How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: HSPA8

    Description: heat shock 70kDa protein 8

    Entrez Gene ID: 3312

    SwissProt Acc Number: P11142

    RefSeq: NM_006597

    It was suspected to be CHD related:

    ..These findings suggest that genetic variants in HSPA8 gene (especially promoter SNP rs2236659) contribute to the CHD susceptibility by affecting its expression level...

    From PMID: 20300519, in Journal PLoS One. , 2010


    References

    There were 1 potential papers with HSPA8 and CHD.

    PMIDTitleJournalsDetails
    20300519 Genetic variations in HSPA8 gene associated with coronary heart disease risk in a Chinese population.PloS oneMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 209 unique genes interacted with HSPA8. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    HSPBP1 Two-hybrid16189514 No
    NOA1 Two-hybrid16169070 No
    TM4SF1 Two-hybrid16169070|16169070 No
    ERH Two-hybrid16169070|16169070 No
    FBP1 Two-hybrid16169070 No
    UBC Two-hybrid16169070|15936278 No
    HSP90AA1 Affinity Capture-Western9269769|9269769 CHD related
    PPP1CA Affinity Capture-Western9269769 No
    PPP1R12B Affinity Capture-Western9269769 No
    BAG2 Two-hybrid9873016|9873016 No
    BAG3 Two-hybrid9873016|9873016 No
    VCP Affinity Capture-Western16621797|22939629 No
    CCND1 Affinity Capture-Western18537972 CHD related
    CDK4 Affinity Capture-Western18537972 CHD related
    HTT Reconstituted Complex20026656 No
    BCR Reconstituted Complex20675402|20675402 CHD related
    ABL1 Reconstituted Complex20675402|20675402 No
    CAPZB Affinity Capture-Western20884878 No
    CAPZA1 Affinity Capture-Western20884878 No
    VAMP2 Co-fractionation22939629 No
    PRKDC Co-fractionation22939629 No
    RNPS1 Co-fractionation22939629 No
    PDIA3 Co-fractionation22939629 No
    HNRNPA3 Co-fractionation22939629 No
    RPS4X Co-fractionation22939629 No
    SAMM50 Co-fractionation22939629 No
    SEC24C Co-fractionation22939629 No
    STIP1 Co-fractionation22939629 No
    SSBP1 Co-fractionation22939629 No
    RPS15A Co-fractionation22939629 No
    RPL18A Co-fractionation22939629 No
    NECAP2 Co-fractionation22939629 No
    SON Co-fractionation22939629 No
    RPL8 Co-fractionation22939629 No
    SEC31A Co-fractionation22939629 No
    POU2F1 Co-fractionation22939629 No
    REL in vitro2155506 No
    APOB in vivo9694898 CHD related
    RB1 in vitro;in vivo7673249 CHD related
    SP1 in vitro10976766 No
    ALDOB in vivo11241348 No
    DYNLL1 in vitro14760703 No
    GAK in vitro;in vivo10625686 No
    ABI1 in vitro15048123 No
    CXCR4 in vitro;in vivo16365278 CHD related
    HSPA8 in vitro;in vivo11679576,14993262,7578144 CHD related
    DPP3 yeast 2-hybrid16169070 No
    C4orf14 yeast 2-hybrid16169070 No
    BAG1 Two-hybrid9305631|9873016|9873016|9305631|9305631|17954934|20675402|10671488|12874020|12874020|14978028 No
    PPID Reconstituted Complex15497503|15497503 No
    TCERG1 Affinity Capture-MS15456888|15456888 No
    BRCA1 Two-hybrid9738006 CHD related
    FANCC Two-hybrid14499622|11500375|11500375 No
    PPP1R15A Affinity Capture-Western12724406 No
    HCFC1 Affinity Capture-MS12670868 No
    HDAC3 Reconstituted Complex12502735 CHD related
    P2rx7 Affinity Capture-MS11707406|11707406 No
    CITED1 Affinity Capture-Western10722728|10722728 No
    TADA3 Two-hybrid16169070 No
    RGS2 Two-hybrid16169070|21900206|16169070 No
    DNAJA3 Affinity Capture-Western11679576|11679576,14993262 No
    JAK2 Affinity Capture-Western11679576 CHD related
    DNAJB1 Reconstituted Complex10075921 No
    DNAJA1 Reconstituted Complex10075921 No
    TCP1 Reconstituted Complex10075921 No
    CFTR Affinity Capture-Western10075921|15611333|17272822|17272822 CHD related
    RBX1 Affinity Capture-MS12481031 No
    DNAJC3 Affinity Capture-Western11116152 No
    CYCS Reconstituted Complex8663341 No
    POLR3D Affinity Capture-MS12391170 No
    TP53 Reconstituted Complex11297531 CHD related
    BAG4 Reconstituted Complex11909948 No
    TNFRSF1A Reconstituted Complex11909948 CHD related
    STMN1 Reconstituted Complex10197448 No
    GOT2 Reconstituted Complex7559589 No
    STUB1 Reconstituted Complex10330192|10330192|10330192|15538384|15538384|11557750|21454478|21454478|20618441|21911421|21911421|15198682|16275660|16275660|16293251|16207813|15215316|11146634 No
    HSF1 Reconstituted Complex7639722|16293251 CHD related
    PARK2 Affinity Capture-Western12150907|12150907|14532270 No
    GPR37 Affinity Capture-Western12150907 No
    CDC5L Affinity Capture-MS11101529|11101529 No
    HGS Reconstituted Complex19019082 No
    HNRNPD Affinity Capture-Western18573886|10205060 No
    MAPT Affinity Capture-Western17954934|14612456|14612456 No
    RUVBL1 Affinity Capture-MS17643375 No
    GPN1 Affinity Capture-MS17643375 No
    RPAP1 Affinity Capture-MS17643375 No
    PACSIN1 Affinity Capture-MS19041431 No
    PACSIN2 Affinity Capture-MS19041431 No
    PACSIN3 Affinity Capture-MS19041431 No
    HDAC10 Affinity Capture-Western20032463|20032463 CHD related
    EGFR PCA20029029 CHD related
    MST1R Affinity Capture-Western16740632 No
    RFWD2 Affinity Capture-MS16497536 No
    SEC61B Affinity Capture-MS20516149 No
    SERP1 Affinity Capture-MS20516149 No
    ESR1 Affinity Capture-Western16037132|15538384|20308691 CHD related
    SOD1 Affinity Capture-MS15358145 CHD related
    CDK11B Affinity Capture-MS15344906 No
    SUMO2 Affinity Capture-MS19394292|21693764|19471022|21252943 No
    TSSK6 Affinity Capture-MS15870294|15870294 No
    HIST3H3 Co-purification20953179|20953179 No
    MEN1 Affinity Capture-MS15254225 No
    IL16 Reconstituted Complex18097041|18097041 No
    CENPA Co-purification15009096 No
    WDR82 Affinity Capture-MS20516061 No
    RAF1 Affinity Capture-Western20039095|16093354 CHD related
    CDK5RAP3 Affinity Capture-MS20164180 No
    FGFR3 Affinity Capture-MS21487019 No
    ERG Affinity Capture-Western21183741|21575865 No
    USP50 Affinity Capture-MS20930503 No
    LALBA Reconstituted Complex20618441 No
    CLTA Protein-peptide1975516 No
    EIF2C4 Affinity Capture-MS19167051 No
    CD4 Affinity Capture-MS15047060 CHD related
    DGCR8 Affinity Capture-MS17765891 No
    MME Affinity Capture-MS17342744 No
    TLR4 Affinity Capture-Western21911421 CHD related
    TLR9 Affinity Capture-Western21911421 No
    MDM2 Affinity Capture-Western20540933 CHD related
    DYRK2 Affinity Capture-MS19287380 No
    UBE3A Affinity Capture-Western19233847 No
    CDKN2A Affinity Capture-MS17955473 CHD related
    YWHAQ Affinity Capture-MS15324660 No
    INSIG2 Affinity Capture-MS19815544 No
    HMGB1 Affinity Capture-Western12517784 CHD related
    HLA-DRA Affinity Capture-MS20458337 No
    HLA-DRB1 Affinity Capture-MS20458337 CHD related
    HLA-DRB3 Affinity Capture-MS20458337 No
    HLA-DRB4 Affinity Capture-MS20458337 No
    HLA-DRB5 Affinity Capture-MS20458337 No
    EBNA-LP Affinity Capture-Western18457437|18457437|18457437 No
    PSMA3 Affinity Capture-MS22079093 No
    MAPK8 Two-hybrid21900206 CHD related
    SUMO1 Affinity Capture-MS19596686 No
    VHL Affinity Capture-MS21942715|22234250 No
    KIAA0101 Affinity Capture-MS21628590 No
    Psma2 Affinity Capture-MS17139257 No
    SUMO4 Affinity Capture-MS16236267|16236267 CHD related
    lqf Affinity Capture-Western15694383 No
    clint1-a Affinity Capture-Western15694383 No
    SF3A2 Affinity Capture-MS17332742 No
    ARRB1 Affinity Capture-MS17620599|17620599 No
    ARRB2 Affinity Capture-MS17620599|17620599 No
    MKKS Affinity Capture-Western18094050 No
    ATXN1 Affinity Capture-Western17127076 No
    PARD3 Affinity Capture-MS18685789 No
    ISG15 Affinity Capture-MS16009940|16815975 No
    FBXO25 Affinity Capture-MS20473970 No
    DNAJB2 Affinity Capture-Western15936278 No
    UCHL1 Affinity Capture-Western18550537|18635949|18550537 No
    PPP1CC Affinity Capture-MS17683050|17683050 No
    CUL3 Affinity Capture-MS21145461 No
    CUL4A Affinity Capture-MS21145461 No
    SNCA Reconstituted Complex22843682|21832061|22776201|17893145 No
    CUL4B Affinity Capture-MS21145461 No
    CUL5 Affinity Capture-MS21145461 No
    CUL2 Affinity Capture-MS21145461 No
    CDK2 Affinity Capture-MS21319273 No
    CUL1 Affinity Capture-MS21145461 No
    COPS5 Affinity Capture-MS21145461 No
    COPS6 Affinity Capture-MS21145461 No
    DCUN1D1 Affinity Capture-MS21145461 No
    CAND1 Affinity Capture-MS21145461 No
    NEDD8 Affinity Capture-MS21145461 No
    MCL1 Affinity Capture-Western19148187 No
    PPP2R1A Affinity Capture-MS18172692 No
    EEF1A1 Affinity Capture-Western18172692 No
    HERC5 Affinity Capture-Western16815975 No
    SGTA Affinity Capture-Western16777091 No
    FAF1 Affinity Capture-Western15596450 No
    KCND3 Affinity Capture-Western17725712 No
    BCAS2 Co-fractionation20176811 No
    CWC15 Co-fractionation20176811 No
    AIPL1 Two-hybrid18408180|18408180|18408180 No
    HSPA4 Co-fractionation18408180|22939629 No
    LRRK2 Affinity Capture-MS17400507|18367605|19826009 No
    APP Affinity Capture-Western21150129 No
    ZFYVE20 Affinity Capture-Western19931244 No
    AKT1 Affinity Capture-MS16027165 CHD related
    C1orf124 Affinity Capture-MS23042605 No
    DNAJB14 Affinity Capture-Western23018488 No
    INPPL1 Affinity Capture-MS19380743 No
    CBL Affinity Capture-MS19380743 No
    UBASH3B Affinity Capture-MS19380743 No
    GRB2 Affinity Capture-MS19380743 CHD related
    PIK3R2 Affinity Capture-MS19380743 No
    SHC1 Affinity Capture-MS19380743 No
    CRK Affinity Capture-MS19380743 No
    EPS15 Affinity Capture-MS19380743 No
    AP2M1 Affinity Capture-MS19380743 No
    ATP13A2 Two-hybrid22645275|22645275 No
    LMAN1 Affinity Capture-MS22337587 No
    RAD23A Affinity Capture-MS16712842 No
    IRAK1 Affinity Capture-MS15647277 CHD related
    GCH1 Two-hybrid16696853|16696853 CHD related
    Bax Affinity Capture-Western14752510 No
    HSPA5 Co-fractionation22939629 No
    HSPD1 Co-fractionation22939629 CHD related
    HSPA2 Co-fractionation22939629 No
    EEF2 Co-fractionation22939629 No
    DNAJB12 Co-fractionation22939629 No
    HSPA1A Co-fractionation22939629 CHD related
    HSPH1 in vivo9675148 No
    CCT3 in vivo10635329 No
    CD40 in vivo12356871 CHD related
    YWHAG in vivo15324660 No
    COL7A1 yeast 2-hybrid16169070 No
    PHC1 yeast 2-hybrid16169070 No
    BAT3 in vitro11230127 CHD related


    Involved FDA drugs

    StatusDrubBank IDNameIndicationATC Code
    experimentalDB03431Adenosine-5'-Diphosphate
    experimentalDB07045"(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol"