How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: IL10

    Description: interleukin 10

    Entrez Gene ID: 3586

    SwissProt Acc Number: P22301

    RefSeq: NM_000572

    It was suspected to be CHD related:

    ..These results indicate that the C allele with SNPs at position -592C/A and -819C/T of IL10 gene may be associated with IHD in the Korean population...

    From PMID: 22592860, in Journal Inflamm Res , 2012


    References

    There were 12 potential papers with IL10 and CHD.

    PMIDTitleJournalsDetails
    24101519 Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart.Proceedings of the National Academy of Sciences of the United States of AmericaMore Details
    23223950 CXCR4 positive and angiogenic monocytes in myocardial infarction.Thrombosis and haemostasisMore Details
    22592860 Association of promoter region single nucleotide polymorphisms at positions -819C/T and -592C/A of interleukin 10 gene with ischemic heart disease.Inflammation research : official journal of the European Histamine ResearchMore Details
    21052690 The 5352 A allele of the pro-inflammatory caspase-1 gene predicts late-acquired stent malapposition in STEMI patients treated with sirolimus stents.Heart and vesselsMore Details
    19700159 Polymorphism in the IL10 promoter region and early markers of atherosclerosis: the Cardiovascular Risk in Young Finns Study.AtherosclerosisMore Details
    21187577 Role of genetic polymorphisms in myocardial infarction at young age.Clinical hemorheology and microcirculationMore Details
    19084425 Association of IL6 and IL10 with renal dysfunction and the use of haemofiltration during cardiopulmonary bypass.European journal of cardio-thoracic surgery : official journal of the EuropeanMore Details
    18680534 "PROC, PROCR and PROS1 polymorphisms, plasma anticoagulant phenotypes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health Study."Journal of thrombosis and haemostasis : JTHMore Details
    18802018 Impaired Notch4 activity elicits endothelial cell activation and apoptosis: implication for transplant arteriosclerosis."Arteriosclerosis, thrombosis, and vascular biology"More Details
    18221501 Estimating effects of rare haplotypes on failure time using a penalized Cox proportional hazards regression model.BMC geneticsMore Details
    16550343 Pro-inflammatory/anti-inflammatory cytokine imbalance in acute coronary syndromes.Clinical and experimental medicineMore Details
    15302839 Endogenous angiotensin II induces atherosclerotic plaque vulnerability and elicits a Th1 response in ApoE-/- mice.HypertensionMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 4 unique genes interacted with IL10. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    IL10 Co-crystal Structure8590020|8590020,11717514,7759550 CHD related
    IL10RB in vitro;in vivo11485736,9312047 No
    IL10RA Co-purification8248239|11485736,8248239,8897595,11717514,10231374,7759550 CHD related
    A2M Reconstituted Complex10714547 No


    Involved FDA drugs

    There was no drug associated with IL10