How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: HPR

    Description: haptoglobin-related protein

    Entrez Gene ID: 3250

    SwissProt Acc Number: P00739

    RefSeq: NM_020995

    It was supported literatures to be a novel CHD related gene:

    ..Coronary artery disease has been linked with genotypes for haptoglobin (Hp) which modulates extracorpuscular hemoglobin...

    From PMID: 22098782, in Journal Cardiovasc Diabetol. , 2011


    References

    There were 30 potential papers with HPR and CHD.

    PMIDTitleJournalsDetails
    24076493 Consensus and Update on the Definition of On-Treatment Platelet Reactivity to ADP Associated with Ischemia and Bleeding.Journal of the American College of CardiologyMore Details
    24043374 "Higher body weight patients on clopidogrel maintenance therapy have lower active metabolite concentrations, lower levels of platelet inhibition, and higher rates of poor responders than low body weight patients."Journal of thrombosis and thrombolysisMore Details
    23602777 Platelet responsiveness to clopidogrel treatment after peripheral endovascular procedures: the PRECLOP study: clinical impact and optimal cutoff value of on-treatment high platelet reactivity.Journal of the American College of CardiologyMore Details
    23588781 Monitoring aspirin and clopidogrel response: testing controversies and recommendations.Molecular diagnosis & therapyMore Details
    23677387 Differences in high on-treatment platelet reactivity between intra-coronary and peripheral blood after dual anti-platelet agents in patients with coronary artery disease.Thrombosis and haemostasisMore Details
    22431415 Pharmacodynamic effects of adjunctive cilostazol therapy in patients with coronary artery disease on dual antiplatelet therapy: impact of high on-treatment platelet reactivity and diabetes mellitus status.Catheterization and cardiovascular interventions : official journal of theMore Details
    23040597 Prasugrel monitoring and bleeding in real world patients.The American journal of cardiologyMore Details
    22507978 Accelerated platelet inhibition by switching from atorvastatin to a non-CYP3A4-metabolized statin in patients with high platelet reactivity (ACCEL-STATIN) study.European heart journalMore Details
    23083774 Reduction in platelet reactivity with prasugrel 5 mg in low-body-weight patients is noninferior to prasugrel 10 mg in higher-body-weight patients: results from the FEATHER trial.Journal of the American College of CardiologyMore Details
    22595163 High platelet reactivity on clopidogrel therapy correlates with increased coronary atherosclerosis and calcification: a volumetric intravascular ultrasound study.JACC. Cardiovascular imagingMore Details
    22440495 Cigarette smoking is associated with a dose-response effect in clopidogrel-treated patients with diabetes mellitus and coronary artery disease: results of a pharmacodynamic study.JACC. Cardiovascular interventionsMore Details
    22440493 A therapeutic window for platelet reactivity for patients undergoing elective percutaneous coronary intervention: results of the ARMYDA-PROVE (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty-Platelet Reactivity for Outcome Validation Effort) study.JACC. Cardiovascular interventionsMore Details
    22311629 Description of response to aspirin and clopidogrel in outpatients with coronary artery disease using multiple electrode impedance aggregometry.Clinical and applied thrombosis/hemostasis : official journal of theMore Details
    22249353 Tailoring clopidogrel dose according to multiple electrode aggregometry decreases the rate of ischemic complications after percutaneous coronary intervention.Journal of thrombosis and thrombolysisMore Details
    22627684 Translational platelet research in patients with coronary artery disease: what are the major knowledge gaps?Thrombosis and haemostasisMore Details
    22123356 The gain-of-function variant allele CYP2C19*17: a double-edged sword between thrombosis and bleeding in clopidogrel-treated patients.Journal of thrombosis and haemostasis : JTHMore Details
    21371863 Impact of concomitant use of proton-pump inhibitors and thienopyridine derivatives on the antiplatelet effects.Journal of cardiologyMore Details
    21392617 The relation between CYP2C19 genotype and phenotype in stented patients on maintenance dual antiplatelet therapy.American heart journalMore Details
    21716590 Detection of clopidogrel hyporesponsiveness using a point-of-care assay and the impact of additional cilostazol administration after coronary stent implantation in diabetic patients.The Korean journal of internal medicineMore Details
    21742103 The effect of ticagrelor versus clopidogrel on high on-treatment platelet reactivity: combined analysis of the ONSET/OFFSET and RESPOND studies.American heart journalMore Details
    21075428 The cytochrome 2C19*2 and *3 alleles attenuate response to clopidogrel similarly in East Asian patients undergoing elective percutaneous coronary intervention.Thrombosis researchMore Details
    21628721 Variability in on-treatment platelet reactivity explained by CYP2C19*2 genotype is modest in clopidogrel pretreated patients undergoing coronary stenting.Heart (British Cardiac Society)More Details
    20723634 Comparison of platelet reactivity and periprocedural outcomes in patients with versus without diabetes mellitus and treated with clopidogrel and percutaneous coronary intervention.The American journal of cardiologyMore Details
    20826265 Prognostic significance of high on-clopidogrel platelet reactivity after percutaneous coronary intervention: systematic review and meta-analysis.American heart journalMore Details
    20725815 Antiplatelet effect of once- or twice-daily aspirin dosage in stable coronary artery disease patients with diabetes.International journal of hematologyMore Details
    20298992 Point-of-care assessment of platelet reactivity after clopidogrel to predict myonecrosis in patients undergoing percutaneous coronary intervention.JACC. Cardiovascular interventionsMore Details
    20138334 The GPIIIa PlA polymorphism and the platelet hyperactivity in Tunisian patients with stable coronary artery disease treated with aspirin.Thrombosis researchMore Details
    20129566 High residual platelet reactivity after clopidogrel: extent of coronary atherosclerosis and periprocedural myocardial infarction in patients with stable angina undergoing percutaneous coronary intervention.JACC. Cardiovascular interventionsMore Details
    19817997 The effect of elinogrel on high platelet reactivity during dual antiplatelet therapy and the relation to CYP2C19*2 genotype: first experience in patients.Journal of thrombosis and haemostasis : JTHMore Details
    17936152 Impact of platelet reactivity on cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease.Journal of the American College of CardiologyMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 4 unique genes interacted with HPR. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    CD40LG Affinity Capture-Western10085035 CHD related
    ORF57 Affinity Capture-Western18974867 No
    IGHM in vitro10085035 No
    APOA1 in vitro10085035 CHD related


    Involved FDA drugs

    There was no drug associated with HPR