How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: HSPA1A

    Description: heat shock 70kDa protein 1A

    Entrez Gene ID: 3303

    SwissProt Acc Number: P08107

    RefSeq: NM_005345

    It was suspected to be CHD related:

    .."Eight genes, namely MMP2, PTGS2, PECAM1, SELP, SELL, CYP1A1, MMRN1, and HSPA1A, were involved in atherosclerosis and myocardial infarction."..

    From PMID: 22126760, in Journal Nan Fang Yi Ke Da Xue Xue Bao , 2011


    References

    There were 3 potential papers with HSPA1A and CHD.

    PMIDTitleJournalsDetails
    21439970 Identification of a NF-kappaB cardioprotective gene program: NF-kappaB regulation of Hsp70.1 contributes to cardioprotection after permanent coronary occlusion.Journal of molecular and cellular cardiologyMore Details
    21849784 Variants of HSPA1A in combination with plasma Hsp70 and anti-Hsp70 antibody levels associated with higher risk of acute coronary syndrome.CardiologyMore Details
    19333379 Functional SNPs in HSPA1A gene predict risk of coronary heart disease.PloS oneMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 135 unique genes interacted with HSPA1A. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    AR Affinity Capture-Western1540595 CHD related
    BAG1 Reconstituted Complex14517289 No
    MSR1 Affinity Capture-Western11785981|11785981 CHD related
    RHOA Affinity Capture-Western12490434 CHD related
    NR3C1 Reconstituted Complex12093808|12093808 CHD related
    MAP3K5 Reconstituted Complex12391142 CHD related
    BCL2 Affinity Capture-Western10354271 CHD related
    CDK9 Affinity Capture-Western10617616 No
    SNCA FRET19875982 No
    SNCB FRET19875982 No
    TP53 Affinity Capture-Western8729618 CHD related
    HSPA8 Co-fractionation22939629 CHD related
    HSPA2 Co-fractionation22939629 No
    HSPA6 Co-fractionation22939629 No
    MYH9 Co-fractionation22939629 No
    SRSF2 Co-fractionation22939629 No
    STOML2 Co-fractionation22939629 No
    NONO Co-fractionation22939629 No
    YBX1 Co-fractionation22939629 CHD related
    APOB in vitro9252351 CHD related
    APEX1 in vitro;in vivo11133992,10629618 CHD related
    RAP1A in vivo15207703 No
    NQO1 in vitro11821413 CHD related
    DYX1C1 in vivo15189447 No
    HSPA1A in vivo12930708 CHD related
    FANCC Affinity Capture-Western12397061|14499622|11500375,12397061 No
    AIFM1 Affinity Capture-Western12930708|11533664,12930708 No
    IKBKG Reconstituted Complex11877453|11877453 No
    HSF1 Affinity Capture-Western9499401|9499401|21784850|1628823,9699716 CHD related
    HSP90AA1 Reconstituted Complex12093808 CHD related
    RBX1 Affinity Capture-MS12481031 No
    CUL4A Affinity Capture-MS12481031|21145461 No
    SLC5A1 Affinity Capture-Western12082088|12082088 No
    STUB1 Reconstituted Complex10330192|10330192|10330192,15189447 No
    BAG6 Affinity Capture-Western11230127 No
    BAG3 Affinity Capture-Western10980614|11527400|9873016,10980614 No
    SOX9 Affinity Capture-Western11356186|11356186 No
    ST13 Reconstituted Complex8887650|8887650 No
    PARK2 Affinity Capture-MS12150907|12150907|12150907 No
    GPR37 Affinity Capture-Western12150907 No
    PACSIN1 Affinity Capture-MS19041431 No
    PACSIN2 Affinity Capture-MS19041431 No
    PACSIN3 Affinity Capture-MS19041431 No
    FNBP1 Affinity Capture-MS19041431 No
    PSTPIP1 Affinity Capture-MS19041431 No
    FCHSD1 Affinity Capture-MS19041431 No
    EGFR PCA20029029 CHD related
    RAPGEF2 Two-hybrid20936779 No
    MYSM1 Affinity Capture-MS17707232 No
    SUMO2 Affinity Capture-MS19394292|21693764|19471022 No
    SRRM2 Affinity Capture-MS16159877 No
    KDM1A Affinity Capture-MS16140033 No
    MAX Affinity Capture-MS20946988 No
    H2AFX Affinity Capture-MS20000738 No
    UBC Affinity Capture-MS16196087|20639865|20972266|21963094|22505724 No
    USP50 Affinity Capture-MS20930503 No
    EIF2C4 Affinity Capture-MS19167051 No
    MME Affinity Capture-MS17342744 No
    HDAC5 Affinity Capture-MS21081666 No
    DYRK2 Affinity Capture-MS19287380 No
    YWHAG Affinity Capture-MS15324660|15324660 No
    STK11 Affinity Capture-MS14676191 CHD related
    INSIG2 Affinity Capture-MS19815544 No
    SUMO1 Affinity Capture-MS19596686 No
    BAP1 Co-purification20805357 No
    KIAA0101 Affinity Capture-MS21628590 No
    SUMO4 Affinity Capture-MS16236267 CHD related
    ISG15 Affinity Capture-MS16009940 No
    POT1 Two-hybrid21044950 No
    TERT Affinity Capture-Western20959453 CHD related
    EBNA-LP Affinity Capture-Western17341665 No
    KIAA0368 Affinity Capture-MS20682791 No
    NFX1 Affinity Capture-MS17267499 No
    CUL3 Affinity Capture-MS21145461 No
    CUL4B Affinity Capture-MS21145461 No
    CUL5 Affinity Capture-MS21145461 No
    CUL2 Affinity Capture-MS21145461 No
    CUL1 Affinity Capture-MS21145461 No
    COPS5 Affinity Capture-MS21145461 No
    COPS6 Affinity Capture-MS21145461 No
    DCUN1D1 Affinity Capture-MS21145461 No
    CAND1 Affinity Capture-MS21145461 No
    NEDD8 Affinity Capture-MS21145461 No
    VHL Co-fractionation14636579 No
    ATXN1 Two-hybrid16713569 No
    C1orf124 Affinity Capture-MS23042605 No
    DIS3L Affinity Capture-MS20531386 No
    UBXN6 Affinity Capture-MS22337587 No
    LMAN1 Affinity Capture-MS22337587 No
    HSP90AB1 Co-fractionation22939629 CHD related
    HSPD1 Co-fractionation22939629 CHD related
    EEF1A1 Co-fractionation22939629 No
    HSPA1L Co-fractionation22939629 No
    CPS1 Co-fractionation22939629 No
    DDX1 Co-fractionation22939629 No
    CARHSP1 Co-fractionation22939629 No
    HSPA5 Co-fractionation22939629 No
    ATP5A1 Co-fractionation22939629 No
    GCN1L1 Co-fractionation22939629 No
    HSBP1 in vitro;in vivo9649501 No
    CACNA1E in vivo16543726 No
    TRIAP1 in vitro;in vivo15735003 No
    WDR16 in vivo15967112 No
    BRSK1 in vitro;in vivo16306228 No
    SNRK in vitro;in vivo16306228 No
    TSSK6 in vivo15870294 No
    YWHAQ in vivo15324660 No
    KRT7 in vivo11888936 No
    EIF2AK2 in vivo12397061 No
    PRKCA in vitro;in vivo12080070 CHD related
    PTMA in vitro11310559 No
    MOS in vitro;in vivo10376524 No
    HCFC1 in vitro12670868 No
    PEX5 in vitro11415446 No
    DNAJC3 in vivo;yeast 2-hybrid9920933 No
    YWHAZ in vivo15324660 No
    YWHAB in vivo15324660 No
    APAF1 in vivo10934467 No
    GRIN2D in vivo10862698 No
    TRIM24 in vitro;in vivo12677068 No
    BAG2 in vitro;in vivo;yeast 2-hybrid9873016 No
    BAG4 in vitro;in vivo11527400,11909948 No
    DNAJB1 in vitro;in vivo10593983 No
    STIP1 in vitro;in vivo12161444,10786835 No
    PTGES3 in vivo12077419 No
    PPP1R15A in vivo12724406 No
    DNAJA2 in vitro10651811 No
    DNAJB11 in vitro11584023 No
    DNAJA3 in vivo11679576,14993262 No
    HSPBP1 in vitro;yeast 2-hybrid9830037 No
    TCERG1 in vitro15456888 No
    TTC1 in vitro14503850 No
    GRIN1 in vivo10862698 No
    TOMM70A in vivo12526792 No
    KRT18 in vitro7529764 No


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    experimentalDB03431Adenosine-5'-Diphosphate