxidative stress evaluated using an automated method for hydroperoxide estimation in patients with coronary artery disease.Clinical chemistry and laboratory medicine : CCLM / FESCCMore Details
    16864009 Endothelial function parameters in patients with unstable angina and infection with Helicobacter pylori and Chlamydia pneumoniae.European journal of internal medicineMore Details
    16115849 Myocardial contractility does not determine the haemodynamic response during dialysis."Nephrology, dialysis, transplantation : official publication of the European"More Details
    16004887 Triple-coated stents (Hirudin/Iloprost/Paclitaxel): an in vitro approach for characterizing the antiproliferative potential of each individual compound.International journal of cardiologyMore Details
    15019547 Haptoglobin phenotype and prevalent coronary heart disease in the Framingham offspring cohort.AtherosclerosisMore Details
    12681997 Absence of association between infectious agents and endothelial function in healthy young men.CirculationMore Details
    11603909 The impact of high pressure vs low pressure stent implantation on intimal hyperplasia and follow-up lumen dimensions; results of a randomized trial.European heart journalMore Details
    11162133 Hypoxia/reoxygenation promotes myocardial angiogenesis via an NF kappa B-dependent mechanism in a rat model of chronic myocardial infarction.Journal of molecular and cellular cardiologyMore Details
    11054629 A prospective evaluation of angiography-guided coronary stent implantation with high versus very high balloon inflation pressure.American heart journalMore Details
    10820865 [Helicobacter pylori and coronary heart diseases--hypotheses and facts].Zeitschrift fur GastroenterologieMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 12 unique genes interacted with HP. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    HBB Affinity Capture-Western7378053 No
    ITGAM in vivo11967116 CHD related
    CD22 in vivo11967116 No
    MIS12 Affinity Capture-MS20360068 No
    GRB2 Two-hybrid18624398 CHD related
    RBBP6 Two-hybrid18624398 No
    ELAVL1 Affinity Capture-RNA19322201 No
    ATP7B Two-hybrid16676348 No
    C1RL in vitro15385675 No
    ADAMTS4 yeast 2-hybrid16099106 CHD related
    ITGB2 in vivo11967116 CHD related
    CD163 in vivo11854028 CHD related


    Involved FDA drugs

    There was no drug associated with HP