How to Build CHD@ZJU

CHD related Articles were retrieved from Pubmed, by entering keywords "coronary heart disease" and constrict the publish date from 2000/1/1 to now (2013/1/23). As a result, totally 115898 articles were found and their abstracts were downloaded for text mining. Since some articles didn't contain abstracts, only 88396 abstracts remained.

The text-mining process to get CHD related genes could be divided in to 5 following steps:

  • 1) Extracting all keywords from abstracts and ignoring those keywords start with numbers. 101402 keywords were extracted.

  • 2) Input these keywords into Gene library in ArrayTrack and find possible related genes. 4674 genes were then found.

  • 3) Put these 4674 genes again into pubmed abstracts to find related aticles. Only genes which offical name or there keyword description (such as prolactin for gene PRL) could be found in the abstract would be remained. As a result, 1247 genes were remained.

  • 4) Manually examined on the 1247 genes to validate it was acutally related to CHD. Some genes would be filtered if it represents other meanings (such as gene CAD, Entrez ID:790, carbamoyl-phosphate synthetase 2, is mostly meant coronary arterial disease in articles). 681 genes were then validated with at least one reference.

  • 5) All genes was compared with 1078 CHD genes in RGD database, and 370 genes were overlapped. These 370 genes were labels as "RGD_Supported" and the other 293 genes were labels as "REFERED". All 663 genes had supported references in CHD@ZJU which were examined by step 4.
  • How To contact Us

    Collaboration Information: Prof. Xiaohui Fan (fanxh@zju.edu.cn)

    Website using assistance : Leihong Wu (11019004@zju.edu.cn)



    Basic Information

    Gene Name: IL17A

    Description: interleukin 17A

    Entrez Gene ID: 3605

    SwissProt Acc Number: Q16552

    RefSeq: NM_002190

    It was suspected to be CHD related:

    ..we speculated that the SNP rs8193037 of IL17A gene is significantly associated with CAD risk in Chinese Han population and the rs8193037 G allele which is associated with increased expression of IL17A in AMI patients may be an independent predictive factor for CAD...

    From PMID: 21062626, in Journal Clin Chim Acta. , 2011


    References

    There were 1 potential papers with IL17A and CHD.

    PMIDTitleJournalsDetails
    21062626 Interleukin-17A gene variants and risk of coronary artery disease: a large angiography-based study.Clinica chimica acta; international journal of clinical chemistryMore Details

    NOTEs: These result is mostly from TEXT-MINING and there might have mismatches.



    PPI interactions

    There were totally 4 unique genes interacted with IL17A. Show PPI network

    Gene nameInteraction typereference PMIDCHD relation
    IL17A Reconstituted Complex9518462|9518462 CHD related
    TRAF3IP2 Affinity Capture-Western19825828 No
    TRAF6 Affinity Capture-Western19825828 No
    IL17RA in vitro;in vivo9367539 No


    Involved FDA drugs

    There was no drug associated with IL17A